IHydroxypropyl methylcellulose (HPMC) yi-nonionic cellulose ether eyenziwe kwi-cellulose ngokuguqulwa kweekhemikhali. Njengezinto ezibalulekileyo zepolymer ezinyibilikayo emanzini, i-HPMC isetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, izinto zokuthambisa kunye nezinye iinkalo. Ukuziphatha kwe-HPMC emanzini kubaluleke kakhulu kuba imisela umphumo wesicelo sayo kwisisombululo, kubandakanywa ukuqina, ukumiswa, ukudibanisa kunye nokukwazi ukwenza ifilimu.
HPMC ukudumba indlela emanzini
I-HPMC iya kudumba kakhulu emanzini. Oku kudumba kubangelwa ikakhulu kukudibana kwe-hydrogen phakathi kwe-hydroxyl kunye namaqela e-methoxy kwisakhiwo semolekyuli ye-HPMC kunye neemolekyuli zamanzi. Xa i-HPMC idibana namanzi, iimolekyuli zamanzi ziya kungena phakathi kwamacandelo ekhonkco leemolekyuli ze-HPMC, zaphule iibhondi ze-hydrogen phakathi kweeathom, zolule amacandelo ekhonkco kunye nokwandisa umthamo we-molecular. Le nkqubo yinto esiyibiza ngokuba yinto "yokudumba".
Ngokukodwa, xa i-HPMC idumba emanzini, iqala ukufunxa amanzi kwaye iqalise ukudumba, kwaye ngokuthe ngcembe yenza isisombululo se-viscous colloidal. Le nkqubo ibandakanya izigaba ezibini eziphambili: enye yinqanaba lokuqala lokudumba elikhawulezayo, kwaye elinye linqanaba lokunyibilika elicothayo. Kwinqanaba lokuqala, i-HPMC ifunxa amanzi ukwenza iihydrates ezidumbileyo, inkqubo edla ngokugqitywa kwimizuzu embalwa. Kweli nqanaba, iimolekyuli zamanzi zingena ngokukhawuleza kwiincinci ze-HPMC, ezibangela ukuba umthamo wabo wande. Njengoko amanzi engena ngakumbi, iimolekyuli ze-HPMC ngokuthe ngcembe zahlukana namasuntswana aqinileyo kwaye zingena kwisisombululo ukwenza isisombululo esinamanzi esifanayo.
Izinto ezichaphazela ukudumba kwe-HPMC emanzini
Ubushushu: Ubushushu bunempembelelo ebalulekileyo ekuziphatheni ukudumba kwe-HPMC emanzini. Ngokuqhelekileyo, njengoko ubushushu bukhula, izinga lokuchithwa kwe-HPMC liyakhawuleza kwaye iqondo lokudumba libonakala ngakumbi. Oku kungenxa yokuba amandla e-kinetic yeemolekyuli zamanzi anyuka kumaqondo aphezulu, okwenza kube lula ukungena phakathi kwamacandelo eemolekyuli ze-HPMC kunye nokukhuthaza ukwanda kwazo. Nangona kunjalo, ubushushu obuphezulu kakhulu bunokubangela ukuthotywa kwenxalenye ye-HPMC kwaye kuchaphazele iimpawu zayo zokunyibilika.
Ibakala le-Viscosity: I-HPMC ineentlobo ngeentlobo zamabakala e-viscosity. Ukuphakama kwe-viscosity ye-HPMC, kokukhona i-viscous yesisombululo se-colloidal xa idumba emanzini. Xa HPMC ngebanga eliphezulu viscosity ukudumba, iimolekyuli zamanzi ukungena ngokucothayo kunye nenkqubo unyibiliko ngokuhambelana elide. I-HPMC enebakala eliphantsi le-viscosity kulula ukuyinyibilika kwaye yenza isisombululo esincinci.
Ixabiso le-pH yesisombululo: I-HPMC inokuguquguquka okuthile kwixabiso le-pH. I-HPMC inesiphumo esingcono sokudumba phantsi kweemeko zeasidi ezingathathi hlangothi okanye ezibuthathaka. Ngaphantsi kwe-asidi eqinile okanye iimeko ezinamandla ze-alkaline, i-molecular structure ye-HPMC inokutshintsha, ngaloo ndlela ichaphazela ukudumba kwayo kunye nokuziphatha kwayo.
Ugxininiso: Ukuxinana kwesisombululo se-HPMC emanzini kukwachaphazela ukuziphatha kwayo ukudumba. Kwiindawo ezisezantsi, i-HPMC kulula ukunyibilika ngokupheleleyo kwaye yenze isisombululo esifanayo. Kwiindawo eziphezulu, intsebenziswano phakathi kwee-molecule ze-HPMC zonyuka, ezinokubangela ukuba ezinye iimolekyuli zibe nzima ukunyibilika ngokupheleleyo emanzini kwaye zenze iibhloko zejeli.
Ukusetyenziswa okusebenzayo kokudumba kweHPMC
Iimpawu zokudumba ze-HPMC zidlala indima ebalulekileyo kwizicelo ezibonakalayo. Ngokomzekelo, kwishishini lamachiza, i-HPMC isetyenziswa ngokubanzi kwiipilisi ezikhutshwa ngokuzinzileyo. Ngenxa yokuba idumba emanzini ukwenza ifilimu ye-colloidal, inokulawula ngokufanelekileyo izinga lokukhutshwa kwechiza, ngaloo ndlela yandisa ixesha lesenzo sechiza.
Kushishino lolwakhiwo, i-HPMC isoloko isetyenziswa njengento ejiyayo kunye nokugcina amanzi kwisamente kunye nemathiriyeli esekwe kwigypsum. Iimpawu zayo zokuvuvukala zinokuphucula ukubambelela kunye nokusebenza kokwakhiwa kwezixhobo, ngelixa likwagcina umswakama, ukwandisa ixesha lokumisela izinto, kunye nokuphucula amandla omatshini kunye nokugudiswa komhlaba kweemveliso ezigqityiweyo.
Kwimizi-mveliso yokutya kunye nezithambiso, i-HPMC ikwadlala indima ebalulekileyo njenge-thickener kunye ne-stabilizer. Ukuziphatha kwayo ukudumba kunokunika ukutya incasa engcono kunye nokuthungwa, ngelixa kwizinto zokuthambisa, i-HPMC inceda ukwenza umphumo wesicelo esifanayo kunye nokugcina ukufuma.
Ukuziphatha kokudumba kwe-HPMC emanzini sisiphumo sokusebenzisana phakathi kwesakhiwo sayo sekhemikhali kunye neamolekyu zamanzi. Ngokulungelelanisa izinto ezifana nokushisa, ixabiso le-pH, ibakala le-viscosity kunye nokugxininiswa kwesisombululo, inkqubo yokuvuvukala kunye nokutshatyalaliswa kwe-HPMC emanzini inokulawulwa ukuhlangabezana neemfuno zeendawo ezahlukeneyo zesicelo. Le propati yokudumba ye-HPMC isetyenziswa ngokubanzi kumashishini amaninzi, ebonisa ukubaluleka kwayo njengento esebenzayo yepolymer.
Ixesha lokuposa: Aug-29-2024