IHydroxypropyl methylcellulose (HPMC) yimathiriyeli yepolymer edla ngokusetyenziswa kumalungiselelo amayeza.Ngenxa yeempawu zayo ezibalaseleyo zomzimba kunye neekhemikhali, idlala indima ebalulekileyo kwimveliso yethebhulethi.I-HPMC ingasetyenziswa njengefilimu yangaphambili, i-arhente yokukhululwa elawulwayo, i-adhesive, thickener, njl., inika iipilisi isakhiwo esihle kunye nomsebenzi.
1. Ifilimu yangaphambili
Indima ye-HPMC njengefilimu yangaphambili ibonakaliswa ikakhulu kwi-coating engaphezulu yeepilisi ezikhutshwayo ezilawulwayo.Itheyibhile yokugqoka iqhutywe ngenjongo yokulawula izinga lokukhululwa kweziyobisi, ukukhusela iziyobisi kwiimpembelelo zendalo, kunye nokuphucula ukubonakala kweziyobisi.Kumalungiselelo okukhululwa okulawulwayo, ifilimu eyenziwe yi-HPMC inokulungelelanisa izinga lokukhululwa kweziyobisi, iqinisekise ukuba amachiza akhululwa kwiindawo ezithile zendlela yesisu, kwaye afezekise umphumo ongcono wonyango.
Indlela yokwenza: Umboniso bhanyabhanya owenziwe yifilimu ye-HPMC yangaphambili unokuzuza ukukhutshwa okulawulwayo kwamachiza ngokulawula ukungena kwezinyibilikisi kunye nokutshatyalaliswa kwamachiza.Ubunzima kunye nokubunjwa kwefilimu kunokulungelelanisa izinga lokuchithwa ukuhlangabezana neemfuno zokukhutshwa kwamachiza ahlukeneyo.
Impembelelo: Iipilisi ezisebenzisa i-HPMC njenge-agent eyenza ifilimu zinokunyibilika kancinane esiswini, zithintele ukukhutshwa kweziyobisi ngesiquphe, ziphucule ukusetyenziswa kweziyobisi, kwaye zinciphise ukucaphuka kweziyobisi kwindlela yesisu.
2. I-arhente yokukhululwa elawulwayo
I-HPMC isoloko isetyenziswa njengesixhobo se-matrix kwiipilisi ezikhutshwayo ezilawulwayo ukulawula izinga lokukhululwa kwamachiza ngokwenza umqobo wejeli.Indima ye-arhente ekhutshweyo elawulwayo kukuqinisekisa ukuba ichiza likhutshwa ngokulinganayo ngexesha elithile ukuze kugcinwe ukugxila okusebenzayo kwechiza emzimbeni, ukunciphisa inani lamaxesha okudosa, kunye nokuphucula ukuthotyelwa kwesigulane.
I-Mechanism of action: Kwimithombo yeendaba ezinamanzi, i-HPMC inokukhawuleza i-hydrate kwaye yenze i-colloidal network structure, elawula ukusabalalisa kunye nesantya sokukhululwa kweyeza.Xa ithebhulethi idibana namanzi, i-HPMC ifunxa amanzi kwaye idumbe ukuze yenze umaleko wejeli, apho iyeza lisasazeka ngaphandle komzimba, kwaye izinga lokukhululwa lixhomekeke kubunzima kunye nobuninzi bomgangatho wejeli.
Impembelelo: I-HPMC njenge-arhente elawulwayo-ekhutshiweyo inokuzinzisa izinga lokukhutshwa kwechiza, ukunciphisa ukuguquguquka koxinaniso lweziyobisi zegazi, kunye nokubonelela ngesiphumo esizinzileyo sonyango, ngakumbi kumachiza onyango lwezifo ezingapheliyo.
3. Izibophelelo
Kwinkqubo yokulungiswa kwethebhulethi, i-HPMC isoloko isetyenziswa njenge-binder ukunyusa amandla omatshini weepilisi kunye nokuqinisekisa ukunyaniseka kweepilisi ngexesha lokugcinwa, ukuthutha kunye nokulawula.
Indlela yokwenza: I-HPMC, njenge-binder, inokwenza i-bond eyomeleleyo phakathi kwamaqhekeza, ukwenzela ukuba i-powders okanye i-particles idibaniswe kwaye yenziwe ibe yithebhulethi eqinile.Le nkqubo idla ngokuqhutyelwa ngeteknoloji ye-granulation emanzi, apho i-HPMC inyibilika kwisisombululo samanzi ukwenza isisombululo se-viscous, kwaye yenza ithebhulethi ezinzileyo emva kokumisa.
