Ingabe i-HPC ne-HPMC ziyefana?

I-HPC (Hydroxypropyl Cellulose) kanye ne-HPMC (Hydroxypropyl Methylcellulose) yizinto ezimbili eziphuma ku-cellulose ezincibilika emanzini ezivame ukusetshenziswa ezimbonini zemithi, zokudla nezamakhemikhali. Nakuba zifana kwezinye izici, izakhiwo zazo zamakhemikhali, izakhiwo kanye nezimo zokusebenzisa zihluke kakhulu.

1. Isakhiwo samakhemikhali
I-HPC: I-HPC iyingxenye ye-hydroxypropylated ephuma ku-cellulose. Yenziwa ngokusabela i-cellulose nge-propylene oxide futhi yethula amaqembu e-hydroxypropyl (-CH2CHOHCH3). Esakhiweni se-HPC, ingxenye yamaqembu e-hydroxyl yomgogodla we-cellulose ithathelwa indawo ngamaqembu e-hydroxypropyl, ayenze ibe yi-water-soluble kanye ne-thermoplastic.
I-HPMC: I-HPMC iyingxenye ye-hydroxypropylated kanye ne-methylated ephuma ku-cellulose. Ilungiswa ngokwethula amaqembu e-hydroxypropyl namaqembu e-methoxy (-OCH3) ku-cellulose. Isakhiwo samangqamuzana e-HPMC siyinkimbinkimbi kakhulu, ngakho kokubili ukwethulwa kwamaqembu e-hydroxypropyl kanye nokushintshwa kwe-methyl.

2. Izakhiwo zomzimba namakhemikhali
Ukunyibilika: Womabili angama-polymers ancibilika emanzini, kodwa ukuziphatha kwawo kokuncibilika kuhlukile. I-HPC inokunyibilika okuhle emanzini abandayo nezinye izincibilikisi eziphilayo (njenge-ethanol, i-propanol, njll.), kodwa ukunyibilika kwayo kungase kwehle emazingeni okushisa aphezulu (cishe ama-45°C noma ngaphezulu). I-HPMC ine-solubility enhle kakhulu emanzini abandayo, kodwa inezici ze-gelling emanzini aphezulu okushisa, okungukuthi, izinga lokushisa eliphakeme, i-HPMC encibilikisiwe emanzini izokwakha ijeli futhi ngeke isancibilika.
Ukuzinza kwe-thermal: I-HPC ine-thermoplasticity enhle, okusho ukuthi ingathambisa noma inyibilike emazingeni okushisa aphezulu, ngakho-ke ivame ukusetshenziswa ezintweni zokubumba ze-thermoplastic. I-HPMC inokumelana nokushisa okuphezulu, akulula ukuncibilika noma ukuthambisa, futhi ilungele ukusetshenziswa ngaphansi kwezimo zokushisa eziphezulu.
I-Viscosity: I-HPMC ivamise ukuba ne-viscosity ephezulu kune-HPC, ikakhulukazi embonini yezemithi, i-HPMC ivamise ukusetshenziswa ekwakhiweni okudinga ukubopha okuqinile noma ukunamathela, kuyilapho i-HPC isetshenziswa ezimeni lapho kudingeka i-viscosity emaphakathi noma ephansi.

3. Izinkambu zokufaka isicelo
Inkambu yezemithi:
I-HPC: I-HPC iyisakhi semithi, esetshenziswa kakhulu njenge-adhesive tablet, i-capsule shell film-forming agent, kanye nempahla ye-matrix yokukhishwa okulawulwayo kwezidakamizwa. Ngenxa ye-thermoplasticity yayo, ifaneleka namalungiselelo enqubo yokuncibilika okushisayo. I-HPC iphinde ibe nokuvumelana okuhle kwe-biocompatibility kanye nokuwohloka, futhi ifanele ukusetshenziswa njengohlelo lokulethwa kwezidakamizwa ngaphakathi emlonyeni.
I-HPMC: I-HPMC isetshenziswa kabanzi embonini yezemithi, futhi ivamise ukusetshenziswa njengempahla ye-matrix, impahla yokunameka, ukuqina kanye nokuqiniswa kwamaphilisi akhishwa isikhathi eside. Izici ze-gelling ze-HPMC ziyenza ibe into ekahle yokulawula ukukhishwa kwezidakamizwa, ikakhulukazi emgudwini wamathumbu, lapho ingakwazi ukulawula ngempumelelo izinga lokukhululwa kwezidakamizwa. Izakhiwo zayo ezinhle zokwenza ifilimu futhi zenza kube yisinqumo esiyinhloko sokumboza ithebhulethi kanye nokufakwa kwezinhlayiyana.

