Zeziphi iimpawu ze-HPMC?

I-Hydroxypropyl Methylcellulose (HPMC) yinto ebalulekileyo ye-cellulose derivative enoluhlu olubanzi lwezicelo kumashishini amaninzi. Ineempawu ezibalaseleyo zomzimba kunye neekhemikhali, ubuthi obuphantsi, kunye nobuhlobo bendalo.

1. Iimpawu ezisisiseko ze-HPMC

Ubume bemichiza kunye neempawu ezibonakalayo

I-HPMC yi-ether ye-cellulose engeyo-ionic efunyenwe ngokuguqulwa kweekhemikhali zeselulosi yendalo. Ubume bayo obusisiseko bubandakanya iiyunithi ze-glucose, ezenziwe ngokutshintshela amanye amaqela e-hydroxyl kunye namaqela e-hydroxypropyl kunye ne-methyl. Ubume bayo bomzimba ubukhulu becala bumhlophe okanye bumthubi kancinci, obunyibilika ngokulula kumanzi abandayo kunye nashushu ukwenza isisombululo se-viscous esicacileyo okanye esine-turbid.

Ubunzima be-molecular: I-HPMC inoluhlu olubanzi lwee-molecular weights, ukusuka kwi-molecular weight low (efana ne-10,000 Da) ukuya kwisisindo esiphezulu se-molecular (njenge-150,000 Da), kunye neempawu zayo kunye nokusetyenziswa kwazo zitshintsha ngokufanelekileyo.

Ukunyibilika: I-HPMC yenza isisombululo se-colloidal kumanzi abandayo, kodwa ayinyibiliki kwezinye izinyibilikisi ze-organic, kwaye inokunyibilika okulungileyo kunye nokuzinza.

I-Viscosity: I-Viscosity yipropati ebalulekileyo ye-HPMC, echaphazelekayo ubunzima be-molecular kunye nohlobo kunye nenani lababambeli. High-viscosity HPMC idla ngokusetyenziswa njenge ngqindilili kunye nokuzinzisa, lo gama viscosity low-viscosity HPMC isetyenziselwa ukwenza ifilim kunye nemisebenzi bonding.

Uzinzo lwekhemikhali

I-HPMC inozinzo oluphezulu lweekhemikhali, inokuxhathisa ukhukuliseko lweeasidi, iialkali kunye nezinyibilikisi eziqhelekileyo eziphilayo, kwaye akukho lula ukubola okanye ukuthotywa. Oku kuvumela ukuba igcine imisebenzi yayo kwiindawo ezahlukeneyo eziyinkimbinkimbi kwaye ifanelekile kuluhlu olubanzi lwezicelo zoshishino.

Biocompatibility

Ekubeni i-HPMC ithathwe kwi-cellulose yendalo kwaye iguqulwe ngokuphakathi, i-biocompatibility elungileyo kunye netyhefu ephantsi. Ngoko ke, isoloko isetyenziselwa ukutya, amayeza kunye nezithambiso, ukuhlangabezana neemfuno zokhuseleko.

2. Ukulungiselela indlela ye-HPMC

Ukulungiswa kwe-HPMC kuhlala kuhlulwe ngokwamanyathelo amathathu:

Unyango lwe-alkali: i-cellulose yendalo iphathwa ngesisombululo se-alkali (ngokuqhelekileyo i-sodium hydroxide) ukuyidumba kunye nokwandisa ukusebenza kwayo kwakhona.

I-Etherification reaction: Phantsi kweemeko ze-alkaline, i-cellulose ifumana i-etherification reaction kunye ne-methyl chloride kunye ne-propylene oxide, ukwazisa amaqela e-methyl kunye ne-hydroxypropyl ukwenza i-hydroxypropyl methylcellulose.

Ukucocwa: Iimveliso ze-reaction kunye nee-reagents ezishiyekileyo zisuswa ngokuhlamba, ukuhluza kunye nokomisa ukufumana i-HPMC ecocekileyo.

Ngokulawula iimeko zokusabela (ezifana nobushushu, ixesha, umlinganiselo we-reagent, njl.njl.), iqondo lokutshintshela kunye nobunzima bemolekyuli ye-HPMC inokuhlengahlengiswa ukufumana iimveliso ezineempawu ezahlukeneyo.

3. Iinkalo zezicelo ze-HPMC

Izinto zokwakha

Kwishishini lokwakha, i-HPMC isetyenziswa ngokubanzi kudaka lwesamente, iimveliso zegypsum, iingubo, njl njl. Imisebenzi yayo ephambili ibandakanya:

Ukutyeba kunye nokugcinwa kwamanzi: Kwi-mortar kunye ne-coating, i-HPMC inokunyusa i-viscosity kunye nokuphucula ukusebenza kolwakhiwo, ngelixa ibonelela ngesiphumo esihle sokugcinwa kwamanzi kunye nokuthintela ukuqhekeka kwe-shrinkage.

Ukuphucula ukubambelela: Ukomeleza ukubambelela phakathi kodaka kunye ne-substrate kunye nokuphucula umgangatho wokwakha.

Ukuphucula izakhiwo zokwakha: Ukwenza ukwakhiwa kodaka kunye nokugquma kube lula, ukwandisa ixesha elivulekileyo kunye nokuphucula ukugudiswa komhlaba.

