Focus on Cellulose ethers

Ukusetshenziswa kwe-axiliary material hydroxypropyl cellulose ekulungiseleleni okuqinile

I-Hydroxypropyl cellulose, i-excipient yezemithi, ihlukaniswe yaba yi-hydroxypropyl cellulose (L-HPC) efakwe endaweni ephezulu esikhundleni se-hydroxypropyl cellulose (H-HPC) ngokuya ngokuqukethwe kwe-hydroxypropoxy yayo. I-L-HPC ikhukhumala ibe yisisombululo se-colloidal emanzini, inezici zokunamathela, ukwakheka kwefilimu, i-emulsification, njll., futhi isetshenziswa ngokuyinhloko njenge-ejenti ehlakazayo kanye ne-binder; kuyilapho i-H-HPC incibilika emanzini nasezincibilikisini ezihlukahlukene eziphilayo ekamelweni lokushisa, futhi ine-thermoplasticity enhle. , ukubumbana kanye nezakhiwo zefilimu, ifilimu eyenziwe iqinile, icwebezelayo, futhi inwebeka ngokugcwele, futhi isetshenziswa ngokuyinhloko njengento yokwenza ifilimu kanye nezinto zokumboza. Ukusetshenziswa okuqondile kwe-hydroxypropyl cellulose emalungiselelweni aqinile manje sekwethulwa.

1. Njenge-disintegrant yamalungiselelo aqinile njengamaphilisi

Indawo ephansi efakwe esikhundlenii-hydroxypropyl celluloseizinhlayiya zekristalu azilingani, zinesakhiwo esifana nedwala esinesimo sezulu esisobala. Lesi sakhiwo esingaphezulu esimangelengele asigcini nje ngokuyenza ibe nendawo enkulu, kodwa futhi lapho sicindezelwa ithebhulethi kanye nezidakamizwa nezinye izinto ezisizayo, kwakheka ama-pores amaningi nama-capillaries emgodleni wethebhulethi, ukuze umgogodla wethebhulethi ukwazi ukwandisa umswakama. izinga lokumuncwa kanye nokumuncwa Amanzi kwandisa ukuvuvukala. Ukusebenzisa i-L-HPC njenge-excipient kungenza ithebhulethi ihlakazeke ngokushesha ibe impushana efanayo, futhi ithuthukise kakhulu ukuhlakazeka, ukuhlakazeka kanye ne-bioavailability yethebhulethi. Isibonelo, ukusetshenziswa kwe-L-HPC kungasheshisa ukuhlakazeka kwamaphilisi e-paracetamol, amaphilisi e-aspirin, namaphilisi e-chlorpheniramine, futhi kuthuthukise izinga lokuqedwa. Ukuhlakazeka nokuhlakazwa kwezidakamizwa ezingancibiliki kahle njengamaphilisi e-ofloxacin ane-L-HPC njengama-disintegrants bekungcono kunalawo ane-PVPP exhumene, i-CMC-Na ne-CMS-Na njengezinqamuli. Ukusebenzisa i-L-HPC njenge-disintegrant yangaphakathi yama-granules kuma-capsules kunenzuzo ekuhlakazeni kwama-granules, kwandisa indawo yokuxhumana phakathi kwesidakamizwa kanye nendawo yokuchithwa, ikhuthaza ukuqedwa komuthi, futhi ithuthukise i-bioavailability. Amalungiselelo aqinile akhishwa ngokushesha amelelwa amalungiselelo aqinile ahlakazeka ngokushesha kanye namalungiselelo aqinile ahlakazeka ngokushesha anemiphumela ehlakazeka ngokushesha, ehlakazeka ngokushesha, esebenza ngokushesha, i-bioavailability ephezulu, ukucasuka kwezidakamizwa okuncishisiwe kumminzo kanye nomgudu wokugaya ukudla, futhi kulula ukuyithatha. futhi ube nokuhambisana okuhle. kanye nezinye izinzuzo, obambe isikhundla esibalulekile emkhakheni ekhemisi. I-L-HPC isibe esinye sezisetshenziswa ezibaluleke kakhulu zokulungiswa okuqinile kokukhishwa ngokushesha ngenxa ye-hydrophilicity yayo eqinile, i-hygroscopicity, ukunwebeka, isikhathi esifushane se-hysteresis sokumuncwa kwamanzi, isivinini sokumuncwa okusheshayo, kanye nokugcwala kwamanzi okusheshayo. Kuyi-disintegrant efanelekile yamaphilisi ahlakazeka ngomlomo. Amaphilisi e-Paracetamol ahlakazeka ngomlomo alungiswa nge-L-HPC njenge-disintegrant, futhi amaphilisi ahlakazeka ngokushesha phakathi kweminyaka engama-20. I-L-HPC isetshenziswa njenge-disintegrant kumaphilisi, futhi umthamo wayo ojwayelekile ngu-2% kuya ku-10%, ikakhulukazi u-5%.

