Yintoni i-hypromellose phthalate?

I-Hypromellose phthalate (HPMCP) luhlobo lwe-excipient ye-pharmaceutical esetyenziswa ekuqulunqweni kweefom zedosi yomlomo, ngokukodwa kwimveliso yeepilisi kunye neepilisi ezifakwe kwi-enteric. Ithathwe kwi-cellulose, eyipolymer yendalo eyenza icandelo lesakhiwo seendonga zesityalo. I-HPMCP i-soluble yamanzi, i-polymer ye-anionic esetyenziswa ngokuqhelekileyo njengento yokugqoka i-enteric ngenxa yeempawu zayo ezibalaseleyo zokwenza ifilimu, ukuzinza, kunye nokuchasana nolwelo lwesisu.

I-HPMCP yaziswa okokuqala ekuqaleni kweminyaka yoo-1970 kwaye ukusukela oko yaba sisixhobo sokugquma se-enteric esisetyenziswa ngokubanzi ngenxa yeempawu zayo ezizodwa. Iveliswa nge-esterification ye-hypromellose nge-phthalic acid kwaye ifumaneka kuluhlu lwamabakala ahlukeneyo, kuxhomekeke kwinqanaba le-phthalation kunye nobunzima bemolekyuli yepolymer. Awona mabanga asetyenziswa ngokuqhelekileyo e-HPMCP yi-HPMCP-55, i-HPMCP-50, kunye ne-HPMCP-HP-55, enamaqondo ahlukeneyo e-phthalation kwaye afanele ukusetyenziswa kwiintlobo ezahlukeneyo zokuqulunqa.

Umsebenzi oyintloko we-HPMCP ekuqulunqweni kwamachiza kukukhusela izithako ezisebenzayo zeyeza ekuthotyweni kwimeko ye-asidi yesisu. Xa i-tablet okanye i-capsule equkethe i-HPMCP ifakwe, i-coating ihlala ihambelana nesisu ngenxa ye-pH ephantsi, kodwa xa ifom ye-dosage ifikelela kwindawo ye-alkaline yamathumbu amancinci, i-coating iqala ukuchithwa kwaye ikhulule izithako ezisebenzayo. Oku kukhutshwa kulibaziseka kunceda ekuqinisekiseni ukuba iyeza lihanjiswa kwindawo yesenzo kwaye ukusebenza kwayo akuthintelwa yi-asidi yesisu.