Ishishini lamachiza

Ukusetyenziswa kwe-HPMC kwishishini lamachiza kubonakala ikakhulu kumalungiselelo eziyobisi, ngakumbi iipilisi zomlomo kunye neepilisi:

Izinto zokukhululwa ezilawulwayo: I-HPMC isoloko isetyenziselwa ukulungiselela iipilisi zokukhululwa ezilawulwayo, kwaye ukukhutshwa okucothayo kwamachiza kufezekiswa ngokulungelelanisa izinga lokuchithwa.

Izibophelelo zethebhulethi: Kwimveliso yethebhulethi, i-HPMC ingasetyenziswa njengesibophelelo ukubonelela ngobulukhuni obufanelekileyo bethebhulethi kunye nexesha lokuqhekeka.

Ukugquma ifilimu: isetyenziswa njengezinto zokugquma iipilisi zokuthintela i-oxidation kunye nokukhukuliseka kokufuma kweziyobisi kunye nokuphucula ukuzinza kunye nenkangeleko yeziyobisi.

Ishishini lokutya

I-HPMC isetyenziswa njengesongezo sokutya kwishishini lokutya, idlala indima ye-thickener, emulsifier, stabilizer, njl.

I-Thickener: isetyenziswa kwiimveliso zobisi, iisosi, njl.njl. ukunika ukuthungwa okufanelekileyo kunye nencasa.

I-Emulsifier: kwiziphuzo kunye ne-ayisikrimu, inceda ukwenza inkqubo ye-emulsified ezinzileyo.

Ifilimu yangaphambili: kwiilekese kunye neekeyiki, i-HPMC isetyenziselwa ukugquma kunye nokuqaqambisa ukuphucula imbonakalo kunye nokuthungwa kokutya.

Izithambiso

Kwizinto zokuthambisa, i-HPMC isetyenziselwa ukulungisa i-emulsions, iikhrimu, iijeli, njl.

Ukuqina kunye nokuzinzisa: kwii-cosmetics, i-HPMC ibonelela nge-viscosity efanelekileyo kunye nokuzinza, iphucula ukuthungwa kunye nokusabalalisa.

I-Moisturizing: inokwenza i-moisturizing layer kwi-skin surface ukwandisa umphumo wokunyusa wemveliso.

Imichiza yemihla ngemihla

I-HPMC ikwasetyenziswa kwiimveliso zemichiza yemihla ngemihla, njengezokucoca, iimveliso zokhathalelo lomntu, njl.

I-Thickener: kwii-detergents, inyusa i-viscosity yemveliso ukuthintela ukuhluma.

I-arhente yokuxhoma: isetyenziswe kwinkqubo yokunqunyanyiswa ukubonelela ngokuzinza okulungileyo.

4. Izinto eziluncedo kunye nemingeni ye-HPMC

Iingenelo

I-Versatility: I-HPMC inemisebenzi emininzi kwaye inokudlala iindima ezahlukeneyo kwiinkalo ezahlukeneyo, ezinjengokuqina, ukugcinwa kwamanzi, ukuzinzisa, njl.

I-Biocompatibility: Ubuthi obuphantsi kunye ne-biocompatibility efanelekileyo yenza ukuba ilungele ukusetyenziswa kukutya kunye namayeza.

Ihambelana nendalo: Iphuma kwiselulosi yendalo, iyabola kwaye ihambelana nokusingqongileyo.

Imingeni

Iindleko: Xa kuthelekiswa nezinye izinto ezenziweyo zepolymer, i-HPMC inexabiso eliphezulu, elinokuthi linciphise ukusetyenziswa kwayo ngokubanzi kwizicelo ezithile.

Inkqubo yokuvelisa: Inkqubo yokulungiselela ibandakanya ukuphendulwa kweekhemikhali eziyinkimbinkimbi kunye namanyathelo okucoca, ekufuneka ilawulwe ngokungqongqo ukuqinisekisa umgangatho wemveliso.

5. Amathemba ekamva

Ngokuqhubela phambili kwesayensi kunye nobuchwepheshe, amathuba okusetyenziswa kwe-HPMC abanzi kakhulu. Izalathiso zophando lwexesha elizayo zinokubandakanya:

Uphuhliso lwe-HPMC elungisiweyo: Ngokuguqulwa kweekhemikhali kunye nobuchwepheshe obudibeneyo, izinto eziphuma kwi-HPMC ezinemisebenzi ethile ziyaphuhliswa ukuhlangabezana neemfuno ezithile zesicelo.

Inkqubo yamalungiselelo ohlaza: Phanda ngakumbi ngeenkqubo zolungiselelo ezinobungani nokusingqongileyo ukuze kuncitshiswe iindleko zemveliso kunye nomthwalo wokusingqongileyo.

Imimandla emitsha yesicelo: Phonononga ukusetyenziswa kwe-HPMC kwiinkalo ezivelayo, ezifana ne-biomaterials, ukupakishwa okunokonakala, njl.

Njengoko i-cellulose derivative ebalulekileyo, i-hydroxypropyl methylcellulose (HPMC) ineempawu ezibalaseleyo zomzimba kunye neekhemikhali, iindawo ezahlukeneyo zokusetyenziswa kunye nokuhambelana kakuhle kwe-biocompatibility. Kuphuhliso lwexesha elizayo, ngokusungula izinto ezintsha zetekhnoloji kunye nokwandiswa kwesicelo, i-HPMC kulindeleke ukuba idlale iingenelo zayo ezizodwa kwiinkalo ezininzi kwaye ibonelele ngempembelelo entsha kuphuhliso lwemizi-mveliso.