IHydroxypropyl methylcellulose (HPMC) sisixhobo esisebenza ngeendlela ezininzi esisetyenziswa kakhulu kumayeza, kumashishini okutya nakwizinto zokuthambisa. Le derivative ye-cellulose iphuma kwi-cellulose yendalo kwaye iguqulelwe ukufezekisa iipropati ezithile, okwenza ibe yinto eyimfuneko kwiindlela ezahlukeneyo zokuqulunqa.
1. Intshayelelo ngeHydroxypropyl Methylcellulose (HPMC)
1.1. Ubume bemichiza kunye neempawu
IHydroxypropylmethylcellulose yipolymer eyisemi-synthetic ephuma kwiselulosi, eyona nxalenye yesakhiwo seendonga zesityalo. Ubume bekhemikhali be-HPMC bubandakanya iiyunithi ze-cellulose backbone ezidityaniswe ne-hydroxypropyl kunye namaqela e-methyl. Iqondo lokutshintshwa kwala maqela lichaphazela ukunyibilika, i-viscosity, kunye nezinye iimpawu ezibonakalayo zepolymer.
HPMC idla ngokuba mhlophe okanye off-mhlophe ngenkangeleko, ivumba kwaye incasa. I-soluble emanzini kwaye iifom ezicacileyo, izisombululo ze-viscous, okwenza ukuba zixabiseke kwiintlobo ezahlukeneyo zezicelo.
1.2. Inkqubo yokuvelisa
Ukuveliswa kwe-hydroxypropyl methylcellulose kubandakanya i-etherification ye-cellulose usebenzisa i-propylene oxide kunye ne-methyl chloride. Le nkqubo itshintsha amaqela e-hydroxyl kumatyathanga e-cellulose, ekhokelela ekusekweni kwe-hydroxypropyl kunye namaqela e-methyl ether. Ukulawula iqondo lokutshintshwa ngexesha lenkqubo yokwenziwa kwenza kube lula ukwenza iipropati zeHPMC.
2. Iimpawu zomzimba kunye neekhemikhali
2.1. Ukunyibilika kunye ne-viscosity
Enye yezinto eziphambili ze-HPMC kukunyibilika kwayo emanzini. Isantya sokuchithwa sixhomekeke kwiqondo lokutshintshwa kunye nobunzima bemolekyuli. Le ndlela yokuziphatha ye-solubility yenza ukuba ifaneleke kwiintlobo ezahlukeneyo zokuqulunqa ezifuna ukukhululwa okulawulwayo okanye ukubunjwa kwe-gel.
I-viscosity yezisombululo ze-HPMC nayo iyahlengahlengiswa, ukusuka kumabanga aphantsi ukuya kumabakala aphezulu e-viscosity. Le propati ibaluleke kakhulu ekulungiseni iimpawu ze-rheological zokwakheka ezifana ne-creams, i-gel kunye nezisombululo ze-ophthalmic.
2.2. Ukusebenza kwefilimu
I-HPMC yaziwa ngobuchule bayo bokwenza ifilim, iyenza ibe sisithako esifanelekileyo sokugquma iipilisi kunye neegranules. Ifilimu ebangelwayo ibonakala ngokucacileyo kwaye iguquguqukayo, inika uluhlu olukhuselayo lwesithako seyeza esisebenzayo (API) kunye nokukhuthaza ukukhululwa okulawulwayo.
2.3. Ukuzinza kwe-Thermal
I-Hydroxypropyl methylcellulose inozinzo oluhle lwe-thermal, evumela ukuba imelane noluhlu olubanzi lwamaqondo obushushu adibana nawo ngexesha leenkqubo zokuvelisa. Le propati iququzelela ukuveliswa kweefom zedosi eqinile, kubandakanywa iipilisi kunye neepilisi.
3. Ukusetyenziswa kwe-hydroxypropyl methylcellulose
3.1. Ishishini lamachiza
I-HPMC isetyenziswa ngokubanzi kwintsimi yoxubo-mayeza njenge-excipient kwi-tablet formulations kwaye ineendlela ezahlukeneyo zokusetyenziswa. Isebenza njenge-binder, ilawula ukuchithwa kunye nokukhululwa kwezithako ezisebenzayo. Ukongezelela, iimpawu zayo zokwenza ifilimu zenza ukuba zilungele iipilisi zokugubungela ukubonelela ngoluhlu olukhuselayo.
