Ukusetshenziswa kwe-ethyl cellulose kumalungiselelo emithi

Ethylcellose (EC)iyingxenye ye-polymer ye-semi-zokwenziwa etholwe ngokutholwa kwe-tellulose yezitshalo zemvelo. Isakhiwo esijwayelekile samangqamuzana sakhiwa ama-glucose amayunithi axhunywe ngamabhondi angu-β-1,4-glycosidic. Ngenxa yokuthambekela kwayo okuhle kakhulu, okungeyona ubuthi, ukuziphendulela okuhle kanye nemithombo eminingi, i-ethyl cellulose isetshenziswa kabanzi kumalungiselelo emithi, ikakhulukazi embonini yezemithi.

1. Izakhiwo eziyisisekelo ze-ethyl cellulose

I-Ethyl Cellulose inokuthambekela okuphezulu futhi ikhona emzimbeni womuntu isikhathi eside ngaphandle kokukhiqiza ukusabela okunobuthi. Isakhiwo saso samakhemikhali sikunikeza i-hydrophobicity enhle, ukuqina, i-acid kanye nokuphikiswa kwe-alkali kanye nezakhiwo ezithile zokukhishwa ezilawulwayo. Ngaphezu kwalokho, i-ethyl cellulose iyi-insoluble emanzini, kepha incibilika ezinhlafunweni ze-organic njenge-ethanol, i-chloroform, i-acetone, njll. Lezi zindawo ziwunikeza amathemba ahlukahlukene wohlelo lokusebenza emakheni.

2. Ukusetshenziswa kwe-ethyl cellulose kumalungiselelo emithi

Inkambu yesicelo ye-ethyl cellulose ibanzi kakhulu, imboza amalungiselelo omlomo, imijovo, amalungiselelo angaphandle nezinye izici eziningi. Lokhu okulandelayo kungukusetshenziswa okuningana okuphambili kwe-ethyl cellulose kumalungiselelo emithi.

2.1 Amalungiselelo wokukhishwa alawulwa izidakamizwa zomlomo

Ukusetshenziswa okuvame kakhulu kwe-ethyl cellulose kunjenge-ejenti yokukhishwa okulawulwayo, ikakhulukazi kumalungiselelo wokukhishwa alawulwayo wezidakamizwa zomlomo. Imvelo ye-hydrophobic nokulawulwa kwe-ethyl cellulose kwenza kube yinto ekahle izidakamizwa ezilondoloziwe. Emalungitheni okukhishwa kwezidakamizwa, i-ethyl cellulose ingabambezela isilinganiso sokukhishwa kwesidakamizwa ngokwakhiwa i-coating yefilimu, ngaleyo ndlela izuze inhloso yokwandisa umphumela wezidakamizwa. Ngokushintsha isisindo se-molecular ye-ethyl cellulose, ukushuba kwesendlalelo sombango nohlobo lwe-solvent ekhethiwe, isilinganiso sokukhululwa kanye nemodi yokukhishwa kwesidakamizwa ingalawulwa.

I-Ethyl cellulose ivame ukusetshenziselwa ukulungiselela amaphilisi we-Orgal Odiowid Releached Refered Releached Umuthi ugoqwe kwifilimu ye-ethyl cellulose. Inqubo yokukhishwa kwezidakamizwa ingalawulwa ngokuvuvukala kanye ne-solubility yefilimu nokungena kwe-solvent. Ngokwezakhi ezahlukahlukene kanye nemibandela yenqubo, i-ethyl cellulose ingalawula ngempumelelo isikhathi sokukhishwa kwezidakamizwa, yehlisa inani lezikhathi zokwenza izidakamizwa, futhi ithuthukise ukulandelwa kweziguli.

2.2 I-Drug Film coating

Kumalungiselelo wezidakamizwa, i-ethyl cellulose ivame ukusetshenziselwa ukuhlanganiswa kwamafilimu, ikakhulukazi kumalungiselelo aqinile omlomo afana namathebulethi, ama-granules kanye nama-caplule. Njengezinto zokuhlangana zefilimu, i-ethyl cellulose inezakhiwo ezinhle ezenziwe ngamafilimu, ukushelela kanye namandla emishini, anganikeza ukuvikela izinhlayiya zezidakamizwa futhi kuvikele isidakamizwa ekunciphiseni imvelo ye-gastric acid. Ngasikhathi sinye, ifilimu le-ethylpulevose lingalawula isilinganiso sokukhishwa kwesidakamizwa, ikakhulukazi ngokulungisa ubukhulu befilimu futhi basebenzise izixazululo ezahlukahlukene, kungatholakala amajika ahlukile.

Njengezinto ezihlanganayo, i-ethyl cellulose nayo ingathuthukisa ukunambitheka kwesidakamizwa, igweme ukuncipha noma ukungaphatheki kahle, futhi yandise ukwamukelwa kweziguli.

