Loluphi uhlobo lwepholima iHPMC?

I-HPMC, okanye i-hydroxypropyl methylcellulose, luhlobo lwe-polymer esekwe kwi-cellulose esetyenziswa kakhulu kumachiza, ukutya, kunye namashishini okunyamekela. I-Cellulose yipolima yendalo efumaneka kwizityalo kwaye yeyona nto ininzi emhlabeni. Yipolima elungelelanisiweyo eyenziwe ngee-glucose monomers ezidityaniswe nge-β(1→4) glycosidic bonds.

I-HPMC iveliswa ngokuguqula iikhemikhali zeselulosi nokuba ngamaqela e-methyl okanye e-hydroxypropyl. Olu hlengahlengiso lunokwenziwa ngokuphendula i-cellulose kunye ne-reagents efanelekileyo phambi kwe-catalyst ye-asidi. Ukusabela phakathi kwe-cellulose kunye ne-methyl chloride okanye i-methyl bromide ivelisa i-methylcellulose, ngelixa ukuphendula phakathi kwe-cellulose kunye ne-propylene oxide ivelisa i-hydroxypropyl cellulose. I-HPMC iveliswa ngokudibanisa ezi mpendulo zimbini ukwazisa omabini amaqela e-methyl kunye ne-hydroxypropyl kwi-cellulose backbone.

I-polymer ebangelwayo inesakhiwo esiyinkimbinkimbi esinokuhluka ngokuxhomekeke kwiqondo lokutshintshwa (DS) kwe-methyl kunye namaqela e-hydroxypropyl. I-DS ibhekisa kwiavareji yenani lamaqela e-hydroxyl endaweni nganye kwiyunithi ye-anhydroglucose kwi-cellulose backbone. Ngokuqhelekileyo, i-HPMC ine-DS ye-1.2 ukuya kwi-2.5 kumaqela e-methyl kunye ne-0.1 ukuya kwi-0.3 kumaqela e-hydroxypropyl. Ubume be-HPMC buntsonkothe ​​ngakumbi kukuba amaqela e-methyl kunye ne-hydroxypropyl anokuhanjiswa ngokungenamkhethe ecaleni komqolo we-cellulose, okukhokelela kwipolymer engafaniyo enoluhlu lweempawu.

I-HPMC yipolima enyibilikayo emanzini eyenza into efana nejeli xa ifakwe emanzini. Iimpawu ze-gelation ze-HPMC zixhomekeke kwizinto ezininzi, ezibandakanya i-DS, ubunzima be-molecular, kunye noxinzelelo lwepolymer. Ngokubanzi, i-HPMC yenza ijeli ezinzile ngakumbi kwiindawo eziphezulu kunye namaxabiso aphezulu e-DS. Ukongeza, iipropathi ze-gelation ze-HPMC zinokuphenjelelwa yi-pH, amandla e-ionic, kunye nobushushu besisombululo.

Iimpawu ezizodwa ze-HPMC zenza ukuba ibe yinto exabisekileyo kwizicelo ezininzi. Kwishishini lamachiza, i-HPMC isetyenziswa njenge-binder, i-disintegrant, kunye ne-ejenti yokwenza ifilimu kwiipilisi kunye nee-capsules. Isenokusetyenziswa ukuguqula izinga lokukhululwa kwamachiza kwifom yedosi. Kwishishini lokutya, i-HPMC isetyenziswa njenge-thickener, stabilizer, kunye ne-emulsifier. Ihlala isetyenziselwa ukutya okunamafutha aphantsi okanye okuncitshisiweyo ukulinganisa ukuthungwa kunye nomlomo wokutya okunamafutha aphezulu. Kwishishini lokhathalelo lomntu, i-HPMC isetyenziswa njenge-thickener, i-ejenti yokwenza ifilim, kunye ne-emulsifier kwiishampu, izinto zokuthambisa, kunye nezinye iimveliso.

Ukuqukumbela, i-HPMC yi-polymer esekwe kwi-cellulose eveliswa ngokuguqula i-cellulose ngamachiza kunye namaqela e-methyl kunye ne-hydroxypropyl. I-polymer ebangelwayo i-soluble yamanzi kwaye inesakhiwo esiyinkimbinkimbi esinokuhluka ngokuxhomekeka kwinqanaba lokutshintshwa kunye nokusabalalisa kwamaqela e-methyl kunye ne-hydroxypropyl. I-HPMC yipolymer eguquguqukayo enezicelo ezininzi kumayeza, ukutya, kunye namashishini okhathalelo lomntu.