I-Hydroxypropylmethylcellulose (HPMC) i-polymer esebenzayo ephuma kwi-cellulose esetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa. Ikhompawundi idityaniswe ngoluhlu lweekhemikhali zokuguqulwa kweselulosi, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo.
Impahla engekasilwa:
Umthombo: I-Cellulose yeyona nto iphambili ye-HPMC, ininzi ngendalo kwaye ikhutshwe kwizityalo. I-pulp yokhuni kunye ne-cotton linters yimithombo eqhelekileyo ye-cellulose.
Isolation: Inkqubo yokukhutshwa ibandakanya ukudiliza iindonga zeseli yesityalo kunye nokwahlula iifiber ze-cellulose. Iindlela ezahlukeneyo zeekhemikhali kunye nezoomatshini zingasetyenziselwa le njongo.
Ipropylene oxide:
Umthombo: I-Propylene oxide yi-organic compound ephuma kwimithombo yepetrochemical.
Umsebenzi: I-Propylene oxide isetyenziselwa ukwazisa amaqela e-hydroxypropyl kwiimolekyuli ze-cellulose ngexesha lenkqubo yokudibanisa, ukuphucula ukunyibilika kwamanzi kunye nokutshintsha iimpawu ezibonakalayo ze-HPMC ezibangelwayo.
I-Methyl chloride:
Umthombo: I-Methyl chloride yi-chlorinated hydrocarbon enokuthi yenziwe kwi-methanol.
Umsebenzi: I-Methyl chloride isetyenziselwa ukwazisa amaqela e-methyl kwiimolekyuli ze-cellulose, ezinegalelo kwi-hydrophobicity yonke ye-HPMC.
Isodium hydroxide (NaOH):
Umthombo: I-sodium hydroxide, eyaziwa ngokuba yi-caustic soda, isiseko esomeleleyo kwaye iyafumaneka kurhwebo.
Umsebenzi: I-NaOH isetyenziselwa ukuvuselela ukusabela kunye nokulungelelanisa ixabiso le-pH lomxube wokuphendula ngexesha lenkqubo yokudibanisa.
Udibaniso:
Udibaniso lwe-HPMC lubandakanya amanyathelo aliqela, kwaye inkqubo yokusabela inokushwankathelwa ngolu hlobo lulandelayo:
Ialkalizing:
I-cellulose iphathwa nge-sodium hydroxide ukuvelisa i-alkaline cellulose.
I-Alkali cellulose iphinda ithathwe ngepropylene oxide ukwazisa amaqela e-hydroxypropyl.
I-Methylation:
Iselulosi ye-Hydroxypropylated iphinda iphinde isetyenziswe nge-methyl chloride ukwazisa amaqela e-methyl.
Eli nyathelo linika i-polymer uzinzo olongezelelweyo kunye ne-hydrophobicity.
Ukulungiswa phakathi kunye nokucoca:
Umxube wokusabela wawungathintelwanga ukususa isiseko esingaphezulu.
Ukuhluzwa kwenziwa ukwahlula i-cellulose elungisiweyo.
Ukuhlamba kunye nokomisa:
Imveliso eyahluliweyo iyahlanjwa ize yomiswe ukuze ifumane i-hydroxypropyl methylcellulose kwipowder okanye i-granular form.
Ukunyibilika kophawu lwe-HPMC:
I-HPMC i-soluble emanzini kwaye ukunyibilika kwayo kunokulungelelaniswa ngokwenqanaba lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl.
Isakhono sokwenza ifilimu:
I-HPMC yenza iifilimu eziguquguqukayo, ezicacileyo ezifanelekileyo kwizicelo kumashishini amayeza kunye nokutya.
Viscosity:
I-viscosity yesisombululo se-HPMC inokulawulwa kwaye isoloko isetyenziswa njenge-thickener kunye ne-gelling agent kwi-formula ezahlukeneyo.
I-Thermal Gelation:
Amabanga athile e-HPMC abonisa iipropati ze-thermogelling, ezenza ijeli xa ishushu kwaye ibuyela kwisisombululo xa ipholile.
Umsebenzi womphezulu:
I-HPMC ingasetyenziswa njenge-surfactant, kwaye umsebenzi wayo womphezulu uchatshazelwa ngumgangatho wokutshintshwa.
Amachiza asetyenzisiweyo e-HPMC:
I-HPMC isetyenziswa ngokubanzi kwimixube yamachiza njengezibophelelo, ii-disintegrants, kunye nee-arhente zokukhululwa ezilawulwayo kwiipilisi kunye nee-capsules.
Ishishini lokwakha:
Kwicandelo lolwakhiwo, i-HPMC isetyenziswa njengento etyebisayo kwiimveliso ezisekwe kwisamente ezifana nodaka kunye nokunamatheliswa kweethayile.
ishishini lokutya:
I-HPMC isetyenziswa kushishino lokutya njengento etyebisayo, i-emulsifier kunye ne-stabilizer kwiimveliso ezahlukeneyo, kubandakanya iisosi, izimuncumuncu kunye ne-ayisikrimu.
Iimveliso zokhathalelo lomntu:
Kwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu, i-HPMC isetyenziswa kwimixube efana nekhrimu, izinto zokuthambisa kunye neshampu ngenxa yokujiya nokuzinza kwayo.
Iipeyinti kunye neeNqaku:
I-HPMC yongezwa kwiipeyinti kunye neengubo zokulawula i-viscosity, ukuphucula iipropati zesicelo kunye nokuphucula iipropati zokwenza ifilimu.
Izisombululo zeOphthalmic:
I-HPMC isetyenziswa kumathontsi eliso kunye neenyembezi ezenziweyo ngenxa ye-biocompatibility yayo kunye neempawu ze-mucoadhesive.
ukuququmbela:
IHydroxypropylmethylcellulose (HPMC) yipolymer ephawulekayo edityaniswe kwi cellulose yomthombo ohlaziyekayo. Iipropati zayo ezininzi ezisebenzayo kunye noluhlu olubanzi lwezicelo zenza ukuba ibe yinto ephambili kumashishini ahlukeneyo, ukusuka kumachiza ukuya kulwakhiwo kunye nokutya. Ngokukhetha ngononophelo izinto ezikrwada kunye nolawulo lweeparamitha ze-synthesis, ii-HPMC ezineempawu ezilungiselelweyo zinokuveliswa ukuhlangabezana neemfuno ezithile zezicelo ezahlukeneyo. Njengoko itekhnoloji kunye neemfuno ziqhubeka nokuvela, i-HPMC kusenokwenzeka ukuba ihlale ingumdlali ophambili ekuveliseni izinto ezintsha kunye nophuhliso oluzinzileyo lwemveliso kuwo wonke amashishini.
Ixesha lokuposa: Dec-18-2023