I-Hydroxypropyl methylcellulose (i-HPMC) i-polymer compound eqhelekileyo kunye noluhlu olubanzi lwezicelo zoshishino, ngokukodwa kwiinkalo zamachiza, ukutya, izinto zokwakha kunye nezithambiso. Ukunyibilika kwayo emanzini kunye neempawu ezityebisayo zenza ukuba ibe yinto efanelekileyo yokutyeba, ukuzinzisa kunye nefilimu yangaphambili. Eli nqaku liza kuxubusha ngokweenkcukacha inkqubo yokuchithwa kunye nokudumba kwe-HPMC emanzini, kunye nokubaluleka kwayo kwizicelo ezahlukeneyo.
1. Ubume kunye neepropati ze-HPMC
I-HPMC yi-ether ye-cellulose engekho i-ionic eyenziwa yi-chemical modification ye-cellulose. Ubume bayo beekhemikhali buqulethe i-methyl kunye ne-hydroxypropyl substituents, ezithatha indawo yamaqela e-hydroxyl kwikhonkco ye-cellulose ye-molecular, enika iimpawu ze-HPMC ezahlukileyo kwezo ze-cellulose yendalo. Ngenxa yobume bayo obukhethekileyo, i-HPMC inezi mpawu zilandelayo:
Ukunyibilika kwamanzi: I-HPMC inokunyibilika emanzini abandayo kunye nashushu kwaye ineempawu eziqinileyo zokujiya.
Uzinzo: I-HPMC inokuguquguquka okubanzi kumaxabiso e-pH kwaye inokuhlala izinzile phantsi kweemeko zombini ze-asidi kunye ne-alkaline.
I-Thermal Gelation: I-HPMC ineempawu ze-thermal gelation. Xa ubushushu buphakama, isisombululo samanzi se-HPMC siya kwenza ijeli kwaye sinyibilike xa ubushushu buhla.
2. Indlela yokwandiswa kweHPMC emanzini
Xa i-HPMC idibana namanzi, amaqela e-hydrophilic kwitsheyini yawo yemolekyuli (efana ne-hydroxyl kunye ne-hydroxypropyl) iya kusebenzisana neemolekyuli zamanzi ukwenza iibhondi ze-hydrogen. Le nkqubo yenza ikhonkco lemolekyuli yeHPMC ngokuthe ngcembe ifunxe amanzi kwaye yandise. Inkqubo yokwandiswa kwe-HPMC inokohlulwa ngokwezi zigaba zilandelayo:
2.1 Inqanaba lokuqala lokufunxa amanzi
Xa amasuntswana HPMC kuqala ukudibana namanzi, iimolekyuli zamanzi ziya kungena ngokukhawuleza kumphezulu amasuntswana, ebangela umphezulu amasuntswana ukwandisa. Le nkqubo ibangelwa ikakhulu kwintsebenziswano eqinile phakathi kwamaqela e-hydrophilic kwii-molecule ze-HPMC kunye neemolekyuli zamanzi. Ekubeni i-HPMC ngokwayo ingeyo-ionic, ayiyi kunyibilika ngokukhawuleza njengeepholima ze-ionic, kodwa iya kutsala amanzi kwaye yandise kuqala.
2.2 Inqanaba lokwandiswa kwangaphakathi
Njengoko ixesha lihamba, iimolekyuli zamanzi zingena ngokuthe ngcembe ngaphakathi kweengqungquthela, ezibangela ukuba amakhonkco e-cellulose angaphakathi kwiincinci ziqale ukwanda. Izinga lokwandiswa kwamasuntswana e-HPMC liya kucotha kweli nqanaba ngenxa yokuba ukungena kweeathomli zamanzi kufuneka zoyise ilungiselelo eliqinileyo lamatyathanga emolekyuli ngaphakathi kweHPMC.
2.3 Gqibezela inqanaba lokupheliswa
Emva kwexesha elide elaneleyo, amasuntswana e-HPMC aya kunyibilika ngokupheleleyo emanzini ukwenza isisombululo se-viscous esifanayo. Ngeli xesha, i-molecular chains ye-HPMC igoqwe ngokungenamkhethe emanzini, kwaye isisombululo sigqitywe ngokusebenzisa i-intermolecular interactions. I-viscosity yesisombululo se-HPMC ihambelana ngokusondeleyo nobunzima bayo be-molecular, i-concentration yesisombululo kunye nobushushu bokutshatyalaliswa.
