I-HPMC K4M (i-hydroxypropyl methylcellulose K4M) iyisisetshenziswa esivamile semithi esetshenziswa kabanzi embonini yezemithi, ikakhulukazi kumaphilisi akhishwa njalo, amalungiselelo okukhishwa okulawulwayo kanye namanye amalungiselelo aqinile omlomo.
Izakhiwo eziyisisekelo ze-HPMC K4M
I-HPMC K4M iyibanga elivamile le-Hydroxypropyl Methylcellulose (HPMC). I-HPMC iyi-semi-synthetic, i-high molecular weight multifunctional polymer material eyenziwe nge-cellulose eguqulwe ngamakhemikhali enezici ezinhle zomzimba namakhemikhali, njengokujiya okuhle kakhulu, i-gelling, ukwakheka kwefilimu kanye nezakhiwo zokunamathela.
I-HPMC K4M isetshenziswa kakhulu emkhakheni wezokwelapha ngenxa ye-viscosity yayo emaphakathi kanye nezakhiwo ezinhle kakhulu zokujiya nokwenza amafilimu. I-“K” ku-K4M imele i-viscosity cellulose ephezulu, futhi i-“4M” isho ukuthi i-viscosity yayo icishe ibe ngu-4000 centipoise (ekalwa ngesixazululo esinamanzi esingu-2%.
Izicelo eziyinhloko ze-HPMC K4M embonini yezemithi
1. Isicelo emalungiselelweni okukhululwa okuqhubekayo
Umsebenzi oyinhloko we-HPMC K4M kumalungiselelo okukhishwa okuqhubekayo ukusebenza njengento elawulwayo ekhishwayo ye-matrix. I-hydrophilicity yayo eyingqayizivele kanye nekhono lokwakha ijeli kuyenza ibe ngesinye sezisiza ezisetshenziswa kakhulu ezinhlelweni zokukhishwa kwezidakamizwa ezikhishwa isikhathi eside. I-HPMC K4M ingamunca ngokushesha amanzi futhi ivuvuke lapho ithintana namanzi, futhi yakhe ungqimba lwejeli ebusweni bethebhulethi, ibambezele izinga lokukhululwa komuthi, ngaleyo ndlela izuze umphumela wokukhululwa olawulwayo.
Le ndawo ifaneleka kakhulu amaphilisi akhishwa ngomlomo, njengezidakamizwa ezilwa nomfutho wegazi ophakeme, izidakamizwa ze-antidiabetic, nama-analgesics. Ngokusebenzisa i-HPMC K4M, umuthi ungakhululwa ngokuqhubekayo emzimbeni, ulondoloze ukugcwala kwezidakamizwa egazini njalo, ukwehlisa imvamisa yemithi, kanye nokwenza ngcono ukuthobela kwesiguli.
2. Amaphilisi nezinto zokugqoka
I-HPMC K4M, njengento yokumboza, ingakha ifilimu evikelayo ebusweni bokulungiselela. Ifilimu inezici ezinhle zokuvimbela, ezingavimbela ngokuphumelelayo izidakamizwa ukuthi zinganaki umswakama, i-oxidation noma ukukhanya, futhi andise ukuzinza nempilo yeshalofu yomuthi. Ngokungafani ne-gelatin yendabuko, i-HPMC isuselwa esitshalweni, ngakho ilungele abantu abadla imifino neziguli ezingazwani nezithako ezithathwe ezilwaneni.
I-HPMC K4M ingasetshenziswa futhi njengento yokulungiselela amagobolondo we-capsule, ishintsha amaphilisi e-gelatin, futhi isetshenziselwa ukuhlanganisa amaphilisi emifino nezidakamizwa ezibucayi, ngokuhambisana okuhle nokuphepha.
3. Njengomshini wokujiyisa kanye nesibopho
Embonini yezemithi, i-HPMC K4M isetshenziswa kakhulu ezinqubweni ze-granulation ezimanzi njenge-binder ukukhuthaza ukwakheka kwezinhlayiya. Izakhiwo zayo ezinhle kakhulu zokubopha zingaqinisekisa ukuthi izinhlayiya zinokuqina okuhle nokuhlakazeka, ukuqinisekisa ukuthi amaphilisi angakwazi ukuhlakazeka ngokushesha futhi akhulule umuthi lapho uthathwa. Ngaphezu kwalokho, i-HPMC K4M ingasetshenziswa futhi njenge-thickener ekulungiseleleni uketshezi, njengokumiswa kanye namalungiselelo e-ophthalmic, ukwandisa i-viscosity nokuzinza kwamalungiselelo.
