Ngokuthuthuka okuqhubekayo kwemboni yezemithi kanye nokuthuthuka kobuchwepheshe bezemithi, isidingo samafomu omthamo wemithi nawo siyakhula. Phakathi kwamafomu amaningi omthamo, amaphilisi asephenduke ifomu lemithamo elisetshenziswa kakhulu embonini yezemithi ngenxa ye-bioavailability yawo enhle kanye nokuthobela isiguli. Eminyakeni yamuva, amaphilisi angenalutho e-HPMC (hypromellose) kancane kancane athatha isikhundla esibalulekile ekukhiqizeni imithi ngenxa yezinzuzo zawo ezibalulekile.
(1) Uhlolojikelele oluyisisekelo lwamaphilisi angenalutho e-HPMC
I-HPMC, noma i-hypromellose, iyinhlanganisela ye-polymer etholakala ngokwemvelo ngokuvamile etholakala ku-pulp yokhuni noma ifayibha kakotini ngochungechunge lwemithi yokwelapha. Isakhiwo esiyingqayizivele se-HPMC siyinikeza izakhiwo ezinhle kakhulu zomzimba namakhemikhali, njengokubonakala okuphezulu, amandla amahle omshini, ukunyibilika okuzinzile, kanye ne-viscosity efanelekile. Lezi zakhiwo zenza i-HPMC isetshenziswe kabanzi emikhakheni eminingi, ikakhulukazi emkhakheni wezokwelapha.
(2) Izinzuzo eziyinhloko ze-HPMC amaphilisi angenalutho
1. Imvelaphi yezitshalo kanye nokuhambisana kwemifino
Impahla eluhlaza yama-capsules angenalutho e-HPMC itholakala ikakhulukazi ku-fiber yezitshalo, okwenza kube ukukhetha okuhle kwabadla imifino. Ngokungafani namaphilisi e-gelatin endabuko, amaphilisi angenalutho e-HPMC awaqukethe izithako zezilwane, ngakho isidingo sawo semakethe sikhula ngokushesha ezindaweni ezinemikhawulo eqinile yemifino, yenkolo noma yamasiko. Le nzuzo ayihambisani kuphela nokukhathazeka kwabathengi banamuhla mayelana nezempilo kanye nokuvikelwa kwemvelo, kodwa futhi inikeza ukusekelwa okuqinile kwezinkampani ezenza imithi ukuze zandise imakethe yomhlaba wonke.
2. Ukuzinza okuhle kwamakhemikhali
Amaphilisi angenalutho e-HPMC azinzile kakhulu kumakhemikhali futhi awathinteki kalula yizici zemvelo ezifana nezinga lokushisa kanye nomswakama. Lesi sakhiwo sinikeza izinzuzo ezibalulekile ngesikhathi sokugcina nokuhamba. Ngokuphambene nalokho, amaphilisi e-gelatin athambekele ekuphenduleni kokuxhumanisa ezindaweni ezishisayo nezinomswakama ophezulu, okuthinta ukunyibilika kanye nokuba khona kwezidakamizwa. Amaphilisi angenalutho e-HPMC angakwazi ukugcina kangcono izithako ezisebenzayo zomuthi futhi andise impilo yeshalofu yomuthi.
3. I-solubility enhle kakhulu kanye ne-bioavailability
Amaphilisi angenalutho e-HPMC anesivinini sokuqedwa okusheshayo kanye nezinga eliphezulu lokumunca emzimbeni womuntu, okuvumela ukuthi umuthi ukhululwe ngokushesha emzimbeni futhi uzuze umphumela ofanele wokwelapha. Ukunyibilika kwayo akuthintwa kancane inani le-pH yendawo ezungezile futhi kungagcina izinga lokuncibilika elizinzile ngaphakathi kwebanga le-pH elibanzi. Ngaphezu kwalokho, amaphilisi angenalutho e-HPMC anokuqina okuqinile emgudwini wesisu, okwenza kube lula ukumuncwa kwezidakamizwa endaweni futhi kuthuthukise ukutholakala kwezidakamizwa.