3. Izinto ezichaphazela ukwandiswa nokupheliswa kwe-HPMC
3.1 Ubushushu
Ukuziphatha kokutshatyalaliswa kwe-HPMC kuhambelana ngokusondeleyo nobushushu bamanzi. Ngokuqhelekileyo, i-HPMC inokunyibilika emanzini abandayo kunye namanzi ashushu, kodwa inkqubo yokutshatyalaliswa iziphatha ngendlela eyahlukileyo kumaqondo okushisa ahlukeneyo. Kumanzi abandayo, i-HPMC idla ngokufunxa amanzi kwaye idumbe kuqala, ize inyibilike kancinane; ngelixa kumanzi ashushu, i-HPMC iya kungena kwi-thermal gelation kwiqondo lokushisa elithile, oku kuthetha ukuba yenza ijeli kunesisombululo kwiqondo lokushisa eliphezulu.
3.2 Ukugxininisa
Ukuphakama koxinzelelo lwesisombululo se-HPMC, ukucotha kwesantya sokwandiswa kwamasuntswana, kuba inani leeamolekyu zamanzi kwisisombululo esiphezulu soxinaniso esingasetyenziselwa ukudibanisa kunye ne-HPMC ye-molecular chain chain. Ukongezelela, i-viscosity yesisombululo iya kwanda kakhulu ngokunyuka koxinzelelo.
3.3 Ubungakanani besuntswana
Ubungakanani bamasuntswana e-HPMC bukwachaphazela ukwanda kwayo kunye nesantya sokupheliswa. Amasuntswana amancinane afunxa amanzi kwaye adumbe ngokukhawuleza ngenxa yendawo yawo enkulu ethile, ngelixa amasuntswana amakhudlwana efunxa amanzi ngokucothayo kwaye ethatha ixesha elide ukunyibilika ngokupheleleyo.
3.4 pH ixabiso
Nangona i-HPMC inokuguquguquka okuqinileyo kutshintsho kwi-pH, ukudumba kwayo kunye nokuziphatha kwayo kokunyibilika kunokuchaphazeleka phantsi kweemeko ezineasidi kakhulu okanye ezinealkaline. Ngaphantsi kokungathathi hlangothi ukuya kwiimeko ezibuthathaka kunye ne-alkaline ebuthathaka, inkqubo yokudumba kunye nokuchithwa kwe-HPMC izinzile.
4. Indima ye-HPMC kwizicelo ezahlukeneyo
4.1 Ishishini lezamayeza
Kushishino lwamayeza, i-HPMC isetyenziswa ngokubanzi njenge-binder kunye ne-disintegrant kwiipilisi zamachiza. Ekubeni i-HPMC idumba emanzini kwaye yenza ijeli, oku kunceda ukucotha izinga lokukhululwa kwechiza, ngaloo ndlela kuzuzwe umphumo wokukhululwa olawulwayo. Ukongeza, i-HPMC isenokusetyenziswa njengeyona nxalenye iphambili yokugquma ifilimu yeziyobisi ukomeleza uzinzo lwechiza.
4.2 Izinto zokwakha
I-HPMC ikwadlala indima ebalulekileyo kwimathiriyeli yokwakha, ngakumbi njengento etyebisayo kunye nokugcina amanzi kudaka lwesamente kunye negypsum. Ipropathi yokuvuvukala ye-HPMC kwezi zinto yenza ukuba igcine umswakama kwiqondo lokushisa eliphezulu okanye kwindawo eyomileyo, ngaloo ndlela ikhusela ukubunjwa kweentanda kunye nokuphucula amandla okubambisana kwezinto.
4.3 Ishishini lokutya
Kwishishini lokutya, i-HPMC isetyenziswa njenge-thickener, emulsifier kunye ne-stabilizer. Ngokomzekelo, kwiimpahla ezibhakiweyo, i-HPMC inokuphucula ukuzinza kwentlama kunye nokuphucula ukuthungwa kunye nencasa yemveliso. Ukongeza, iipropati zokudumba ze-HPMC zingasetyenziselwa ukuvelisa ukutya okunamafutha aphantsi okanye amanqatha-free ukwandisa ukuhlutha kunye nokuzinza.
4.4 Izithambiso
Kwizinto zokuthambisa, i-HPMC isetyenziswa kakhulu kwiimveliso zokhathalelo lolusu, iishampu kunye nezicondisi-moya njengento etyebisayo kunye nezinzisi. Ijeli eyenziwe ngokwandiswa kwe-HPMC emanzini inceda ukuphucula ukuthungwa kwemveliso kwaye yenza ifilimu ekhuselayo eluswini ukugcina ulusu lumanzi.
5. Isishwankathelo
Ipropati yokudumba ye-HPMC emanzini sisiseko sokusetyenziswa kwayo ngokubanzi. HPMC iyanda ngokufunxa amanzi ukwenza isisombululo okanye ijeli kunye viscosity. Le propati yenza ukuba isetyenziswe ngokubanzi kwiinkalo ezininzi ezifana namayeza, ukwakhiwa, ukutya kunye nezithambiso.
Ixesha lokuposa: Oct-09-2024