I-Hydroxypropyl methylcellulose (HPMC), i-cellulose ether derivative, isetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo eziphawulekayo zokugcina amanzi.Ezi zakhiwo zibonelela ngoluhlu lweenzuzo kwizicelo ezahlukeneyo, ngakumbi kulwakhiwo, amayeza, iimveliso zokhathalelo lomntu, kunye namashishini okutya.
1. Ushishino loKwakha
a.Ukomelezwa kokuSebenza kunye nokungaguquguquki
I-HPMC iqhele ukusetyenziswa kwizinto zokwakha ezinje ngodaka, iiplasta, kunye neemveliso ezisekwe kwisamente.Ukukwazi kwayo ukugcina amanzi kuqinisekisa ukuba umxube uhlala usebenza ixesha elide.Oku kubalulekile ngexesha lokufaka isicelo, njengoko kuvumela abasebenzi ukuba bafezekiseke kwaye bagqibe ngaphandle kokuba umxube wome ngokukhawuleza.
b.Ukuphuculwa kokuncamathela kunye nokuqina kweBond
Kwii-adhesives ze-tile kunye ne-plasters, i-HPMC inceda ukugcina umgangatho womswakama owaneleyo, oyimfuneko kwi-hydration efanelekileyo ye-samente kunye nezinye ii-agent ezibophayo.Oku kukhokelela ekuphuculeni ukubambelela kunye nokuqina kwebhondi phakathi kwe-substrate kunye nesixhobo esisetyenzisiweyo, ukunciphisa amathuba okuqhekeka kunye nokudibanisa ngokuhamba kwexesha.
c.Inkqubo Yokunyanga Eyongeziweyo
Ukunyangwa ngokufanelekileyo kwezinto ezisekelwe kwisamente kufuna ukufuma okwaneleyo.Iipropati zokugcina amanzi ze-HPMC zinceda ekugcineni amanqanaba okufuma ayimfuneko ngexesha lenkqubo yokunyanga, okukhokelela kwiimveliso zokuphela eziqinileyo nezizinzileyo.Oku kunenzuzo ngakumbi kwimozulu eshushu kunye neyomileyo apho ukuguquka kwamanzi ngokukhawuleza kunokuphazamisa ingqibelelo yolwakhiwo.
2. Ishishini lezamayeza
a.Ukukhutshwa okuLawulwayo kweZithako eziSebenzayo
Ekuqulunqweni kwamachiza, ngokukodwa kwiipilisi ezilawulwayo, i-HPMC isetyenziswa njenge-agent-matrix-forming agent.Ukukwazi kwayo ukugcina amanzi kunceda ekwenzeni i-gel layer ejikeleze ithebhulethi xa ifakwe, elawula ukukhutshwa kwezithako ezisebenzayo.Oku kuqinisekisa umphumo wonyango ohambelanayo kunye nokuphucula ukuthotyelwa kwesigulane ngokunciphisa ukuphindaphinda kwe-dosing.
b.Uzinzo olongeziweyo kunye noBomi beShelf
Iipropati zokugcina amanzi ze-HPMC zinegalelo kuzinzo lweemveliso zoxubo-mayeza ngokugcina umlinganiselo ofanelekileyo wokufuma.Oku kuthintela ukuthotywa kwezithako ezisebenzayo zokufuma kunye nezincedisi, ngaloo ndlela zandisa ubomi beshelufu yeemveliso.
c.Ukuphuculwa kwe-Bioavailability
Kumachiza athile, ugcino lwamanzi lweempawu ze-HPMC zinokuphucula ukufumaneka kwe-bioavailability.Ngokugcina indawo efumileyo, i-HPMC iququzelela ukunyibilika ngcono kwamachiza anyibilikayo anganyibiliki kakuhle emanzini, iqinisekisa ukufunxwa okusebenzayo ngakumbi kwindlela yesisu.
3. Iimveliso zoNonophelo lomntu
a.Ubume obuphuculweyo kunye nokuhambelana
Kwiimveliso zokhathalelo lomntu ezifana nezinto zokuthambisa, iikhrimu, kunye neshampu, i-HPMC isebenza njenge-arhente etyebisayo nezinzisayo.Ukukwazi kwayo ukugcina amanzi kuqinisekisa ukuba ezi mveliso zigcina ukuthungwa okuhambelanayo kunye ne-viscosity, ukuphucula amava omsebenzisi.Oku kubaluleke kakhulu kwiimveliso ezenzelwe ukubonelela nge-hydration kunye ne-moisturization.
b.Ukufuma okongeziweyo
I-HPMC inceda ukwenza umqobo wokukhusela eluswini okanye iinwele, ukunciphisa ilahleko yamanzi kunye nokubonelela ngokufuma ixesha elide.Oku kunenzuzo kwiimveliso ezijoliswe ekuphatheni iimeko zesikhumba esomileyo okanye kwiindlela zokunakekelwa kweenwele ezijoliswe ekukhuseleni ukoma kunye nokuqina.
c.Ukuzinza kweEmulsions
Kwiimveliso ze-emulsified, ezifana ne-creams kunye ne-lotions, i-HPMC izinza i-emulsion ngokugcina amanzi ngaphakathi kwesigaba esiqhubekayo.Oku kuthintela ukuhlukana kwezigaba zeoli kunye namanzi, ukuqinisekisa imveliso ezinzileyo kunye ne-homogenous kuyo yonke ishelufu yayo.
