I-Hydroxypropyl methylcellulose (HPMC) yinto eqhelekileyo esetyenziswa kwi-polymer compound, esetyenziswa ngokubanzi kumayeza, ukutya, ukwakhiwa, iimveliso zokunyamekela komntu kunye nezinye iinkalo. iimpawu zayo ezizodwa zenza HPMC ixabiso elikhulu izicelo ezininzi.
1. Iimpawu zeMichiza kunye nesakhiwo
I-HPMC yenziwe ngokuguqulwa kweekhemikhali zeselulosi, ikakhulu ngokusabela kwamaqela e-hydroxyl yeselulosi endaweni. Isakhiwo sayo se-molecular iqukethe amaqela asebenzayo afana ne-hydroxypropyl kunye ne-methyl, eyenza ibe ne-solubility yamanzi, i-viscosity kunye ne-film-forming properties. Isisombululo se-colloidal esakhiwe yi-HPMC emanzini singenza ifilimu ecacileyo phantsi kweemeko ezithile, ezibeka isiseko sokusetyenziswa kwayo kwiinkalo ezininzi.
2. Iindawo zesicelo eziphambili
Amalungiselelo amachiza I-HPMC isetyenziswa ngokubanzi kumalungiselelo amayeza, ngokukodwa njenge-thickener, emulsifier kunye ne-agent-forming agent. Inokuphucula ngokufanelekileyo ukunyibilika kunye ne-bioavailability yamachiza kunye nokwandisa uzinzo lwamachiza. Ukongeza, i-HPMC ikwasetyenziswa ngokuqhelekileyo ekukhutshweni okuzinzileyo kunye nokulawulwa-ukukhululwa kwamalungiselelo ukulungisa izinga lokukhutshwa kwechiza.
Ishishini lokutya Kushishino lokutya, i-HPMC isoloko isetyenziswa njenge-thickener kunye ne-emulsifier. Inokuphucula incasa kunye nokuthungwa kokutya, yandise ubomi beshelufu, kwaye iphucule ukuzinza kokutya. Umzekelo, i-HPMC inokuthintela ukubunjwa kweekristale zomkhenkce kwi-ayisikrimu kunye neemveliso zobisi, ukugcina incasa egudileyo yemveliso.
Izinto zokwakha Kushishino lokwakha, iHPMC isoloko isetyenziswa njengesongezo sesamente nodaka. Inokuphucula ukusebenza kolwakhiwo lodaka, yandise ukugcinwa kwayo kwamanzi kunye nokunamathela, kwaye iphucule ukumelana nokuqhekeka kunye namandla oxinzelelo. Ukongezwa kwe-HPMC kwenza ukuba udaka luncinci ukuqhekeka ngexesha lokumisa, ngaloo ndlela ukwandisa ubomi benkonzo yezinto zokwakha.
Iimveliso zokhathalelo lomntu Kwiimveliso zokhathalelo lomntu, ezinje ngeekhrimu zesikhumba, ishampu, iijeli zeshawa, njl.njl., I-HPMC isoloko isetyenziswa njengento etyebisayo kunye nefilimu yangaphambili. Inokunyusa ukuhambelana kwemveliso kunye nokuphucula amava omsebenzisi, ngelixa isenza ifilimu ekhuselayo kwindawo yesikhumba ukuze kuphuculwe umphumo wokunyusa imveliso.
3. Izinto eziluncedo
Ukunyibilika okugqwesileyo kunye nokujiya i-HPMC inokunyibilika kakuhle emanzini kwaye inokwenza isisombululo se-colloidal esizinzileyo kwiindawo ezahlukeneyo, kunye nesiphumo esihle sokuqina. I-viscosity yayo inokulawulwa ngokulungelelanisa ugxininiso kunye nokushisa ukuhlangabezana neemfuno ezahlukeneyo zesicelo.
I-Biocompatibility HPMC yipolymer e-non-ionic yamanzi e-soluble kunye ne-biocompatibility efanelekileyo kwaye akukho kuphazamiseka kwesikhumba kunye nomzimba womntu, ngoko ke isetyenziswa ngokubanzi kumayeza kunye neemveliso zokhathalelo lomntu.
Ukulawula ukukhutshwa kweziyobisi i-HPMC inokulungelelanisa izinga lokukhululwa kwamachiza kumalungiselelo amayeza ngokuguqula ukugxininiswa kwayo kunye nobunzima be-molecular, kwaye ifanelekile ukulungiselela ukukhutshwa okuzinzileyo kunye nokulawulwa kokukhululwa kwamalungiselelo. Olu phawu lubaluleke kakhulu kuphando lweziyobisi kunye nophuhliso, olunokuphucula ukusebenza kwamachiza kunye nokunciphisa iziphumo ebezingalindelekanga.
Ukhuseleko lokusingqongileyo I-HPMC iguqulwe kwi-cellulose yezityalo zendalo kwaye ineempawu ezithile zokukhusela okusingqongileyo, ezihambelana nombono wekhemistri eluhlaza. Xa kuthelekiswa neepolima zokwenziwa, i-HPMC inempembelelo encinci kokusingqongileyo.
4. Imingeni yesicelo kunye nezalathiso zophuhliso
Nangona i-HPMC isetyenziswa ngokubanzi kwiinkalo ezininzi, kusekho imingeni ekusetyenzisweni okwenyani. Umzekelo, kumalungiselelo amayeza, isiphumo sokuqina kwe-HPMC sinokuchaphazeleka bubushushu kunye ne-pH, ngoko ke uqwalaselo ngononophelo luyafuneka kuyilo lwefomula. Ukongeza, ngokunyuka kwemfuno yabathengi kwimveliso yendalo kunye neluhlaza, ukhuphiswano lwentengiso ye-HPMC nalo luya lusiba lubi kakhulu.
Umkhombandlela wophuhliso we-HPMC unokujolisa ekuphuhliseni itekhnoloji yokuguqula ukuphucula ukusebenza kwayo kunye nokuziqhelanisa. Kwangaxeshanye, ukudibanisa uphando lwezixhobo ezitsha ukuphuhlisa i-derivatives ye-HPMC esebenzayo kunye nokusebenza ngakumbi kuya kuba yinto ebalulekileyo kwixesha elizayo.
IHydroxypropyl methylcellulose iye yaba sisongezo esiyimfuneko kumashishini amaninzi ngenxa yeepropathi zayo zekhemikhali ezigqwesileyo kunye nokuguquguquka. Nokuba kumalungiselelo amayeza, ishishini lokutya, okanye izinto zokwakha kunye neemveliso zokhathalelo lomntu, ukusetyenziswa kwe-HPMC kubonise ukubaluleka kunye nobubanzi bayo. Ngenkqubela phambili eqhubekayo yesayensi kunye nethekhinoloji, indawo yokusetyenziswa kwe-HPMC kulindeleke ukuba yande ngakumbi, izise ukuveliswa kwezinto ezintsha kunye namathuba ophuhliso kumashishini ahlukeneyo.
Ixesha lokuposa: Oct-12-2024