Ubudlelwane phakathi kwe-HPMC Viscofity kunye neqondo lobushushu kunye nezilumkiso

I-HPMC (i-hydroxypropyl methylcelcelsulose) ingaba ulungelelwaniso oluqhelekileyo oluqhelekileyo olusetyenzisiweyo ekuvelisweni kweefom zethamo ezahlukeneyo zamayeza, kubandakanya neetafile, kunye neemveliso ze-ophthalmic. Enye yeendawo eziphambili ze-HPMC l Viscofity, echaphazela iipropathi zemveliso yokugqibela. Eli nqaku liza kuphonononga ubudlelwane phakathi kwe-HPMC Viscosity kunye neqondo lokushisa kunye nokuqaqambisa amanyathelo okhuseleko ekufuneka athatyathwe xa esebenzisa le nto.

Ubudlelwane phakathi kwe-HPMC Viscofity kunye neqondo lobushushu

I-HPMC yiPolymer ye-hydrophilic enyibilikayo emanzini nakwezinye izinto zepolar. Xa i-HPMC ichithwe emanzini, yenza isisombululo se-viscous ngenxa yobunzima bemolekyuli ephezulu ye-polymer kunye nenqanaba eliphezulu le-hydrophicicity. UVenkile weZilungithi ze-HPMC uyachaphazeleka ngezinto ezininzi, kubandakanya uxinzelelo lwe-polymer, ubushushu besisombululo, kunye ne-PH yesolvent.

Enye yezinto eziphambili ezichaphazela uVeksinity weSisombululo se-HPMC lishushu. Uhlobo lwe-viscosity yezisombululo ze-HPMC unciphisa iqondo lobushushu esandayo. Kungenxa yokuba kumaqondo obushushu aphezulu, amakhonkco ePolymer abe ngamanzi, ophumela kumanzi amancinci abantu abaphethe amakhonkco ePolymer kunye. Ngenxa yoko, uVekyusi wesisombululo uyancipha kwaye ulwelo lwesisombululo luyanda.

Ulwalamano phakathi kobushushu kunye notyelelo lwe-HPMC lungachazwa nguMgaqo-nkqubo we-Ackenius. I-Ackenius Equation yi-iquation yemathematics echaza ubudlelwane phakathi kwenqanaba lokuphendula kwemichiza kunye neqondo lobushushu lenkqubo. Kwizisombululo ze-HPMC, i-Ackenius Enxarition ingasetyenziselwa ukuchaza ubudlelwane phakathi kwesisombululo kunye neqondo lokushisa.

Unikwe i-Sheenius Equation yi:

k = ae ^ (- e / rt)

Apho i-K ihamba rhoqo, i-A is filtone ye-pre-exponetiant, i-EA yimisebenzi yokuvula, r yirhasi rhoqo, kwaye iqondo lobushushu lenkqubo. UVenkile weZilungithi ze-HPMC uhambelana nenqanaba lokuhamba kwesolholo nge-polymer matrix, elawulwa ngumgaqo ofanayo nenqanaba lokuphendula kwekhemikhali. Ke ngoko, i-Arhenius iforation ingasetyenziselwa ukuchaza ubudlelwane phakathi kwesisombululo sesisombululo kunye neqondo lokushisa.

Izinto zokuphawula xa usebenzisa i-HPMC

Xa usebenza ne-HPMC, kufuneka kuthathwe amanyathelo okhuseleko ukuze kuqinisekiswe ukuthathwa ngokukhuselekileyo kwePolymer. Ezi zixhobo zibandakanya:

1. Sebenzisa izixhobo zokukhusela

Kubalulekile ukusebenzisa izixhobo ezikhuselayo ezinje ngeegloves, iigogles, kunye neelebhu zelebhu xa iphatha i-HPMC. Kungenxa yokuba i-HPMC inokucaphukisa ulusu kunye namehlo, kwaye inokubangela iingxaki zokuphefumla ukuba ukhulelwe. Ke ngoko, kubalulekile ukuthatha amanyathelo ukunciphisa umngcipheko wokuvezwa kwee-polymers.

2. Gcina i-HPMC ngokuchanekileyo

I-HPMC kufuneka igcinwe kwindawo epholileyo, eyomileyo ukuthintela ukufunxa umswakama emoyeni. Kungenxa yokuba i-HPMC i-hygroscopic, oko kuthetha ukuba ifumana i-rarimation kwindawo yayo engqongileyo. Ukuba i-HPMC ifumana ukufuma kakhulu umswakama, inokuchaphazela i-viscofity kunye neepropathi zemveliso yokugqibela.

3. Nika ingqalelo kuxinzelelo kunye nobushushu

Xa ulungiselela i-HPMC, qiniseka ukuba unika ingqalelo kuxinzelelo kunye nobushushu besisombululo. Kungenxa yokuba ukubonwa kwezisombululo ze-HPMC kumiselwe ikakhulu zizinto. Ukuba uxinzelelo okanye iqondo lobushushu liphezulu kakhulu okanye liphantsi kakhulu, liya kuchaphazela i-viscofity kunye neepropathi zemveliso yokugqibela.

I-4. Sebenzisa iindlela ezifanelekileyo zokulungisa

Xa iqhuba i-HPMC, kubalulekile ukusebenzisa iindlela ezifanelekileyo zokulungisa ukuqinisekisa ukuphatha ngokukhuselekileyo kwePolymer. Oku kunokubandakanya ukusebenzisa iindlela zokuxubana eziphantsi ze-Shear ukuthintela ukucheba i-polymer okanye ukuqhekeza, okanye ukusebenzisa iindlela ezifanelekileyo zokomisa ukususa umswakama okuphezulu kwimveliso yokugqibela.

I-5. Jonga ulungelelwano

Xa usebenzisa i-HPMC njengomculo, kubalulekile ukukhangela ukuhambelana nabanye abanomdla kunye nezithako ezisebenzayo ekuqulunqweni. Kungenxa yokuba i-HPMC inokunxibelelana nezinye izithako ekuqulunqweni, ichaphazela ukusebenza kunye nokuzinza kwemveliso yokugqibela. Ke ngoko, kubalulekile ukwenza izifundo zengqikelelo yokuchonga nayiphi na imiba enokubakho ngaphambi kokuba uqhubeke nokuqulunqwa.

ukuququmbela

UVenkile weZisombululo ze-HPMC uyachaphazeleka ngezinto ezininzi, kubandakanya uxinzelelo, ubushushu kunye ne-pH. Uhlobo lwe-viscosity yezisombululo ze-HPMC unciphisa ubushushu obukhulayo ngenxa yokunyuka kokuhamba kwamakhonkco ePolymer. Xa usebenza ne-HPMC, kubalulekile ukuthatha amanyathelo okhuseleko ukuqinisekisa ukuphatha ngokukhuselekileyo kwePolymer. Ezi zixhobo zibandakanya ukusebenzisa izixhobo ezikhuselayo, ukugcina ngokufanelekileyo i-HPMC, ukunikela ingqalelo kuxinzelelo kunye nobushushu, ukusebenzisa iindlela ezifanelekileyo zokulungisa, kunye nokujonga ukuhambelana nezinye izithako kwifomula. Ngokuthatha olu manyathelo okhuseleko, i-HPMC inokusetyenziswa njengokungafaniyo ngempumelelo kwiifom zethamo ezahlukeneyo zamayeza.