4. I-Stabilizer ne-ejenti yokuzivikela
I-HPMC K4M ingasebenza njenge-stabilizer kanye ne-ejenti evikelayo kwamanye amalungiselelo, ikakhulukazi kumasistimu we-multiphase afana nama-emulsions kanye nokumiswa. Amakhono awo okuqina kanye nokwenza ijeli angavimbela umuthi ukuthi ungahlali noma uhlukanise phakathi nesikhathi sokugcina, uqinisekisa ukufana nokuzinza kokulungiswa. Ukwengeza, kwezinye izidakamizwa zebhayoloji noma izidakamizwa zamaprotheni, i-HPMC K4M ingasetshenziswa njenge-ejenti evikelayo ukuze kuvinjelwe iphrotheni ekujikeni noma ekwehliseni isithunzi ngesikhathi sokulungiswa noma ukugcinwa, iqinisekisa ukusebenza kwebhayoloji yomuthi.
5. Isithuthukisi sokumuncwa kwe-mucosal
Eminyakeni yakamuva, ucwaningo luye lwabonisa ukuthi i-HPMC K4M ingasetshenziswa njengesithuthukisi sokumuncwa kwe-mucosal ukusiza ukuthuthukisa i-bioavailability yeminye imithi okunzima ukuyimunca. Isibonelo, ngokuhlanganisa ne-HPMC K4M, amaprotheni athile kanye nemithi ye-peptide ingamuncwa kangcono kumasayithi we-mucosal njengendawo yomlomo, ikhala noma i-rectum, igweme umzila womjovo ovamile futhi inikeze indlela yokulawula elula nengahlaseli.
6. Umsebenzi wokulawula ukukhululwa kwezidakamizwa
I-HPMC K4M ayikwazi ukusetshenziswa nje kuphela njenge-matrix yokukhululwa elawulwayo eyodwa, kodwa futhi ingasetshenziswa ekuhlanganisweni nezinye izinto zokukhishwa ezilawulwayo (njenge-carbomer, i-ethyl cellulose, njll.) ukuze kulawulwe ngokuhlanganyela ukukhululwa kwezidakamizwa. Ngokushintsha ukugxilisa ingqondo, isisindo samangqamuzana noma isilinganiso se-HPMC K4M nezinye izinto ezisizayo, onjiniyela bezinqubo zemithi bangalungisa ngokunembile izinga lokukhishwa kwezidakamizwa ukuze kuhlangatshezwane nezidingo zokwelapha zemithi ehlukene.
Izinzuzo ze-HPMC K4M kwezemithi
Ukuphepha okuhle nokuvumelana kwe-biocompatibility: I-HPMC K4M yinto engenabuthi, engacasuli, futhi umthombo wayo i-cellulose yemvelo, elungele ukusetshenziswa isikhathi eside. Njengoba i-HPMC K4M ingancikile ekonakaleni kwe-enzyme yamathumbu, indlela yayo ye-metabolic emzimbeni ithambile kakhulu, inciphisa ingozi engaba khona yemiphumela emibi.
Kulula ukuyisebenzisa: I-HPMC K4M ingancibilika emanzini abandayo nashisayo, futhi isisombululo sinokuzinza okuhle futhi kulula ukuyisebenzisa. Amakhono ayo okwenza ifilimu kanye nokwenza ijeli ayinikeza inqubo enhle yokuvumelana nezimo enqubweni yokwenziwa kwemithi.
Uhlu olubanzi lwezinhlelo zokusebenza: I-HPMC K4M ayifaneleki kuphela amalungiselelo aqinile omlomo, kodwa futhi nezinhlobonhlobo zamanye amafomu omthamo, njengamalungiselelo e-topical, amalungiselelo e-ophthalmic, imijovo kanye namalungiselelo okuphefumula.
Njengomsizi wemithi osebenza ngezindlela eziningi, i-HPMC K4M ikwisikhundla esibalulekile embonini yezemithi ngezakhiwo zayo ezinhle kakhulu zomzimba namakhemikhali kanye nezinhlobonhlobo zezimo zokusetshenziswa. Inomthelela obalulekile ezicini eziningi ezifana namalungiselelo okukhishwa okuqhubekayo, ama-thickeners, izinto zokumboza, iziqinisi, njll., ikakhulukazi ekulungiseni amaphilisi omlomo akhishwa okuqhubekayo, inezinzuzo ezingenakuphikwa. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, amathuba okufaka isicelo e-HPMC K4M azoba banzi, futhi isikhundla sayo emalungiselelweni emithi emisha sizoqhubeka nokuba ngcono.
Isikhathi sokuthumela: Sep-29-2024