2. Njengesibophezelo samalungiselelo njengamaphilisi nama-granules

Isakhiwo esimahhadlahhadla se-L-HPC siphinde siyenze ibe nomthelela omkhulu we-mosaic enezidakamizwa nezinhlayiya, okwandisa izinga lokuhlangana, futhi inokusebenza okuhle kokubumba kokucindezelwa. Ngemva kokucindezelwa kumathebulethi, kukhombisa ubulukhuni obengeziwe kanye nokucwebezela, ngaleyo ndlela kuthuthukiswe ikhwalithi yokubukeka kwethebhulethi. Ikakhulukazi kumathebulethi okungelula ukuwenza, axegekile noma kulula ukuwadalula, ukwengeza i-L-HPC kungathuthukisa umphumela. Ithebhulethi ye-ciprofloxacin hydrochloride inokucindezelwa okubi, ukuhlukaniswa kalula nokunamathela, futhi kulula ukuyakheka ngemva kokwengeza i-L-HPC, enobulukhuni obufanele, ukubukeka okuhle, futhi izinga lokuchithwa lihlangabezana nezidingo ezijwayelekile zekhwalithi. Ngemuva kokwengeza i-L-HPC kuthebhulethi ehlakazekayo, ukubukeka kwayo, ukuqina, ukufana kokusabalalisa nezinye izici kuthuthukiswa kakhulu futhi kuthuthukiswe. Ngemuva kokuthi isitashi esibhalweni sokuqala sithathelwe indawo yi-L-HPC, ubulukhuni bethebhulethi ye-azithromycin ehlakazekayo banda, ukuqina kwaba ngcono, futhi izinkinga zamakhona alahlekile nemiphetho ebolile yethebhulethi yokuqala zaxazululwa. I-L-HPC isetshenziswa njengesibophezelo samaphilisi, kanti isilinganiso esijwayelekile singama-5% kuya ku-20%; kuyilapho i-H-HPC isetshenziswa njengesibophezelo samaphilisi, ama-granules, njll., futhi umthamo ojwayelekile ungu-1% kuya ku-5% wokulungiswa.

3. Ukufaka isicelo embotsheni yefilimu kanye namalungiselelo okukhululwa aqhubekayo futhi alawulwayo

Njengamanje, izinto ezincibilikayo emanzini ezivame ukusetshenziswa ekuhlanganiseni ifilimu zihlanganisa i-hydroxypropylmethylcellulose (HPMC), i-hydroxypropylcellulose, i-polyethylene glycol (PEG) njalonjalo. I-Hydroxypropyl cellulose ivamise ukusetshenziswa njenge-ejenti yokwakha ifilimu ezintweni zokuhlanganisa ifilimu ngenxa yefilimu yayo eqinile, enwebekayo futhi ecwebezelayo. Uma i-hydroxypropyl cellulose ixubene namanye ama-agent enamathela okumelana nokushisa, ukusebenza kokumbozwa kwayo kungathuthukiswa nakakhulu.

Kusetshenziswa izinto ezisizayo ezifanele kanye namasu okwenza umuthi ube amaphilisi e-matrix, amaphilisi antantayo esiswini, amaphilisi anezingqimba eziningi, amaphilisi ahlanganiswe, amaphilisi epompo ye-osmotic namanye amaphilisi akhulula kancane nalawulwayo, ukubaluleka kulele kulokhu: ukwandisa izinga lokumuncwa kwezidakamizwa kanye nokuzinza umuthi egazini. Ukugxilisa ingqondo, ukunciphisa ukusabela okubi, ukunciphisa inani lemithi, futhi ulwele ukukhulisa umphumela wokwelapha ngomthamo omncane kakhulu, futhi unciphise ukusabela okubi. I-Hydroxypropyl cellulose ingenye yezinto ezisiza kakhulu zamalungiselelo anjalo. Ukuqedwa nokukhululwa kwamaphilisi e-diclofenac sodium kulawulwa ngokusebenzisa i-hydroxypropyl cellulose kanye ne-ethyl cellulose njengento ehlangene ne-skeleton. Ngemuva kokuphathwa ngomlomo kanye nokuxhumana nejusi yesisu, ingaphezulu lamaphilisi e-diclofenac sodium-release-release azofakwa emanzini abe yijeli. Ngokuhlakazwa kwejeli kanye nokusabalalisa ama-molecule ezidakamizwa esikhaleni sejeli, inhloso yokukhululwa kancane kwama-molecule ezidakamizwa iyafinyelelwa. I-Hydroxypropyl cellulose isetshenziswa njenge-matrix yokukhishwa okulawulwayo yethebhulethi, lapho okuqukethwe kwe-blocker ethyl cellulose kungashintshi, okuqukethwe kwayo kuthebhulethi kunquma izinga lokukhululwa komuthi, kanye nomuthi ovela kuthebhulethi enokuqukethwe okuphezulu. ye-hydroxypropyl cellulose Ukukhishwa kuhamba kancane. Ama-pellets ahlanganisiwe alungiswa ngokusebenzisa i-L-HPC kanye nengxenye ethile ye-HPMC njengesixazululo sokumboza njengongqimba oluvuvukalayo, futhi njengesendlalelo esilawulwayo sokukhishwa kokugqoka nge-ethyl cellulose dispersion aqueous. Lapho ungqimba oluvuvukalayo kadokotela kanye nomthamo kulungiswa, ngokulawula ukushuba kongqimba olulawulwayo lokukhululwa, ama-pellets amboziwe angakhululwa ngezikhathi ezilindelekile ezihlukene. Izinhlobo ezimbalwa zama-pellets amboziwe anesisindo esihlukile sesendlalelo sokukhishwa okulawulwayo ziyaxutshwa ukwenza amaphilisi e-Shuxiong akhishwa okuqhubekayo. Endaweni yokuncibilika, ama-pellets ahlukahlukene amboziwe angakhipha izidakamizwa ngokulandelana ngezikhathi ezahlukene, ukuze izingxenye ezinezakhiwo ezahlukene zomzimba namakhemikhali zifinyelelwe ngesikhathi esifanayo nokukhululwa okuqhubekayo.


Isikhathi sokuthumela: Dec-28-2022
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