Impembelelo: Izibophelelo ze-HPMC zinokuphucula amandla oxinzelelo kunye nobunzima beepilisi, ukunciphisa umngcipheko wokuqhekeka okanye ukuhlukana, kwaye ngaloo ndlela kuphuculwe umgangatho kunye nokuzinza kweepilisi.
4. Izityebi
I-HPMC ingasetyenziswa njenge-thickener kumalungiselelo olwelo ukulungelelanisa iipropati ze-rheological zamalungiselelo kunye nokwandisa i-viscosity.
Indlela yokusebenza: I-HPMC ine-viscosity ephezulu emanzini kwaye inokunyusa ngokufanelekileyo i-viscosity yolwelo, iphucule ukunqunyanyiswa kunye nokuzinza kwechiza, kunye nokuthintela intlenga.
Impembelelo: Ukongeza i-HPMC kumachiza angamalwelo kunokuphucula ukufana kwechiza, ukwenza amacandelo echiza asasazwe ngokulinganayo kulo lonke ulungiselelo, kwaye uqinisekise idosi engaguqukiyo ixesha ngalinye.
Iimpawu zeHydroxypropyl Methylcellulose
1. IiPropati zePhysical and Chemical
I-HPMC yi-ether ye-cellulose ye-nonionic ene-solubility efanelekileyo yamanzi kunye ne-thermal gelation.Ichithwa ngokukhawuleza emanzini abandayo ukwenza isisombululo esicacileyo, ngelixa xa ishushu, isisombululo sijika sibe yi-gel.
2. I-Biocompatibility
I-HPMC ine-biocompatibility elungileyo kunye nokhuseleko, kwaye ayithandeki ukuba ibangele impendulo yomzimba okanye imiphumo eyityhefu, ngoko isetyenziswa ngokubanzi kumasimi amayeza kunye nokutya.
3. Uzinzo lokusingqongileyo
I-HPMC inozinzo oluhle kwizinto zokusingqongileyo ezifana nobushushu kunye nexabiso le-pH, kwaye ayifuni ukuthotywa okanye ukuchithwa, okuqinisekisa ukuzinza kwamalungiselelo eziyobisi ngexesha lokugcinwa.
Imizekelo yeSicelo seHPMC kwiitafile
1. IiTablets eziLawulwayo zokuKhupha
Ngokomzekelo, kwiipilisi ze-nifedipine eziqhubekayo ezisetyenziselwa ukunyanga uxinzelelo lwegazi, i-HPMC isetyenziswe njengento ye-matrix ukulawula ukukhutshwa okucothayo kweyeza, ukunciphisa ukuphindaphinda kolawulo, kunye nokuphucula ukuthotyelwa kwesigulane.
2. Iipilisi ezifakwe kwi-Enteric
Kwiipilisi ze-enteric-coated of proton pump inhibitors (ezifana ne-omeprazole), i-HPMC isebenza njenge-agent eyenza ifilimu ukukhusela ichiza ekutshatyalalisweni yi-asidi ye-gastric kunye nokuqinisekisa ukuba iyeza likhutshwa ngokufanelekileyo emathunjini.
3. Iipilisi zomlomo ezinyibilikayo ngokukhawuleza
Kwiipilisi zomlomo ezichithwa ngokukhawuleza kunyango lwe-rhinitis ye-allergies, i-HPMC isebenza njenge-thickener kunye ne-adhesive ukubonelela ngokuchithwa ngokukhawuleza kunye nokukhululwa okufanayo, ukuphucula incasa kunye nokuthatha amava echiza.
I-Hydroxypropyl methylcellulose isetyenziswa ngokubanzi ekulungiseleleni amacwecwe ahlukeneyo ngenxa yendlela egqwesileyo yokwenza ifilimu, ukukhutshwa okulawulwayo, ukuncamathela kunye neempawu ezityebileyo.I-HPMC ayinako nje ukuphucula iipropati zomzimba kunye nokuzinza kweepilisi, kodwa nokwandisa umphumo wonyango wamachiza ngokulungelelanisa izinga lokukhululwa kwamachiza.Ngophuhliso lobuchwephesha bamayeza, ukusetyenziswa kwe-HPMC kuya kuhlukahlukana, kubonelele ngamathuba amaninzi okwenziwa ngokutsha kwamalungiselelo amachiza.
Ixesha lokuposa: Jun-27-2024