4. Ishishini lokutya
a.Ukuphuculwa kokuThungwa kunye neMouthfeel
Kwishishini lokutya, i-HPMC isetyenziswa njengesongezo sokutya ukuphucula ukuthungwa kunye nokuvakala komlomo.Iipropati zayo zokugcina amanzi zinceda ekugcineni ukufuma kwezinto ezibhakiweyo, ii-noodles, kunye nokunye ukutya okucutshungulwayo, okukhokelela ekuthungeni okuthambileyo kunye nokukhangayo.
b.Ubomi beShelufu obandisiweyo
Ngokugcina amanzi, i-HPMC inceda ekuthinteleni ukuzinza kwezinto ezibhakiweyo, ngokwenjenjalo zandisa ubomi bazo kwishelufu.Oku kubaluleke kakhulu kwiimveliso ezifana nesonka kunye neekeyiki, apho ukugcinwa kokufuma ngundoqo ekugcineni ubutsha ngokuhamba kwexesha.
c.UkuNcitshiswa kweOli yokuNcitshiswa
Ekutyeni okuqhotsiweyo, i-HPMC inokwenza umqobo onciphisa ukunyuswa kweoli ngexesha lokuqhotsa.Oku akugcini nje ukwenza ukutya kungabi greasy kodwa kunempilo ngokunciphisa umxholo wamafutha.
5. Iipeyinti kunye neeNgqungquthela
a.Iipropati zeSicelo eziPhuculweyo
Kwiipeyinti kunye neengubo, i-HPMC isebenza njenge-ejenti yokuqina kwaye iphucula iimpawu zesicelo.Ikhono layo lokugcinwa kwamanzi liqinisekisa ukuba ipeyinti ayimile ngokukhawuleza, ivumela isicelo esilula kunye nesifanayo ngaphandle kweempawu zebrashi okanye i-streaks.
b.Ukomelezwa koKuhlala ixesha elide
I-HPMC inceda ekugcineni ibhalansi yokufuma kwiipeyinti ezisekelwe emanzini kunye neengubo, ukuthintela ukomisa kwangaphambi kwexesha kunye nokuqhekeka.Oku kwandisa ukuqina kunye nobomi obude bomphezulu opeyintiweyo, ngakumbi kwiindawo ezingqongileyo ezinamaqondo okufuma aguquguqukayo.
6. Izicelo zezoLimo
a.UkuGcinwa kokuGcina ukufuma komhlaba
I-HPMC isetyenziswa kwezolimo ukuphucula ukugcinwa kokufuma komhlaba.Xa igalelwe emhlabeni, inceda ukugcina amanzi, iwenza afumaneke kwizityalo ixesha elide.Oku kuluncedo kakhulu kwimimandla ebharhileyo apho ulondolozo lwamanzi lubalulekile ukuze siphile.
b.Iingubo eziphuculweyo zembewu
Kwimixube yokwaleka kwembewu, i-HPMC iqinisekisa ukuba i-coating ihlala injalo kwaye ine-hydrated, iququzelela amazinga angcono wokuntshula.Ukufuma okugciniweyo kunceda ekukhululweni kancinci kancinci kwezondlo kunye nezikhuseli, zibonelela ngemekobume efanelekileyo yokukhula kwezithole.
Iipropati zokugcina amanzi ze-HPMC zibonelela ngeenzuzo ezibalulekileyo kuluhlu olubanzi lwamashishini.Ekwakhiweni, kwandisa ukusebenza, ukunamathela, kunye neenkqubo zokunyanga.Kwimichiza, ibonelela ngokukhululwa okulawulwayo, ukuzinza, kunye nokuphuculwa kwe-bioavailability.Iimveliso zokhathalelo lomntu zixhamla ekuphuculeni ukuthungwa, ukufuma, kunye nokuzinza.Kwishishini lokutya, i-HPMC iphucula ukuthungwa, yandisa ubomi beshelufu, kwaye iyanciphisa ukufunyanwa kweoyile.Iipeyinti kunye nezaleko zixhamla kwiipropati ezingcono zokufakela kunye nokuqina okuphuculweyo, ngelixa izicelo zezolimo zibona ukugcinwa kokufuma komhlaba okuphuculweyo kunye nokuntshula kwembewu.
Ixesha lokuposa: Jun-03-2024