I-Hydroxypropyl methylcellulose (HPMC) yi-ether ye-cellulose ebalulekileyo, esetyenziswa ngokubanzi ekwakheni, amayeza, ukutya, iikhemikhali zemihla ngemihla kunye nezinye iindawo. I-HPMC yipolymer enyibilikayo emanzini efunyenwe ngokuguqulwa kweekhemikhali zeselulosi yendalo, eneempawu ezininzi ezibalaseleyo zomzimba kunye neekhemikhali.
1. Iimpawu ezibonakalayo
Inkangeleko kunye ne-morphology: I-HPMC idla ngokuba ngumgubo omhlophe okanye otyheli kancinane, ayinavumba, ayinancasa, kwaye inomanzi. Inokwenza ifilimu efanayo okanye i-gel ngokusebenzisa iindlela ezahlukeneyo zokucubungula, okwenza ukuba isebenze kakuhle kwizicelo ezininzi.
Ukunyibilika: I-HPMC inyibilika ngokulula emanzini abandayo, kodwa ayinyibiliki emanzini ashushu. Xa iqondo lobushushu lifikelela kwinqanaba elithile (ngokuqhelekileyo 60-90℃), HPMC ilahlekelwa ukunyibilika emanzini kwaye yenza ijeli. Le propati yenza ukuba ibonelele ngesiphumo sokujiya xa ishushu, kwaye ibuyele kwimeko yesisombululo samanzi esicacileyo emva kokupholisa. Ukongeza, i-HPMC inyibilika ngokuyinxenye kwizinyibilikisi eziphilayo ezifana ne-ethanol.
I-Viscosity: I-viscosity yesisombululo se-HPMC yenye yezinto zayo ezibalulekileyo zomzimba. I-viscosity ixhomekeke kubunzima bayo be-molecular kunye nokugxininiswa kwesisombululo. Ngokuqhelekileyo, ubukhulu be-molecular weight, buphezulu i-viscosity yesisombululo. I-HPMC inoluhlu olubanzi lwe-viscosity kwaye inokulungelelaniswa ngokweemfuno ezithile zesicelo, eyenza isetyenziswe ngokubanzi kulwakhiwo, amayeza, imichiza yemihla ngemihla kunye namanye amashishini.
Ipropati yokwenza ifilim: I-HPMC inepropathi egqwesileyo yokwenza ifilim. Inokwenza ifilimu ecacileyo kunye nenzima emva kokunyibilika emanzini okanye kwi-solvents eziphilayo. Ifilimu ine-oyile efanelekileyo kunye nokuchasana kwamafutha, ngoko ke isetyenziswa rhoqo njengento yokugqoka kwiindawo zokutya kunye neyeza. Ukongeza, ifilimu ye-HPMC inokumelana nokufuma okuhle kwaye inokukhusela ngokufanelekileyo izinto zangaphakathi kubumanzi.
Uzinzo lwe-Thermal: I-HPMC inozinzo oluhle lwe-thermal. Nangona ilahlekelwa yi-solubility kwaye yenza ijeli kwiqondo lokushisa eliphezulu, inozinzo oluhle kakhulu lwe-thermal kwindawo eyomileyo kwaye inokumelana nokushisa okuphezulu ngaphandle kokubola. Olu phawu lunika inzuzo ekusebenzeni okuphezulu kobushushu.
2. Iimpawu zeMichiza
Uzinzo kwimichiza: I-HPMC inozinzo oluhle lweekhemikhali kwiqondo lobushushu begumbi kwaye izinzile ngakumbi kwiiasidi, iialkali kunye neetyuwa. Ngoko ke, kwiinkqubo ezininzi zeekhemikhali okanye iinkqubo zokuqulunqa, i-HPMC ingabakho njenge-stabilizer kwaye akukho lula ukusabela kwimichiza kunye nezinye izithako.
Ukuzinza kwe-pH: I-HPMC ihlala izinzile kuluhlu lwe-pH 2-12, eyenza ukuba isebenziseke kwiindawo ezahlukeneyo ze-pH. I-HPMC ayiyi kutyhutyha i-hydrolysis okanye ukuthotywa phantsi kweemeko ze-acidic okanye i-alkaline, eyenza isetyenziswe ngokubanzi kukutya, amayeza, kunye nezithambiso.
I-Biocompatibility kunye ne-non-toxicity: I-HPMC ine-biocompatibility efanelekileyo kwaye inokusetyenziswa ngokukhuselekileyo kumayeza, ukutya kunye nezinye iindawo ezineemfuno eziphezulu kakhulu kwimpilo yabantu. I-HPMC ayinayo ityhefu kwaye ayicaphukisi, kwaye ayiyi kuchithwa kwiimolekyuli ezincinci ngee-enzymes zokugaya emzimbeni, ngoko ingasetyenziswa njenge-arhente yokukhululwa elawulwayo yamachiza okanye i-thickener yokutya.
Ukuguqulwa kwemichiza: I-HPMC iqulethe inani elikhulu lamaqela e-hydroxyl kwisakhiwo sayo se-molecular, enokuphuculwa okanye inikwe iipropati ezintsha ngokuguqulwa okungaphezulu kweekhemikhali. Ngokomzekelo, ngokusabela nge-aldehydes okanye i-organic acids, i-HPMC inokulungiselela iimveliso ezinokumelana nokushisa okuphezulu okanye ukuxhathisa kwamanzi. Ukongeza, i-HPMC inokudityaniswa nezinye iipholima okanye izongezo ukwenza imathiriyeli edibeneyo ukuhlangabezana neemfuno zezicelo ezithile.
I-adsorption yokufuma: I-HPMC ine-hygroscopicity eyomeleleyo kwaye inokufunxa ukufuma emoyeni. Le propati ivumela i-HPMC ukuba ijiye kwaye ilawule ukufuma kwemveliso kwezinye izicelo. Nangona kunjalo, kwezinye iimeko, ukufunxa ngokugqithisileyo kokufuma kunokuchaphazela uzinzo lwemveliso, ngoko ke isiphumo sokufuma kwe-ambient ekusebenzeni kwe-HPMC kufuneka kuqwalaselwe xa usebenzisa.
3. Iinkalo zesicelo kunye neenzuzo
Ngenxa yeempawu zayo ezizodwa kunye neekhemikhali, i-HPMC inoluhlu olubanzi lwexabiso lesicelo kwiinkalo ezininzi. Ngokomzekelo, kwintsimi yokwakha, i-HPMC isetyenziswe njenge-thickener kunye ne-ejenti yokugcina amanzi kwizinto ezisekelwe kwi-samente ukuphucula ukwakhiwa kunye nokuqina kwezinto zokwakha; kwintsimi yamachiza, i-HPMC isetyenziswa rhoqo njenge-adhesive tablet, i-ejenti yokukhululwa elawulwayo, kunye ne-capsule coating material; kwindawo yokutya, isetyenziswa njenge-thickener, emulsifier, kunye ne-stabilizer ukuphucula incasa kunye nokuthungwa kokutya.
IHydroxypropyl methylcellulose idlala indima engenakuthathelwa indawo kumashishini amaninzi ngenxa yeempawu zayo ezibalaseleyo zomzimba kunye neekhemikhali. Ukusebenza kwayo okugqwesileyo kwi-solubility yamanzi, iipropati zokwenza ifilimu, ukuzinza kweekhemikhali, njl njl. kwenza i-HPMC ibe yinto efunekayo kwizinto ezininzi ezisebenzayo kwishishini kunye nobomi bemihla ngemihla.
Ixesha lokuposa: Aug-22-2024