I-Hydroxypropyl Methylcellulose (HPMC) yi-ether ye-cellulose e-nonionic esetyenziswa kakhulu kumashishini afana nokwakhiwa, amayeza, ukutya, izimonyo kunye neengubo. Ukuguquguquka kwayo kuvela kwiimpawu zayo ezizodwa ze-physicochemical ezifana nokuqina, ukudibanisa, ukwenza ifilimu, ukugcinwa kwamanzi kunye nokuthambisa. Amabakala ahlukeneyo e-HPMC ahlelwa ngokukodwa ngokweqondo labo lokutshintshela (DS) kunye nomxholo we-methoxy kunye ne-hydroxypropyl, ngaphezu kwe-viscosity yabo, ubungakanani be-particle kunye nococeko. La mabanga ahlukeneyo e-HPMC aneempawu ezahlukeneyo zesicelo kunye nokusetyenziswa.
1. Umxholo we-Methoxy kunye nomxholo we-hydroxypropyl
I-methoxy kunye ne-hydroxypropyl substituent content ye-HPMC yinto ephambili emisela ukusebenza kwayo. Ngokuqhelekileyo, umxholo we-methoxy we-HPMC uphakathi kwe-19% kunye ne-30%, kwaye umxholo we-hydroxypropyl uphakathi kwe-4% kunye ne-12%. I-HPMC enomxholo ophezulu we-methoxy ngokubanzi ine-solubility engcono kunye neepropati zokwenza ifilimu, ngelixa i-HPMC enomxholo ophezulu we-hydroxypropyl inomgangatho ongcono kunye nokugcinwa kwamanzi. Ezi parameters zichaphazela ngqo ukusetyenziswa HPMC. Ngokomzekelo, kwishishini lokwakha, umxholo ophezulu we-methoxy unceda ukuphucula ukugcinwa kwamanzi kunye nokusebenza kokwakhiwa kodaka; kwintsimi yamachiza, umxholo ophezulu we-hydroxypropyl unceda ukuphucula ukunamathela kunye nokukhululwa kweempawu zamachiza.
2. Ibakala leViscosity
I-HPMC inokohlulwa ibe yi-viscosity ephantsi, i-viscosity ephakathi kunye namabakala aphezulu e-viscosity ngokwe-viscosity yesisombululo sayo. I-Viscosity yipropati ebalulekileyo ebonakalayo ye-HPMC, ngokuqhelekileyo ilinganiswa ne-viscosity ebonakalayo yesisombululo se-2% kwimizuzwana ye-milliPascal (mPa.s).
I-HPMC ye-viscosity ephantsi (efana ne-5 mPa ukuya kwi-100 mPa.s): Olu hlobo lwe-HPMC ludla ngokusetyenziswa kwizicelo ezifuna imiphumo ephantsi yokuqina, njengamathontsi esweni, izitshizi kunye nezithambiso. Kwezi zicelo, i-viscosity ephantsi ye-HPMC inokubonelela nge-fluidity elungileyo kunye nokusabalalisa okufanayo.
Medium viscosity HPMC (umz 400 mPa.s ukuya 2000 mPa.s): Medium viscosity HPMC iqhele ukusetyenziswa kwizinto zokwakha, emulsions kunye nokuncamathelisa ukubonelela imiphumo ephakathi ukujiya, leyo inokulinganisa ukusebenza kolwakhiwo kunye namandla emzimbeni wemveliso yokugqibela.
High viscosity HPMC (umz. 4000 mPa. 200,000 mPa.s): High viscosity HPMC isetyenziswa ikakhulu kwizicelo ezifuna ukujiya okubalulekileyo, ezifana nodaka, putty, izinto zokuncamathelisa iithayile kunye nokugquma. Kwezi mveliso, i-viscosity ephezulu ye-HPMC inceda ekuphuculeni ukugcinwa kwamanzi, ukuchasana nokuqina kunye namandla okudibanisa.
3. Ubungakanani besuntswana
Ubungakanani besuntswana le-HPMC nalo lichaphazela isiphumo sesicelo sayo. Ngokubanzi, i-HPMC inokohlulwa ibe ngamasuntswana arhabaxa kunye namasuntswana amahle. Isuntswana elirhabaxa HPMC idla ngokusetyenziswa kwizicelo ezifuna ukuchithwa ngokukhawuleza okanye ukusasazwa, ngelixa i-particle ecolekileyo i-HPMC ifanelekile kwiimveliso ezineemfuno eziphezulu zokubonakala okanye zifuna ukuhanjiswa okufanayo.