Inkambu yokudla:
I-HPC: Embonini yokudla, i-HPC ingasetshenziswa njenge-thickener, stabilizer kanye ne-emulsifier ukuthuthukisa ukuthungwa nokubukeka kokudla. Kwezinye izimo, ingasetshenziswa futhi njengefilimu edliwayo yezinto ezithile zokudla okudingeka zigcinwe zimanzi noma zodwa.
I-HPMC: I-HPMC ijwayele ukusetshenziswa njenge-thickener, emulsifier and stabilizer embonini yokudla, ikakhulukazi ezimpahleni ezibhakwayo njengesinkwa namakhekhe. I-HPMC isiza ukuthuthukisa ukwakheka nokuthungwa kwenhlama futhi yandise impilo yeshalofu yokudla. Ngaphezu kwalokho, i-HPMC iphinde isetshenziswe kabanzi ekudleni kwemifino njengendawo esekelwe esitshalweni esikhundleni se-collagen yezilwane.
Izimonyo nemikhiqizo yokunakekelwa komuntu siqu:

Kokubili i-HPC ne-HPMC zingasetshenziswa kuzimonyo njengamajini, ama-stabilizer kanye nabadali bamafilimu. Isibonelo, zingasetshenziswa ekunakekelweni kwesikhumba kanye nemikhiqizo yezinwele ukuthuthukisa ukuthinta nokuzinza komkhiqizo. I-HPMC ivamise ukuba ifaneleke kakhulu njenge-ejenti ye-colloid esobala, njenge-thickener emathonsini esweni, kuyilapho i-HPC ivamise ukusetshenziswa ezimeni lapho ukunamathela okuguquguqukayo kudinga ukwakhiwa.
Izinto zokwakha kanye nama-coatings:

I-HPMC: Ngenxa yokunamathela kwayo okuhle nokugcinwa kwamanzi, i-HPMC isetshenziswa kakhulu ezintweni zokwakha ezifana usimende, udaka, i-putty negypsum ukuze kuthuthukiswe ukunamathela kanye nokwenza ngcono ukusebenza komsebenzi wokwakha.
I-HPC: Ngokuphambene, i-HPC ayisetshenziswa kancane embonini yezokwakha futhi ivamise ukusetshenziswa njengesithasiselo noma okokunamathelisa ukumboza.

4. Ukuphepha kanye nokuvikelwa kwemvelo
Kokubili i-HPC ne-HPMC kuthathwa njengezinto eziphephile uma kuqhathaniswa futhi zisetshenziswa kakhulu ekudleni, emikhiqizweni yokwelapha kanye neyokunakekelwa komuntu siqu. Zombili zine-biocompatibility enhle kanye nokuwohloka, futhi ngeke kubangele imiphumela emibi enobuthi emzimbeni womuntu. Kodwa-ke, njengoba zingangeni emzimbeni womuntu futhi zisetshenziswa kuphela njengezinto ezisizayo, ngokuvamile azinayo imiphumela yesistimu emzimbeni womuntu. Ukwengeza, inqubo yokukhiqiza ye-HPC ne-HPMC ihambisana nemvelo, futhi amakhemikhali nezincibilikisi ezisetshenziswa ekukhiqizeni zingase zigaywe kabusha futhi zisetshenziswe kabusha.

Nakuba i-HPC ne-HPMC kokubili kuyizinto eziphuma ku-cellulose futhi zinezinhlelo zokusebenza ezihlukene kwezinye izinhlelo zokusebenza, zinomehluko omkhulu ekwakhekeni kwamakhemikhali, izakhiwo ezibonakalayo nezindawo zokusetshenziswa. I-HPC ifaneleka kakhulu izinhlelo zokusebenza ezidinga izinto ze-thermoplastic, njengokukhishwa okulawulwayo kwezidakamizwa kanye nezinqubo zokubumba ezincibilikayo ezishisayo, kuyilapho i-HPMC isetshenziswa kabanzi kwezemithi, ukudla, ukwakhiwa kanye neminye imikhakha ngenxa yokunamathela kwayo okuhle kakhulu, izakhiwo zefilimu nokugcinwa kwamanzi. . Ngakho-ke, yiziphi izinto ongazikhetha zincike ezidingweni ezithile zohlelo lokusebenza.