Yintoni eyenza i-hypromellose emzimbeni?

IHypromellose, ekwabizwa ngokuba yi-hydroxypropyl methylcellulose (HPMC), yipolymer eyenziweyo evela kwiselulosi. Isetyenziswa ngokuqhelekileyo kumashishini ahlukeneyo, kuquka amayeza, izinto zokuthambisa, kunye neemveliso zokutya. Kwiyeza, i-hypromellose inezicelo ezininzi ngenxa yeempawu zayo ezizodwa.

1. Intshayelelo yeHypromellose:

I-Hypromellose yi-hydrophilic polymer eyenza isisombululo esicacileyo, esibonakalayo xa inyibilika emanzini. Ngokuqhelekileyo isetyenziswe njengesithako esingasebenziyo ekuqulunqweni kwamachiza ukuphucula iimpawu zemveliso ezifana ne-viscosity, ukuzinza, kunye ne-bioavailability. I-Hypromellose isetyenziswa ngokubanzi kwiifom zedosi yomlomo eqinileyo, amalungiselelo e-ophthalmic, kunye ne-topical formulations.

2. Usetyenziso lwezamayeza:

a. IiFom zoMdobo oLuqilima woMlomo:

Kumayeza omlomo, i-hypromellose isebenza ngeenjongo ezahlukeneyo:

I-Binder: Inceda ukubopha izithako ezisebenzayo zamachiza (APIs) kunye nokwenza iipilisi okanye iipilisi.

I-Disintegrant: I-Hypromellose iququzelela ukuhlukana kweepilisi okanye iipilisi kwi-gastrointestinal tract, ukukhuthaza ukukhululwa kweziyobisi kunye nokufunxa.

Ifilimu yangaphambili: Isetyenziselwa ukwenza ifilimu ecekeceke, ekhuselayo yokugquma kwiipilisi ukwenzela ukukhutshwa okulawulwayo okanye ukugquma izinto ezingathandekiyo.

b. Amalungiselelo e-Ophthalmic:

Kwi-eye drops kunye namafutha, i-hypromellose isebenza njenge:

I-Viscosity Modifier: Yonyusa i-viscosity yamathontsi eliso, ibonelela ngexesha elide lokunxibelelana nomphezulu we-ocular kunye nokuphucula ukuhanjiswa kweziyobisi.

I-Lubricant: IHypromellose ithambisa umphezulu weliso, ithomalalisa ukoma kunye nokungonwabi okunxulumene neemeko ezifana nesifo samehlo esomileyo.

c. Uqulunqo lwezihloko:

Kwiimveliso zezihloko ezinjengeekhrimu, iijeli, kunye namafutha, i-hypromellose isebenza ngale ndlela:

I-Gelling Agent: Inceda ukwenza i-gel-like consistency, ukuphucula ukusasazeka kunye nokunamathela kwemveliso kwesikhumba.

I-Moisturizer: I-Hypromellose igcina ukufuma, ihambisa ulusu kwaye ikhusela ukulahleka kwamanzi.

3. Indlela yokwenza:

Indlela yokusebenza yeHypromellose ixhomekeke kwisicelo sayo:

Ulawulo lomlomo: Xa ifakwe, i-hypromellose idumba xa idibana namanzi kwindawo yesisu, ikhuthaza ukuchithwa kunye nokuchithwa kwefom yedosi. Oku kuvumela ukukhululwa okulawulwayo kunye nokufunxa iyeza.

Ukusetyenziswa kwe-Ophthalmic: Kumathontsi esweni, i-hypromellose yonyusa i-viscosity yesisombululo, yandisa ixesha lokunxibelelana kwe-ocular kunye nokuphucula ukufunxwa kweziyobisi. Ikwabonelela ngokuthambisa ukukhulula ukoma kunye nokucaphuka.

I-Topical Application: Njenge-ejenti ye-gelling, i-hypromellose yenza umaleko wokukhusela esikhumbeni, ukuthintela ukulahleka komswakama kunye nokuququzelela ukufunxwa kwezinto ezisebenzayo.

4. Iprofayile yoKhuseleko:

IHypromellose ngokuqhelekileyo ithathwa njengekhuselekile ukuba isetyenziswe kumayeza, izinto zokuthambisa, kunye neemveliso zokutya. Ayinatyhefu, ayicaphukisi, kwaye ayinayo i-allergenic. Nangona kunjalo, abantu abane-hypersensitivity eyaziwayo kwi-cellulose derivatives kufuneka baphephe iimveliso ezine-hypromellose. Ukongeza, amathontsi eliso aqulethe i-hypromellose anokubangela ukufiphala kombono okwethutyana emva kokulawulwa, oko kusombulula ngokukhawuleza.

5. Iimpembelelo ezinokuthi zibe kho:

Ngelixa i-hypromellose inyamezeleka kakuhle ngabantu abaninzi, ezinye iziphumo ezinqabileyo ezinokuthi zenzeke, kubandakanya:

Iimpendulo ze-Aleji: Kubantu abanovakalelo, ukusabela kwe-hypersensitivity efana nokurhawuzelelwa, ukubabomvu, okanye ukudumba kunokuthi kwenzeke xa bekuvezwe kwiimveliso ezine-hypromellose.

Ukucaphuka kwe-Ocular: Amaconsi eliso ane-hypromellose anokubangela ukucaphuka kancinci, ukutshisa, okanye ukubetha xa kufakwe.

Ukuphazamiseka kwesisu: Kwiimeko ezinqabileyo, amayeza omlomo aqukethe i-hypromellose angabangela iimpawu zesisu ezifana ne-nausea, i-bloating, okanye isifo sohudo.

I-Hypromellose yipolymer eguquguqukayo enezicelo ezahlukeneyo zamayeza, kubandakanya iifom zedosi yomlomo eqinileyo, amalungiselelo e-ophthalmic, kunye ne-topical formulations. Iphucula iimpawu zemveliso ezifana ne-viscosity, uzinzo, kunye ne-bioavailability, ukuphucula ukuhanjiswa kweziyobisi kunye nokuthotyelwa kwesigulane. Ngaphandle kokusetyenziswa kwayo ngokubanzi kunye neprofayile yokhuseleko eqhelekileyo, abantu abane-hypersensitivity eyaziwayo kwizinto eziphuma kwi-cellulose kufuneka basebenzise iimveliso ezine-hypromellose ngononophelo. Lilonke, i-hypromellose idlala indima ebalulekileyo kuqulunqo lwangoku lwamayeza, igalelo ekusebenzeni nasekukhuseleni amayeza kunye neemveliso zonyango.