I-Hydroxypropyl methylcellulose (HPMC) isetyenziswa ngokubanzi kwi-tablet coating. Njengomxhasi oqhelekileyo wamayeza, unemisebenzi emininzi kunye neenzuzo.
Izinto zokwenza ifilim: I-HPMC yenye yezinto ezisetyenziswa ngokuqhelekileyo ukwenza ifilimu kwimizobo yokugquma ifilimu. Ineempawu ezilungileyo zokwenza ifilimu, amandla efilimu afanelekileyo, umaleko wokugquma ocacileyo, kwaye akulula ukuqhekeka. Iyazinza phantsi kokukhanya, ubushushu kunye nokufuma okuthile, kwaye iyanyibilika kwizinyibilikisi zendalo kunye namanzi. Inempembelelo encinci engalunganga ekuqhekekeni kunye nokuchithwa kwamacwecwe. Ke ngoko, yinto esetyenziswa ngokubanzi kwi-gastric soluble coating material enefuthe elihle lokugquma ifilimu.
Khusela i-API: Ukugquma kwe-HPMC kunokukhusela izithako ezisebenzayo zamachiza (API) kwizinto ezisingqongileyo ezifana nokukhanya, i-oxidation kunye nokufuma, ukuqinisekisa ukuba iyeza linokuqhubeka nokudlala indima yalo ekujoliswe kuyo nasemva kokugcinwa ixesha elide.
Lawula ukukhutshwa kweziyobisi: Ngokugquma ifilimu, abavelisi beziyobisi banokulawula indawo yokukhulula, izinga kunye nexesha le-API. Oku kubaluleke kakhulu kumachiza athile afuna ukukhutshwa ngokulibaziseka, okanye kumachiza ekufuneka akhulule inani eliqhubekayo le-API ngaphakathi kwexesha elithile.
Ukuphucula ukuthotyelwa kwesigulane: Iipilisi ezifakwe kwifilimu zilula ukuthatha, ezinokuphucula ukuthotyelwa kwesigulane.
Phucula inkangeleko yethebhulethi: Ukugquma kwefilimu kunokubonelela ngomphezulu ogudileyo kunye nemibala eqaqambileyo, ukuphucula ukuqondwa kwebrendi kunye namava amayeza esigulane.
Njengesibophelelo kunye ne-disintegrant: I-HPMC ingasetyenziswa njengesibophelelo. Isisombululo sayo se-HPMC se-viscosity ephantsi sinokunciphisa ngokufanelekileyo i-engile yoqhagamshelwano yechiza, ehambelana nokumanzisa iyeza. I-coefficient yokwandisa emva kokufunxa amanzi inokufikelela kumakhulu amaxesha, oko kunokuphucula kakhulu ukuchithwa kunye nokukhutshwa kwesantya sokukhululwa kweyeza.
Ukuphucula uzinzo lwethebhulethi: I-HPMC ine-hygroscopicity ephantsi, enokusetyenziswa njengenzuzo kuba inokunciphisa iingxaki zokuzinza okubangelwa ukufunxa ukufuma ngexesha lokugcinwa kweepilisi.
Njengesixhobo sokukhululwa kwamathambo: Kumalungiselelo okukhululwa okuqhubekayo, i-HPMC ingasetyenziswa njengesixhobo se-hydrophilic skeleton. Ngokulungelelanisa i-viscosity kunye nedosi ye-HPMC, izinga lokukhululwa kwechiza linokulawulwa ukufikelela kwisiphumo esizinzileyo sokukhululwa kwechiza.
Ukuphucula ukunyibilika: Isisombululo se-ethanol se-HPMC okanye isisombululo samanzi sisetyenziswa njenge-agent yokumanzisa i-granulation, esebenzayo ekuphuculeni ukunyibilika kwamacwecwe.
Ukuphucula umgangatho wokugquma: Njengesixhobo sokwenza ifilimu, i-HPMC inenzuzo enkulu ngaphezu kwezinye izinto zokwenza ifilimu kuba i-soluble yamanzi, ayifuni i-solvents eziphilayo, kwaye ikhuselekile kwaye ikulungele ukusebenza. I-HPMC nayo ineentlobo ngeentlobo zenkcazo ye-viscosity. Ukuba isetyenziswe ngokufanelekileyo, umgangatho kunye nokubonakala kweepilisi ezigqunyiweyo zingcono kunezinye izinto.
I-HPMC isetyenziswa ngokubanzi kwi-tablet yokwaleka, engakwazi nje ukuphucula umgangatho kunye nenkangeleko yeepilisi, kodwa nokukhusela ngokufanelekileyo izithako zeziyobisi, ukulawula ukukhutshwa kweziyobisi, kunye nokuphucula ukuthotyelwa kwesigulane.
Ixesha lokuposa: Oct-29-2024