I-HPMC ene-coarse-grained: I-HPMC enamaqhekeza amakhulu inesantya esikhawulezayo sokuchithwa kwi-dry-mixed mortar kunye nezinye iindawo, kwaye inokukhawuleza ukwenza isisombululo esifanayo, ngaloo ndlela iphucula ukusebenza kakuhle kwemveliso.
Fine-grained HPMC: Fine-grained HPMC isetyenziswa kakhulu kumashishini afana neepeyinti, iingubo kunye nezinto zokuthambisa. Inokwenza uluhlu lwefilimu efanayo ngakumbi ngexesha lenkqubo yesicelo, ukuphucula i-gloss kunye nokuvakalelwa kwemveliso.
4. Ubunyulu kunye namabakala akhethekileyo
Ngokweemfuno ezahlukeneyo zesicelo, i-HPMC inokucocwa ngakumbi okanye isebenze. I-HPMC enobunyulu obuphezulu idla ngokusetyenziswa kumashishini amayeza kunye nokutya ukuqinisekisa ukhuseleko kunye nokuhambelana kwezinto eziphilayo kwimveliso. Ukongeza, kukho ezinye ii-HPMC ezinemisebenzi ekhethekileyo, efana ne-HPMC edibeneyo, i-HPMC ephathwayo, njl.
Ibakala le-Pharmaceutical HPMC: Ibakala le-Pharmaceutical HPMC linobunyulu obuphezulu kwaye lifanelekile kwiipilisi, iipilisi kunye namalungiselelo okukhululwa okuqhubekayo, anokuphucula kakhulu izinga lokukhululwa kunye nokuzinza kwamachiza.
Ibakala lokutya HPMC: Ibakala lokutya HPMC isetyenziswa njenge thickener ukutya, stabilizer kunye emulsifier ukuqinisekisa ukhuseleko kunye incasa yokutya.
I-HPMC ye-Industrial grade: I-HPMC esetyenziswa kulwakhiwo, i-coatings kunye nezinye iindawo zinokuqulatha ukungcola okuncinci, kodwa kunokubonelela ngoqoqosho oluphezulu kunye nokusebenza kakuhle.
5. Iinkalo zesicelo kunye nokukhetha
Amabanga ahlukeneyo e-HPMC asetyenziswa ngokubanzi kulwakhiwo, amayeza, ukutya, izithambiso kunye nezinye iinkalo. Xa ukhetha ibakala elifanelekileyo le-HPMC, izinto ezifana ne-viscosity, umxholo we-substituent, ubukhulu be-particle kunye nococeko kufuneka ziqwalaselwe ngokweemfuno zezicelo ezithile.
Intsimi yokwakha: Kwizinto zokwakha, i-HPMC isetyenziswa ikakhulu njengento yokutyebisa, yokugcina amanzi kunye nesibophelelo. Ukusetyenziswa okufana nodaka olomileyo kunye ne-adhesives tile, kubalulekile ukukhetha i-HPMC kunye ne-viscosity efanelekileyo kunye nokugcinwa kwamanzi.
Intsimi yamachiza: Kumalungiselelo amayeza, i-HPMC isetyenziswa njengempahla ye-capsule shell, i-tablet kunye ne-adhesive. Kuyimfuneko ukuba ukhethe amabanga e-HPMC ngokusebenza okufanelekileyo kokukhutshwa kwechiza kunye ne-biocompatibility.
Ukutya kunye nezithambiso: Kwishishini lokutya kunye nezithambiso, i-HPMC isetyenziswa njenge-thickener kunye ne-stabilizer, kwaye ukucoceka kwayo kunye nokhuseleko zizinto eziphambili zokuqwalaselwa.
Amabanga ahlukeneyo eHydroxypropyl Methylcellulose (HPMC) aneenzuzo zawo kunye nemida esebenzayo kwizicelo. Ukuqonda kunye nokukhetha ibakala elifanelekileyo le-HPMC kunokuphucula ngokufanelekileyo ukusebenza kunye nomgangatho wemveliso kunye nokuhlangabezana neemfuno zemveliso eyahlukeneyo yamashishini kunye nabathengi.
Ixesha lokuposa: Aug-21-2024