Focus on Cellulose ethers

Ubudlelwane phakathi kwe-HPMC viscosity kunye nobushushu kunye nezilumkiso

I-HPMC (i-hydroxypropyl methylcellulose) yinto esetyenziswa ngokuqhelekileyo kwiyeza elisetyenziswa ekuveliseni iintlobo ngeentlobo zeedosi zonyango, kubandakanywa iipilisi, iipilisi, neemveliso zamehlo. Enye yezinto eziphambili ze-HPMC yi-viscosity yayo, echaphazela iipropati zemveliso yokugqibela. Eli nqaku liza kuphonononga ubudlelwane phakathi kwe-HPMC viscosity kunye nobushushu kwaye liqaqambise amanye amanyathelo okhuseleko ekufuneka athatyathwe xa usebenzisa le excipient.

Ubudlelwane phakathi kwe-HPMC viscosity kunye nobushushu

HPMC yi polima hydrophilic ukuba ukunyibilika emanzini kunye nezinye izinyibilikisi polar. Xa i-HPMC ichithwa emanzini, yenza isisombululo se-viscous ngenxa yobunzima be-polymer ephezulu kunye neqondo eliphezulu le-hydrophilicity. I-viscosity yezisombululo ze-HPMC zichatshazelwa zizinto ezininzi, kubandakanywa ukuxinwa kwepolymer, ubushushu besisombululo, kunye ne-pH ye-solvent.

Enye yezinto eziphambili ezichaphazela i-viscosity yesisombululo se-HPMC yiqondo lokushisa. I-viscosity yezisombululo ze-HPMC iyancipha ngokunyuka kobushushu. Oku kungenxa yokuba kumaqondo obushushu aphezulu, amakhonkco epolymer aba lulwelo ngakumbi, okukhokelela kumandla ambalwa e-intermolecular abambe amakhonkco epolymer kunye. Ngenxa yoko, i-viscosity yesisombululo iyancipha kwaye i-fluidity yesisombululo iyanda.

Ubudlelwane phakathi kobushushu kunye ne-HPMC viscosity inokuchazwa yi-equation ye-Arrhenius. I-equation ye-Arrhenius yi-equation yemathematika echaza ubudlelwane phakathi kwesantya sokusabela kweekhemikhali kunye nobushushu benkqubo. Kwizisombululo ze-HPMC, i-equation ye-Arrhenius ingasetyenziselwa ukuchaza ubudlelwane phakathi kwe-viscosity yesisombululo kunye nobushushu benkqubo.

I-equation yeArrhenius inikwa ngu:

k = Ae^(-Ea/RT)

apho u-k ngumlinganiselo womlinganiselo, A yi-pre-exponential factor, i-Ea yi-activation yamandla, i-R yi-gas engaguqukiyo, kunye no-T bubushushu benkqubo. I-viscosity yezisombululo ze-HPMC ihambelana nesantya sokuhamba kwe-solvent ngokusebenzisa i-matrix ye-polymer, elawulwa ngumgaqo ofanayo kunye nesantya sokuphendula kweekhemikhali. Ngoko ke, i-equation ye-Arrhenius ingasetyenziselwa ukuchaza ubudlelwane phakathi kwe-viscosity yesisombululo kunye nobushushu benkqubo.

Izinto ukuba uqaphele xa usebenzisa HPMC

Xa kusetyenzwa ne-HPMC, kufuneka kuthathwe amanyathelo okhuseleko amaninzi ukuze kuqinisekiswe ukuphathwa ngokukhuselekileyo nangokufanelekileyo kwepolymer. La manyathelo okhuseleko abandakanya:

1. Sebenzisa izixhobo zokukhusela

Kubalulekile ukusebenzisa izixhobo ezikhuselayo ezifana neeglavu, iiglasi, kunye needyasi zaselebhu xa uphethe i-HPMC. Oku kungenxa yokuba i-HPMC inokucaphukisa ulusu kunye namehlo, kwaye inokubangela iingxaki zokuphefumla ukuba itsalwe. Ke ngoko, kubalulekile ukuthatha amanyathelo okunciphisa umngcipheko wokuvezwa kwiipolymers.

2. Gcina i-HPMC ngokuchanekileyo

I-HPMC kufuneka igcinwe kwindawo epholileyo, eyomileyo ukuthintela ukufunxwa kokufuma emoyeni. Oku kungenxa yokuba i-HPMC i-hygroscopic, oku kuthetha ukuba ifunxa ukufuma kwindawo eyingqongileyo. Ukuba i-HPMC ifunxa ukufuma kakhulu, inokuchaphazela i-viscosity kunye neempawu zemveliso yokugqibela.

3. Nika ingqalelo kugxininiso kunye nobushushu

Xa uqulunqa kunye ne-HPMC, qiniseka ukuba ubeke ingqalelo kugxininiso kunye nobushushu besisombululo. Oku kungenxa yokuba i-viscosity yezisombululo ze-HPMC imiselwa kakhulu zezi zinto. Ukuba ugxininiso okanye ukushisa kuphezulu kakhulu okanye kuphantsi kakhulu, kuya kuchaphazela i-viscosity kunye neempawu zemveliso yokugqibela.

4. Sebenzisa iindlela ezifanelekileyo zokusebenza

Xa kusetyenzwa i-HPMC, kubalulekile ukusebenzisa iindlela ezifanelekileyo zokucwangcisa ukuqinisekisa ukuphathwa ngokukhuselekileyo nangokufanelekileyo kwepolymer. Oku kunokubandakanya ukusebenzisa iindlela zokucheba ezisezantsi ukuthintela ukuchetywa kwepolymer okanye ukwaphuka, okanye ukusebenzisa iindlela ezifanelekileyo zokomisa ukususa ukufuma okugqithisileyo kwimveliso yokugqibela.

5. Khangela ukuhambelana

Xa usebenzisa i-HPMC njenge-excipient, kubalulekile ukujonga ukuhambelana nezinye izinto ezincedisayo kunye nezithako ezisebenzayo ekuqulunqweni. Oku kungenxa yokuba i-HPMC inokusebenzisana nezinye izithako ekuqulunqweni, ezichaphazela ukusebenza kunye nokuzinza kwemveliso yokugqibela. Ke ngoko, kubalulekile ukwenza izifundo zokuhambelana ukuchonga nayiphi na imiba enokubakho ngaphambi kokuqhubeka nokuqulunqa.

ukuququmbela

I-viscosity yezisombululo ze-HPMC ichatshazelwa zizinto ezininzi, ezibandakanya ukugxila, ubushushu, kunye ne-pH. I-viscosity yezisombululo ze-HPMC iyancipha ngokunyuka kwamaqondo obushushu ngenxa yokunyuka kokuhamba kwamakhonkco e-polymer. Xa usebenza ne-HPMC, kubalulekile ukuthatha amanyathelo okhuseleko afanelekileyo ukuqinisekisa ukuphathwa ngokukhuselekileyo nangokufanelekileyo kwepolymer. Ezi zilumkiso zibandakanya ukusebenzisa izixhobo zokukhusela, ukugcina ngokufanelekileyo i-HPMC, ukunikela ingqalelo ekugxininiseni kunye nobushushu, ukusebenzisa iindlela ezifanelekileyo zokucubungula, kunye nokujonga ukuhambelana nezinye izithako kwifomula. Ngokuthatha la manyathelo okhuseleko, i-HPMC ingasetyenziswa njenge-excipient esebenzayo kwiifom ezahlukeneyo zedosi yamayeza.


Ixesha lokuposa: Sep-25-2023
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