IHydroxypropyl Methylcellulose (HPMC) iyi-semi-synthetic, inert, i-high-viscosity polymer esetshenziswa kakhulu ekwakhiweni kwezidakamizwa. Izakhiwo zayo eziyingqayizivele zomzimba namakhemikhali ziyenza ibe wusizo olukhulu embonini yezemithi, ngokwakhiwa kwamafilimu, ukuqina, ukuzinza kanye nokuvumelana kwe-biocompatibility.
Izakhiwo eziyisisekelo ze-HPMC
I-HPMC yenziwe nge-methylating kanye ne-hydroxypropylating cellulose. Inoncibilika kahle emanzini kanye ne-thermoplasticity, futhi incibilika ngokushesha emanzini abandayo ukuze yakhe isixazululo se-colloidal esisobala. Ukunyibilika kwayo kanye ne-viscosity kungalawulwa ngokulungisa izinga lokushintsha kanye nezinga le-polymerization, okuvumela i-HPMC ukuthi ihlangabezane nezidingo zokwakheka kwezidakamizwa okuhlukile.
Izindawo zokufaka izicelo
1. Izidakamizwa ezikhishwa okulawulwayo
I-HPMC isetshenziswa kakhulu ekulungiseni izidakamizwa ezikhishwa okulawulwayo. Ngenxa yokuncibilika kwayo emanzini kanye nekhono lokwenza amajeli, i-HPMC ingalawula izinga lokukhululwa kwezidakamizwa. Izakhiwo zayo zokuvuvukala emgudwini wesisu zivumela umuthi ukuthi ukhululwe kancane kancane esikhathini esithile, ulawule ngempumelelo ukugcwala kwe-plasma yomuthi, unciphise imvamisa yemithi, futhi uthuthukise ukuthobela kwesiguli.
2. Ama-binders nama-disintegrants amaphilisi
Njengesihlanganisi nesihlukanisayo samaphilisi, i-HPMC ingathuthukisa amandla emishini amaphilisi ngenkathi iqinisekisa ukuthi amaphilisi ayahlakazeka futhi akhulule izithako ezisebenzayo ngesikhathi esifanele. Izici zayo zokunamathisela zisiza ukuhlanganisa izinhlayiya zomuthi ndawonye ukuze zakhe ithebhulethi eqinile, kuyilapho izakhiwo zayo zokuvuvukala zivumela amaphilisi ukuba ahlakazeke ngokushesha emanzini.
3. Ama-ejenti okufaka ifilimu
I-HPMC iyimpahla ebalulekile yokulungisa ifilimu yezidakamizwa. Ingasetshenziswa njengendwangu evikelayo yefilimu ukuvikela umuthi kumswakama, umoya-mpilo nokukhanya, ngaleyo ndlela kuthuthukiswe ukuzinza kwesidakamizwa. Ngaphezu kwalokho, i-HPMC ingasetshenziswa futhi njenge-enteric coating ukuvikela umuthi ekukhishweni esiswini futhi uqinisekise ukuthi umuthi ufakwa emathunjini.
4. Amalungiselelo e-Ophthalmic
Emalungiselelweni e-ophthalmic, i-HPMC ivame ukusetshenziselwa ukulungisa izinyembezi zokwenziwa kanye namaconsi iso. I-viscosity yayo ephezulu kanye ne-biocompatibility yenza ikwazi ukwenza ifilimu evikelayo ebusweni beso, igcobe iso, futhi ikhulule izimpawu zamehlo omile.
5. Amaphilisi
I-HPMC ingasetshenziswa ukulungisa amaphilisi aqinile namaphilisi athambile. Uma kuqhathaniswa namaphilisi e-gelatin endabuko, amaphilisi e-HPMC anokuqina okungcono kwamakhemikhali, akulula ukumunca umswakama, futhi anobungane kakhulu kubantu abadla imifino namakholwa enkolo.
Izici ezinomthelela
1. I-Viscosity
I-viscosity ye-HPMC ingenye yezinkomba ezibalulekile zokusebenza kwayo. I-HPMC ene-viscosity ephezulu ingasetshenziselwa izidakamizwa ezikhishwayo ezilawulwayo kanye namalungiselelo ahlanganiswe nefilimu, kuyilapho i-HPMC ene-viscosity ephansi ifaneleka kakhulu ukusetshenziswa njengesibophelelo kanye ne-disintegrant.
2. Izinga lokushintsha
Izinga lokushintsha (DS) kanye nokushintshwa kwe-molar (MS) ye-HPMC kuthinta ngokuqondile ukunyibilika kwayo kanye nekhono lokwakha ijeli. Ukulungiswa okufanele kwezinga lokushintsha kungathuthukisa umphumela wokusetshenziswa kwe-HPMC ekwenziweni kwezidakamizwa okuhlukile.
3. Izici zemvelo
Ukusebenza kwe-HPMC kuphinde kuthintwa yizici zemvelo ezifana nezinga lokushisa, inani le-pH namandla e-ionic. Lezi zici zidinga ukucatshangelwa lapho kulungiselelwa ukwakheka kwezidakamizwa ukuze kuqinisekiswe ukuthi i-HPMC isebenza kahle kakhulu.
IHydroxypropyl methylcellulose (HPMC), njengesakhi semithi esisebenza ngezindlela eziningi, esisebenza kahle kakhulu, sisetshenziswa kabanzi emikhakheni eminingi njengokukhululwa okulawulwa yizidakamizwa, amaphilisi, amalungiselelo ahlanganiswe nefilimu, amalungiselelo e-ophthalmic namaphilisi. Ngokulungisa i-viscosity yayo kanye nezinga lokushintsha, ingahlangabezana nezidingo zokwakheka kwezidakamizwa okuhlukile futhi ithuthukise kakhulu ukuzinza kanye nokuba khona kwezidakamizwa. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, amathuba okusebenzisa i-HPMC azoba banzi.
Isikhathi sokuthumela: Jul-11-2024