Kwimixube yolwelo ngomlomo, i-HPMC ingasetyenziswa njenge-arhente yokumisa, i-thickener, okanye ukulungelelanisa i-viscosity. Ukusetyenziswa kwayo kwizisombululo ze-ophthalmic kuyaphawuleka kwiimpawu zayo ze-mucoadhesive, eziphucula i-ocular bioavailability.
3.2. Ishishini lokutya
Ishishini lokutya lisebenzisa i-HPMC njengento etyebisayo kunye nejeli kwiimveliso ezahlukeneyo. Ukukwazi ukwenza iigels ezicacileyo kunye nokulawula i-viscosity kwenza ukuba kubaluleke kakhulu kwizicelo ezifana ne-sauces, ukugqoka kunye ne-confectionery. I-HPMC ihlala ikhethwa ngaphezu kwee-thickeners zemveli ngenxa yokuguquguquka kwayo kunye nokungabikho kwempembelelo kwiimpawu zemvakalelo yeemveliso zokutya.
3.3. Izithambiso kunye neemveliso zokhathalelo lomntu
Kwizinto zokuthambisa, i-HPMC isetyenziselwa ukutyeba, ukuzinzisa kunye neempawu zokwenza ifilimu. Ngokuqhelekileyo ifumaneka kwiikhrimu, izithambiso, kunye neemveliso zokunakekelwa kweenwele. Ikhono lepolymer lokuphucula ukuthungwa kunye nokuzinza kweendlela zokwenza igalelo ekusetyenzisweni kwayo ngokubanzi kwishishini lezinto zokuthambisa.
3.4. Ishishini lokwakha
I-HPMC isetyenziswa kushishino lokwakha njenge arhente yokugcina amanzi kwisamente esekwe kwisamente kunye nemathiriyeli esekwe kwigypsum. Umsebenzi wayo kukwandisa ukuqhubekeka, ukuthintela iintanda, kunye nokuphucula ukunamathela.
4. Iingqwalasela zolawulo kunye neprofayili yokhuseleko
4.1. Ubume bolawulo
IHydroxypropyl methylcellulose ngokuqhelekileyo ibonwa njengekhuselekile (GRAS) zii-arhente ezilawulayo ezifana ne-US Food and Drug Administration (FDA) kunye ne-European Food Safety Authority (EFSA). Idibana nemigangatho eyahlukeneyo ye-pharmacopoeial kwaye idweliswe kwiimonographs zabo.
4.2. Isishwankathelo sokhuseleko
Njengoko excipient esetyenziswa ngokubanzi, HPMC has a iprofayile yokhuseleko elungileyo. Nangona kunjalo, abantu abane-allergies eyaziwayo kwi-cellulose derivatives kufuneka balumke. Ukugxininiswa kwe-HPMC kwifomula kulawulwa ngokungqongqo ukuqinisekisa ukhuseleko, olubalulekileyo ebantwini. Abavelisi bahambelana nezikhokelo ezisekiweyo.
5. Isiphelo kunye namathemba exesha elizayo
I-Hydroxypropyl methylcellulose iye yavela njenge-excipient eguquguqukayo kunye nezicelo ezininzi kwi-pharmaceutical, ukutya, izimonyo kunye namashishini okwakha. Inhlanganisela yayo ekhethekileyo ye-solubility, ulawulo lwe-viscosity kunye neempawu zokwenza ifilimu zenza ukuba ibe yinto exabisekileyo kwiifom ezininzi.
Uphando oluqhubekayo kunye nophuhliso kwicandelo lesayensi yepolymer kunokukhokelela kwinkqubela phambili yokusebenza kwe-HPMC ukuhlangabezana neemfuno ezithile zeshishini. Njengoko imfuno yokuqulunqwa kokukhutshwa okulawulwayo kunye nophuhliso lwemveliso entsha iqhubeka nokukhula, i-hydroxypropyl methylcellulose kunokwenzeka ukuba igcine indima yayo ebalulekileyo njengomncedisi oguquguqukayo.
Ixesha lokuposa: Jan-15-2024