2.3 emulsion kanye namalungiselelo we-micellar

Ngenxa ye-solubility yayo kanye nomsebenzi ongaphezulu, i-ethyl cellulose nayo isetshenziswa kabanzi kumalungiselelo we-emulsion kanye namalungiselelo we-micellar. Lapho kulungiswa ama-emulsions, i-ethyl cellulose, njenge-emulsifier ne-stabilizer, ingathuthukisa ngempumelelo i-solubility yomuthi futhi yandise ukusebenza kahle kwesidakamizwa. Ikakhulu ezinye izidakamizwa ezinamafutha ancibilikisiwe, i-ethyl cellulose ingasiza ekusabalaliseni isidakamizwa esigabeni esingamanzi, inciphise imvula yesidakamizwa emanzini, futhi ithuthukise ukungatholakali kwe-bioavailability yomuthi.

Emalungiseleleni ama-micellar, i-ethyl cellulose, njenge-stabilizer, ingakha ukwakheka kwesidakamizwa esizinzile, ngaleyo ndlela ithuthukise i-solubity kanye nokuvulula izidakamizwa emzimbeni, ikakhulukazi kwezinye izidakamizwa ezingenamkhawulo ezingenampilo.

2.4 amalungiselelo ezidakamizwa aphezulu

I-KimaCell®elsose isetshenziswa kabanzi kumalungiselelo wezidakamizwa aphezulu, ikakhulukazi lapho kulungiswa ama-ointrements, okhilimu, amagugu namanye amalungiselelo. Njengomkhulu, ifilimu yangaphambili ne-Stabilizer, ethyl cellulose ingathuthukisa ukusakazeka, ukunamathela kanye nokufana kwezidakamizwa eziphezulu. Kumalungiselelo aphezulu afana namafutha nokhilimu, i-ethyl cellulose ingathuthukisa ukubonwa kanye nokuqina kwamalungiselelo, iqinisekisa ukusatshalaliswa komfaniswano nokukhishwa okuqhubekayo kwesidakamizwa ngesikhathi sokusetshenziswa.

2.5 Uhlelo Lomthwali Wezidakamizwa

I-Ethyl Cellulose ingasetshenziswa futhi njengesithwali sezidakamizwa, ikakhulukazi lapho kulungiswa ama-nanocriers kanye ne-microcalrariers. I-Ethyl cellulose ingakha izakhiwo ezine-molecule yezidakamizwa ukuhlinzeka ngokulawulwa kwezidakamizwa okungcono. Ezinhlelweni ze-nanoCarrier, izakhiwo ezingaphezulu ze-ethyl cellulose zingathuthukiswa ngokuguqulwa kwamakhemikhali noma ukwelashwa ngokomzimba ukuze kuthuthukiswe ukusebenza kwezidakamizwa nokukhipha ukusebenza kwezinga lokulawula isilinganiso.

3. Izinzuzo nezinselelo ze-Ethyl Cellulose

Njenge-excipont yokulungiselela izidakamizwa, iKimacell®elivullose inezinzuzo eziningi. Inobuhlakani obuhle kanye ne-biodeGreatibility, enganciphisa imiphumela emibi emzimbeni womuntu; kungalawula ngempumelelo ukukhishwa kwezidakamizwa futhi kuthuthukise umphumela wokwelapha wezidakamizwa; Ngaphezu kwalokho, ubuchwepheshe bokucubungula kwe-ethyl cellulose buvuthiwe, busetshenziswa kabanzi, budla kancane, futhi bulungele ukukhiqizwa okukhulu. Kodwa-ke, i-ethyl cellulose ibuye ibhekene nezinselelo ezithile. Isibonelo, ngaphansi kwamanani athile aphezulu e-PH noma izimo zokushisa eziphakeme, ukuqina kwe-ethyl cellul kungancipha, kungathinta umphumela wayo wohlelo lokusebenza ezindaweni ezithile.

I-ethyl celluloseinezinhlobonhlobo zamathemba wohlelo lokusebenza kumalungiselelo emithi, ikakhulukazi emikhakheni yamalungiselelo wokukhishwa alawulwa, ukumboza amafilimu, ama-emulsions, kanye namalungiselelo aphezulu. Izakhiwo zalo ezinhle kakhulu zomzimba kanye namakhemikhali zikwenza kube yisasasa elibaluleke kakhulu kumalungiselelo emithi. Kodwa-ke, kuzinhlelo zokusebenza ezisebenzayo, kusadingekile ukwenza kahle futhi kuthuthukise izinhlobo ezithile zezidakamizwa namafomu okulungiselela ukunqoba izinselelo zayo ngokuqina, ukulawulwa kokulawulwa, njll., Futhi kuphinde kuthuthukise umphumela wokwelapha wezidakamizwa nokulandela iziguli.