Yintoni ihydroxypropyl methylcellulose efakwe endaweni ephantsi?

I-Low-substituted hydroxypropylmethylcellulose (L-HPMC) i-polymer eguquguqukayo, eguquguqukayo kunye nezicelo kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, ukwakhiwa, kunye nezithambiso. Le khompawundi ivela kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo. Ukuze uqonde i-hydroxypropyl methylcellulose ephantsi endaweni, umntu kufuneka aphule igama layo kwaye ahlolisise iimpawu zayo, ukusetyenziswa, ukudibanisa, kunye nefuthe kumashishini ahlukeneyo.

1. Ukuqonda amagama:

IHydroxypropyl methylcellulose (HPMC):

I-Cellulose yi-carbohydrate eyinkimbinkimbi eyenziwe ngeeyunithi ze-glucose kwaye iyona nxalenye ephambili yeendonga zeeseli zesityalo.

IHydroxypropyl methylcellulose luhlobo olulungisiweyo lweselulosi eye yaphathwa ngokwekhemikhali ukwazisa amaqela e-hydroxypropyl kunye ne-methyl. Olu tshintsho longeza ukunyibilika kwayo kunye nezinye izinto ezinqwenelekayo.

Ufakelo oluphantsi:

Ibhekisa kwiqondo elisezantsi xa kuthelekiswa nezinye izinto eziphuma kwiselulosi, ezifana nezinto eziphuma endaweni ephezulu ezifana ne-hydroxyethyl cellulose (HEC).

2. Ukusebenza:

Ukunyibilika:

I-L-HPMC inyibilika ngakumbi emanzini kuneselulosi.

Viscosity:

I-viscosity yezisombululo ze-L-HPMC inokulawulwa ngokulungelelanisa iqondo lokutshintshwa, okwenza ukuba ilungele uluhlu olubanzi lwezicelo.

Ukwenziwa kwefilimu:

I-L-HPMC inokwenza iifilimu ezibhityileyo, iyenze ibe luncedo kwiintlobo ngeentlobo zezicelo zokugquma.

Uzinzo lweThermal:

I-polymer ngokuqhelekileyo ibonisa ukuzinza okulungileyo kwe-thermal, igalelo kwi-versatility yayo kwiinkqubo ezahlukeneyo.

3. Ukudibanisa:

Etherification:

I-synthesis ibandakanya i-etherification ye-cellulose kunye ne-propylene oxide ukwazisa amaqela e-hydroxypropyl.

I-methylation elandelayo kunye ne-methyl chloride yongeza amaqela e-methyl kumqolo we-cellulose.

Umgangatho wokutshintshwa unokulawulwa ngexesha lokudibanisa ukufumana iipropati ezifunwayo.

4. Isicelo:

A. Ishishini lamachiza:

Izibophelelo kunye needisintegrants:

Isetyenziswa njengesibophelelo kwimiqulu yethebhulethi ukubopha izithako kunye.

Isebenza njenge-disintegrant ukukhuthaza ukuchithwa kwamacwecwe kwinkqubo yokugaya.

Ukukhutshwa okuzinzileyo:

I-L-HPMC isetyenziswa kwimixube elawulwayo yokukhutshwa, evumela ichiza ukuba likhutshwe kancinci kancinci ekuhambeni kwexesha.

Amalungiselelo asemxholweni:

Ifunyenwe kwi-creams, i-gel kunye ne-ointments, inika i-viscosity kwaye iphucula ukusasazeka kweefomyula.

B. Ishishini lokutya:

Thickener:

Yandisa i-viscosity yokutya kwaye iphucula ukuthungwa kunye ne-mouthfeel.

isizinzi:

Ukwandisa ukuzinza kwe-emulsions kunye nokumiswa.

Ukwenziwa kwefilimu:

Iifilimu ezityiwayo zokupakisha ukutya.

C. Ushishino lokwakha:

Udaka kunye nesamente:

Isetyenziswa njengearhente yokugcina amanzi kwizinto ezisekwe kwisamente.

Ukuphucula ukusebenza kunye nokunamathela kwimiqulu yodaka.

D. Izithambiso:

Iimveliso zokhathalelo lomntu:

Ifunyenwe kwi-creams, i-lotions kunye ne-shampoos ukunceda ukuphucula ukuthungwa kunye nokuzinza.

Isetyenziswe njenge-arhente yokwenza ifilimu kwizinto zokuthambisa.

5. Ukongamela:

Ivunyiwe yi-FDA:

I-L-HPMC ibonwa ngokubanzi njengekhuselekile (GRAS) yi-US Food and Drug Administration (FDA).

Ukuthotyelwa kwemigangatho yolawulo kubalulekile ekusetyenzisweni kwayo kumayeza kunye nokutya.

6. Imingeni kunye nezinto ezilindelekileyo kwixesha elizayo:

Ukonakala kwezinto eziphilayo:

Nangona iipolima ezisekwe kwi-cellulose zithathwa ngokuba zinokubola, ubungakanani be-biodegradation yezinto eziphuma kwi-cellulose ezitshintshiweyo zifuna uphando olongezelelweyo.

Uzinzo:

Ukufunwa okuzinzileyo kwemathiriyeli ekrwada kunye neendlela zokuvelisa ezihambelana nokusingqongileyo ziindawo ekuqhubekeka kujoliswa kuzo.

7. Isiphelo:

I-low-substituted hydroxypropyl methylcellulose ibonisa ubuchule bokuguqulwa kweekhemikhali ekusebenziseni iipropati ze-polymers zendalo. Ukusetyenziswa kwayo okwahlukeneyo kumashishini ahlukeneyo kubalaselisa ukubaluleka kwayo kwimveliso yanamhlanje. Njengoko ukuqhubela phambili kwetekhnoloji kunye nozinzo kuthatha indawo esembindini, uphononongo oluqhubekayo kunye nokuphuculwa kwe-L-HPMC kunye neekhompawundi ezifanayo zinokubumba ikamva lezinto zesayensi kunye nezenzo zeshishini.