Yintoni i-HPMC E3?

I-HPMC E3, okanye i-hydroxypropyl methylcellulose E3, luhlobo lwe-ether ye-cellulose esetyenziswa ngokuqhelekileyo kwishishini lamachiza njenge-binder, i-thickener, kunye ne-arhente yokukhululwa eqhubekayo kwi-tablet kunye ne-capsule formulations. Yipolymer engeyiyo ionic ethathwe kwiselulosi yendalo ngokuguqulwa kweekhemikhali, uluhlu lwe-viscosity ye-HPMC E3 yi-2.4-3.6 mPas.

Kushishino lwamayeza, i-HPMC E3 isoloko isetyenziswa njengenye indlela kwezinye izibophelelo, ezifana nesitatshi okanye igelatin, kuba sisityalo esisekwe kwisityalo, imifuno. Kwakhona iyahambelana kakhulu kunye neentlobo zezithako ezisebenzayo zamachiza (APIs) kunye nabancedisi, okwenza kube yinto edibeneyo kwaye isetyenziswe ngokubanzi kwiindlela ezininzi zokuxutywa kwamayeza.

Enye yeenzuzo eziphambili ze-HPMC E3 kwizicelo zamachiza kukukwazi kwayo ukusebenza njengesibophelelo. Xa isetyenziswa njengesibophelelo, i-HPMC E3 inceda ukubamba isithako esisebenzayo kunye nezinye izinto ezincedisayo kunye, ukwenza ithebhulethi okanye i-capsule. Oku kubalulekile kuba iqinisekisa ukuba ithebhulethi okanye i-capsule igcina imilo yayo kunye nokunyaniseka kuyo yonke inkqubo yokuvelisa kunye nexesha lokugcinwa kunye nokuthutha.

I-HPMC E3 nayo ineempawu ezigqwesileyo zokujiya, eziyenza ibe luncedo njenge-arhente yokuxhoma kwimixube yolwelo. Inceda ukunqanda ukuhlaliswa kwesithako esisebenzayo kunye nezinye iinqununu kwi-liquid, ukuqinisekisa ukuba ukumiswa kuhlala ku-homogeneous kunye neyunifomu kuyo yonke ishelufu yobomi bemveliso.

Esinye isicelo esibalulekileyo se-HPMC E3 kumachiza kukusetyenziswa kwayo njenge-arhente yokukhululwa eqhubekayo. Xa isetyenziswe kwesi sikhundla, i-HPMC E3 inceda ukucotha ukukhutshwa kwesithako esisebenzayo kwithebhulethi okanye i-capsule, evumela ukukhululwa okulawulwayo kunye ngokuthe ngcembe ngokuhamba kwexesha. Oku kubaluleke kakhulu kumayeza afuna ukukhutshwa ngokucothayo nangokucothayo kwixesha elongeziweyo ukuze agcine isiphumo sawo sonyango.

I-HPMC E3 ikwasetyenziswa njenge-arhente yokugquma iipilisi kunye ne-capsules. Xa isetyenziswe kwesi sikhundla, inceda ukukhusela isithako esisebenzayo ekuthotyweni ngokukhanya, ukufuma, kunye nezinye izinto zokusingqongileyo, ukuqinisekisa ukuba iyeza lihlala lisebenza kwaye lizinzile kubomi balo beshelufu. Iingubo ze-HPMC E3 zingasetyenziselwa ukugquma incasa kunye nevumba lesithako esisebenzayo, nto leyo eyenza kube mnandi kakhulu kwizigulana.

Ukongeza ekusebenziseni iipilisi kunye ne-capsules, i-HPMC E3 iphinda isetyenziswe kwezinye iindlela zokuxutywa kwamayeza, njengeekhrimu, iijeli, kunye namafutha okugcoba. Kule miqulu, inceda ukuphucula i-viscosity kunye nokuthungwa kwemveliso, okwenza kube lula ukuyifaka kwesikhumba okanye kwenye indawo echaphazelekayo. I-HPMC E3 iphinda isetyenziswe njenge-gelling agent kwi-topical formulations, inceda ukwenza i-gel-efana ne-consistency enikezela ukukhululwa okuqhubekayo kwesithako esisebenzayo.

Idosi ecetyiswayo ye-HPMC E3 ekuxutyweni kwamachiza iyahluka ngokuxhomekeke kwisicelo esithile kunye neempawu ezifunwayo zemveliso yokugqibela. Ngokuqhelekileyo, i-dosage ye-1% ukuya kwi-5% ye-HPMC E3 ngokusekelwe kubunzima obupheleleyo bokuqulunqwa kunconywa.