4. Zijwayelanise nezinhlobonhlobo zezicelo ngamafomu emithamo ahlukene
Ama-capsules angenalutho e-HPMC anamandla amahle kakhulu okusebenza futhi angakwazi ukuzivumelanisa nezidingo zokugcwalisa ngesivinini esikhulu zemigqa yokukhiqiza ezenzakalelayo futhi anciphise ukulahlekelwa ngesikhathi senqubo yokukhiqiza. Ngaphezu kwalokho, amaphilisi angenalutho e-HPMC anokumelana nokucindezela okuqinile kanye nezakhiwo ezinhle zokuvala, ezingavimbela ngempumelelo izidakamizwa ekutholeni umswakama noma oxidized. Ngenxa yokungathathi hlangothi kwama-capsules angenalutho e-HPMC, ahambisana nezinhlobonhlobo zezithako zemithi futhi afanele izinhlobo ezahlukene zemithamo yemithi, njengamalungiselelo aqinile, amalungiselelo oketshezi, amalungiselelo aqinile, njll.
5. Yehlisa ingozi yokungezwani nomzimba
Enye inzuzo ebalulekile ye-HPMC amaphilisi angenalutho yi-hypoallergenicity yawo. Uma kuqhathaniswa namaphilisi e-gelatin endabuko, amaphilisi e-HPMC awaqukethe izithako zamaprotheni, ngakho-ke ingozi yokungezwani komzimba iyancipha kakhulu. Lokhu kubaluleke kakhulu ezigulini ezingezwani namaprotheni ezilwane, okwenza umuthi uphephe ukusetshenziswa kula maqembu eziguli.
(3) Izinselelo namathemba e-HPMC amaphilisi angenalutho ekukhiqizeni imithi
Nakuba amaphilisi angenalutho e-HPMC anezinzuzo ezibalulekile ezicini eziningi, ukusetshenziswa kwawo okusabalele ekukhiqizeni imithi kusabhekene nezinselele ezithile. Isibonelo, izindleko eziphezulu zamaphilisi angenalutho e-HPMC uma kuqhathaniswa namaphilisi e-gelatin endabuko angase abe isithiyo kwezinye izimakethe ezizwelayo amanani. Ukwengeza, umswakamo wamaphilisi angenalutho e-HPMC uphansi, futhi ukusetshenziswa kumafomu athile omthamo owomile kungase kudinge ukwakhiwa okwengeziwe.
Ngokuthuthuka kobuchwepheshe kanye nokwandiswa kwesikali sokukhiqiza, izindleko zokukhiqiza amaphilisi angenalutho e-HPMC kulindeleke ukuthi zehliswe nakakhulu. Ngasikhathi sinye, izimfuno zabathengi ezikhulayo zempilo kanye nokuvikelwa kwemvelo zizokhuthaza ukusetshenziswa kwamaphilisi angenalutho e-HPMC emakethe yomhlaba. Ngaphezu kwalokho, ukwenziwa ngcono kwefomula yamaphilisi angenalutho e-HPMC kanye nokuthuthukiswa kwezinto ezintsha kuzothuthukisa ukuncintisana kwayo embonini yezemithi.
Amaphilisi angenalutho e-HPMC abonise amathuba abanzi ekukhiqizweni kwemithi ngenxa yemvelaphi yezitshalo, ukuqina kwamakhemikhali, ukuncibilika okuhle kanye nokuba khona kwe-bioavailability, ukuguquguquka kwezicelo okubanzi kanye nokungezwani komzimba okuncane. Naphezu kokubhekana nezinselelo ezithile, ngokuthuthuka kobuchwepheshe kanye nokukhula kwesidingo semakethe, amaphilisi angenalutho e-HPMC kulindeleke ukuthi athathe isikhundla esibaluleke kakhulu embonini yezemithi yesikhathi esizayo, ehlinzeka izinkampani zemithi ngezinketho namathuba amaningi.
Isikhathi sokuthumela: Sep-03-2024