I-HPMC (i-Hydroxypropyl Methylcellulose) yinto esetyenziswa kakhulu kwiyeza, ukutya, izinto zokwakha kunye nezinye iindawo. Iimveliso ze-HPMC zinokwahlulwa zibe ngamacandelo amaninzi ngokweemfuno ezahlukeneyo zesicelo, phakathi kwazo ezona zixhaphakileyo zii-K series kunye no-E series. Nangona zombini ziyi-HPMC, zineeyantlukwano ezithile kulwakhiwo lweekhemikhali, iipropati zomzimba kunye nemimandla yesicelo.
1. Umahluko kwisakhiwo sekhemikhali
Umxholo we-Methoxy: Umahluko omkhulu phakathi kwe-K series kunye ne-E series HPMC ngumxholo wabo we-methoxy. Umxholo we-methoxy we-E series HPMC iphezulu (ngokubanzi i-28-30%), ngelixa umxholo we-methoxy we-K series uphantsi kakhulu (malunga ne-19-24%).
Umxholo we-Hydroxypropoxy: Ngokwahlukileyo, umxholo we-hydroxypropoxy we-K series (7-12%) uphezulu kunoluhlu lwe-E (4-7.5%). Lo mahluko ekubunjweni kweekhemikhali kukhokelela ekuhlukeni ekusebenzeni kunye nokusetyenziswa phakathi kwezi zibini.
2. Umahluko kwiimpawu zomzimba
Ukunyibilika: Ngenxa yomahluko kumxholo we-methoxy kunye ne-hydroxypropoxy, ukunyibilika kochungechunge lwe-K HPMC lungaphantsi kancinci kunoluchungechunge lwe-E, ngakumbi kumanzi abandayo. Uluhlu lwe-E lunyibilika ngakumbi emanzini abandayo ngenxa yomxholo walo ophezulu we-methoxy.
Ubushushu beGel: Ubushushu bejeli bothotho lwe-K buphezulu kunolo lwe-E series. Oku kuthetha ukuba phantsi kweemeko ezifanayo, kuba nzima ngakumbi K series HPMC ukwenza ijeli. Ubushushu bejeli yochungechunge lwe-E buphantsi, kwaye kwezinye izicelo ezithile, ezifana nezixhobo zejeli ze-thermosensitive, uchungechunge lwe-E lungenza ngcono.
Viscosity: Nangona viscosity ikakhulu kuxhomekeke ubunzima molekyuli HPMC, phantsi kweemeko ezifanayo, viscosity E series HPMC idla ngokuba phezulu kunolo K series. Umahluko kwi-viscosity inempembelelo enkulu kwiipropati ze-rheological ngexesha lenkqubo yokulungiselela, ngakumbi xa isetyenziswe kwiingubo kunye nokumiswa.
3. Umahluko kwiinkalo zesicelo
Ngenxa yomahluko kubume beekhemikhali kunye neempawu zomzimba ze-K series kunye no-E series HPMC, izicelo zabo kwiinkalo ezahlukeneyo nazo ziyahluka.
Intsimi yamachiza: Kumalungiselelo amayeza, uchungechunge lwe-E lwe-HPMC luhlala lusetyenziswa njengesithako esiphambili samalungiselelo okukhululwa okuzinzileyo. Oku kungenxa yobushushu bayo obuphantsi be-gelation kunye ne-viscosity ephezulu, eyenza ukuba ilawule ngcono izinga lokukhutshwa kwechiza xa kusenziwa ifilimu ekhutshwe ngokuzinzileyo. Uchungechunge lwe-K lusetyenziswa kakhulu kwiipilisi ezifakwe kwi-enteric kunye ne-capsule eludongeni, kuba ukushisa kwayo okuphezulu kwe-gelation kuthintela ukukhutshwa kweziyobisi kwijusi yesisu, ekhuthaza ukukhutshwa kweziyobisi emathunjini.
Intsimi yokutya: Kushishino lokutya, uchungechunge lwe-E HPMC luhlala lusetyenziswa njenge-thickener, stabilizer kunye ne-emulsifier. Ngenxa yokunyibilika kwayo okuphezulu kunye ne-viscosity efanelekileyo, inokuthi ihlakazeke ngcono kwaye inyibilike ekutyeni. Uluhlu lwe-K lusetyenziswa kakhulu ekutyeni okufuneka kugcinwe uzinzo phantsi kweemeko eziphezulu zokushisa, ezifana neemveliso ezibhakiweyo, ngenxa yokushisa kwayo okuphezulu kwe-gelation.
Intsimi yezinto zokwakha: Kwizinto zokwakha, uchungechunge lwe-K lwe-HPMC ludla ngokusetyenziswa kudaka olomileyo kunye nomgubo we-putty, osebenza njengento yokugcina amanzi kunye ne-thickener, ngakumbi ngezihlandlo ezifuna ukwakhiwa kumaqondo aphezulu. Uluhlu lwe-E lufanelekile ngakumbi kwizinto ezineempawu eziphezulu ze-rheological ezifana nepeyinti yomgangatho kunye neengubo ngenxa yokushisa kwe-gelation ephantsi kunye ne-viscosity ephezulu.
4. Ezinye izinto ezinempembelelo
Ukongeza kulo mahluko ungentla, ukusetyenziswa okuthe ngqo koluhlu olwahlukileyo lwe-HPMC kunokuchatshazelwa zizinto ezinjengobunzima bemolekyuli, iqondo lokuthatha indawo, kunye ne-dispersibility. Ukongezelela, kwizicelo eziphathekayo, ukukhethwa kwe-HPMC kufuneka kwakhona kuthathelwe ingqalelo ukuhambelana kwayo nezinye izithako kunye nefuthe layo ekusebenzeni kwemveliso yokugqibela.
Nangona uchungechunge lwe-K kunye nochungechunge lwe-E lwe-HPMC zombini i-hydroxypropyl methylcellulose, ibonisa umahluko ocacileyo kwiipropati zomzimba kunye neendawo zokusetyenziswa ngenxa yemixholo eyahlukeneyo ye-methoxy kunye namaqela e-hydroxypropoxy. Ukuqonda lo mahluko kubalulekile ekukhetheni uhlobo olululo lwe-HPMC kwizicelo ezibonakalayo.
Ixesha lokuposa: Aug-13-2024