Hydroxypropylmethylcellulose (HPMC) jẹ polymer multifunctional ti o wa lati inu cellulose adayeba. O jẹ lilo ni ọpọlọpọ awọn ile-iṣẹ, pẹlu awọn oogun, ounjẹ, ikole ati awọn ohun ikunra. Isejade ti HPMC ni pẹlu ọpọlọpọ awọn ohun elo aise ati ilana igbesẹ pupọ.
Cellulose:
Orisun: Ohun elo aise akọkọ ti HPMC jẹ cellulose, carbohydrate eka ti a rii ninu awọn odi sẹẹli ọgbin. Orisun cellulose ti o wọpọ julọ fun iṣelọpọ HPMC jẹ pulp igi, ṣugbọn awọn orisun miiran gẹgẹbi awọn linters owu tun le ṣee lo.
Igbaradi: Cellulose ni a maa n ṣe itọju lati yọ awọn idoti kuro lẹhinna ni ilọsiwaju sinu fọọmu ti o dara fun iyipada siwaju sii.
Ipilẹ:
Iru: Sodium hydroxide (NaOH) tabi potasiomu hydroxide (KOH) ni a maa n lo gẹgẹbi ipilẹ lakoko awọn ipele ibẹrẹ ti iṣelọpọ HPMC.
Iṣẹ: A lo Alkali lati ṣe itọju cellulose, nfa ki o wú ati ki o run eto rẹ. Ilana yii, ti a npe ni alkalization, ngbaradi cellulose fun awọn aati siwaju sii.
Aṣoju etherifying Alkali:
Aṣoju Hydroxypropylating: Propylene oxide ni igbagbogbo lo lati ṣafihan awọn ẹgbẹ hydroxypropyl sinu ẹhin cellulose. Igbese yii n funni ni solubility ati awọn ohun-ini miiran ti o fẹ si cellulose.
Awọn aṣoju methylating: Methyl kiloraidi tabi sulfate dimethyl ni a maa n lo lati ṣafihan awọn ẹgbẹ methyl sori ilana sẹẹli, nitorinaa imudara awọn ohun-ini gbogbogbo rẹ.
Aṣoju methylation:
Methanol: Methanol ti wa ni lilo nigbagbogbo bi epo ati reactant ni awọn ilana methylation. O ṣe iranlọwọ lati ṣafihan awọn ẹgbẹ methyl sinu awọn ẹwọn cellulose.
Awọn aṣoju hydroxypropylating:
Propylene oxide: O jẹ ohun elo aise bọtini fun iṣafihan awọn ẹgbẹ hydroxypropyl sinu cellulose. Idahun laarin propylene oxide ati cellulose waye labẹ awọn ipo iṣakoso.
ayase:
Oluṣeto Acid: Oluṣeto acid kan, gẹgẹbi sulfuric acid, ni a lo lati ṣe igbelaruge iṣesi etherification. Wọn ṣe iranlọwọ iṣakoso awọn oṣuwọn ifaseyin ati awọn ohun-ini ọja.
Yiyọ:
Omi: Omi ni igbagbogbo lo bi epo ni awọn ipele oriṣiriṣi ti ilana iṣelọpọ. O ṣe pataki fun dissolving reactants ati igbega awọn lenu laarin cellulose ati etherifying òjíṣẹ.
Adaṣeduro:
Sodium hydroxide (NaOH) tabi potasiomu hydroxide (KOH): ti a lo lati yomi awọn ayase acid ati ṣatunṣe pH lakoko iṣelọpọ.
ìwẹnumọ́:
Awọn iranlọwọ àlẹmọ: Orisirisi awọn iranlọwọ àlẹmọ ni a le lo lati yọ awọn aimọ ati awọn ọja-ọja ti aifẹ kuro ninu idapọ iṣesi.
Awọn iwẹwẹ: Fifọ pẹlu omi tabi awọn olomi miiran ṣe iranlọwọ lati yọ awọn kemikali to ku ati awọn aimọ kuro ninu ọja ikẹhin.
Aṣepe:
Afẹfẹ tabi gbigbe adiro: Lẹhin ìwẹnumọ, ọja naa le jẹ afẹfẹ tabi adiro ti o gbẹ lati yọ iyọkuro ti o ku ati ọrinrin kuro.
Aṣoju iṣakoso didara:
Awọn atunto Analytical: Orisirisi awọn reagents ni a lo fun awọn idi iṣakoso didara lati rii daju pe awọn ọja HPMC pade iṣẹ ṣiṣe ati awọn pato.
Isejade ti hydroxypropyl methylcellulose jẹ pẹlu iyipada cellulose nipasẹ lẹsẹsẹ awọn aati kemikali. Awọn ohun elo aise pẹlu cellulose, alkali, oluranlowo etherifying, ayase, epo, oluranlowo didoju, aṣoju mimọ ati desiccant, eyiti o ṣe ipa pataki ninu ilana iṣelọpọ. Awọn ipo kan pato ati awọn reagents ti a lo le yatọ si da lori awọn ohun-ini ti o fẹ ati ohun elo ti ọja hydroxypropyl methylcellulose ikẹhin.
Akoko ifiweranṣẹ: Oṣu kejila-21-2023