I-HPMC yi-semi-synthetic polymer ephuma kwi-cellulose. Ngenxa yokuqina kwayo okugqwesileyo, ukuzinzisa kunye neempawu zokwenza ifilimu, isetyenziswa kakhulu kumayeza, ukutya, izithambiso kunye namanye amashishini. Ukufunda ukuziphatha kwayo kwe-viscosity kubalulekile ukunyusa ukusebenza kwayo kwizicelo ezahlukeneyo.
1. Umlinganiselo weViscosity:
I-Viscometer ejikelezayo: I-viscometer ejikelezayo ilinganisa i-torque efunekayo ukujikeleza i-spindle ngesantya esiqhubekayo xa ibhaptizwa kwisampuli. Ngokutshintsha ijometri kunye nesantya sokujikeleza se-spindle, i-viscosity kumazinga ahlukeneyo okucheba inokumiselwa. Le ndlela yenza ukubonakaliswa kwe-viscosity ye-HPMC phantsi kweemeko ezahlukeneyo.
I-Capillary Viscometer: I-capillary viscometer ilinganisa ukuhamba kolwelo ngetyhubhu ye-capillary phantsi kwefuthe lomxhuzulane okanye uxinzelelo. Isisombululo se-HPMC sinyanzeliswa ngetyhubhu ye-capillary kwaye i-viscosity ibalwa ngokusekelwe kwisantya sokuhamba kunye nokuhla koxinzelelo. Le ndlela ingasetyenziselwa ukufunda i-HPMC viscosity kumazinga asezantsi okucheba.
2.Umlinganiselo weRheological:
I-Dynamic Shear Rheometry (DSR): I-DSR ilinganisa impendulo yezinto eziphathekayo kwi-deformation ye-shear eguquguqukayo. Iisampulu ze-HPMC ziphantsi koxinzelelo lwe-oscillatory shear kwaye iziphumo ezifunyenweyo zalinganiswa. Ukuziphatha kwe-viscoelastic yezisombululo ze-HPMC kunokubonakaliswa ngokuhlalutya i-viscosity eyinkimbinkimbi (η *) kunye nemodyuli yokugcina (G') kunye nemodyuli yokulahleka (G").
Iimvavanyo ze-Creep kunye nokubuyisela: Olu vavanyo lubandakanya ukubeka iisampulu ze-HPMC kuxinzelelo oluqhubekayo okanye uxinzelelo ixesha elide (isigaba se-creep) kunye nokubeka esweni ukuchacha okulandelayo emva koxinzelelo okanye uxinzelelo. Ukuziphatha kwe-Creep kunye nokubuyisela kunika ingqiqo kwiipropati ze-viscoelastic ze-HPMC, kuquka ukuguqulwa kwayo kunye nokukwazi ukubuyisela.
3. Izifundo ezixhomekeke kugxininiso kunye nobushushu:
Ukujongwa kweSkena: Imilinganiselo ye-Viscosity yenziwa kuluhlu lokugxininiswa kwe-HPMC ukufunda ubudlelwane phakathi kwe-viscosity kunye nokugxilwa kwepolymer. Oku kunceda ukuqonda ukusebenza kakuhle kwepolymer kunye nokuziphatha kwayo okuxhomekeke kugxininiso.
Ubushushu scan: imilinganiselo Viscosity lwenziwa kumaqondo obushushu ezahlukeneyo ukufunda ifuthe lobushushu kwi viscosity HPMC. Ukuqonda ukuxhomekeka kweqondo lobushushu kubalulekile kwizicelo apho ii-HPMCs zifumana utshintsho lobushushu, olufana nolwakhiwo lwamayeza.
4. Uhlalutyo lobunzima bemolekyuli:
Ubungakanani bokungabikho kweChromatography (SEC): I-SEC yahlula iimolekyuli zepolymer ngokusekelwe kubungakanani bazo kwisisombululo. Ngokuhlalutya iprofayili ye-lution, ukuhanjiswa kobunzima bemolekyuli yesampulu ye-HPMC kunokumiselwa. Ukuqonda ubudlelwane phakathi kobunzima bemolekyuli kunye ne-viscosity kubalulekile ukuqikelela indlela yokuziphatha kwe-rheological ye-HPMC.
5. Ukwenza iModeli kunye nokulinganisa:
Iimodeli zethiyori: Iimodeli ezahlukeneyo zethiyori, njengemodeli yeCarreau-Yasuda, imodeli yoMnqamlezo okanye imodeli yomthetho wamandla, ingasetyenziselwa ukuchaza ukuziphatha kwe-viscosity ye-HPMC phantsi kweemeko ezahlukeneyo zokucheba. Ezi modeli zidibanisa iiparamitha ezinje ngereyithi yokucheba, ukugxininiswa, kunye nobunzima bemolekyuli ukuqikelela ngokuchanekileyo i-viscosity.
Ukulinganisa okuBaliweyo: Ukulinganisa okuFanelekileyo okuFakwayo (i-CFD) kukubonelela ngengqiqo kwindlela yokuziphatha ye-HPMC kwiijiyometri ezinzima. Ngokusombulula ngokwamanani ii-equations ezilawulayo zokuhamba kwamanzi, ukulinganisa kweCFD kunokuqikelela ukuhanjiswa kwe-viscosity kunye neepateni zokuhamba phantsi kweemeko ezahlukeneyo.
6. Izifundo ze-In situ kunye ne-in vitro:
Imilinganiselo ye-in-situ: Ubuchule be-in-situ bubandakanya ukufunda utshintsho lwe-viscosity yexesha langempela kwindawo ethile okanye isicelo. Ngokomzekelo, ekuqulunqweni kwamayeza, imilinganiselo ye-situ inokubeka iliso kwinguqu ye-viscosity ngexesha lokuchithwa kwethebhulethi okanye ukusetyenziswa kwejeli ye-topical.
Uvavanyo lwe-in vitro: Uvavanyo lwe-in vitro lulinganisa iimeko ze-physiological ukuvavanya ukuziphatha kwe-viscosity ye-HPMC-based formulations eyenzelwe ukulawulwa komlomo, i-ocular, okanye i-topical. Ezi mvavanyo zibonelela ngolwazi oluxabisekileyo malunga nokusebenza kunye nokuzinza koqulunqo phantsi kweemeko ezifanelekileyo zebhayoloji.
7.Itekhnoloji ephezulu:
IMicrorheology: Ubuchule beMicrorheology, obunjengokusasazwa kokukhanya okuguquguqukayo (DLS) okanye i-microrheology yokulandelela amasuntswana (PTM), ivumela ukuphonononga iipropathi ze-viscoelastic zolwelo oluntsonkothileyo kwisikali se-microscopic. Ezi ndlela zobuchule zinokunika ukuqonda kwindlela yokuziphatha kwe-HPMC kwinqanaba leemolekyuli, ehambelana nemilinganiselo ye-rheological macroscopic.
I-Nuclear Magnetic Resonance (NMR) ISpectroscopy: I-NMR spectroscopy ingasetyenziselwa ukufunda iintshukumo zemolekyuli kunye nonxibelelwano lwe-HPMC kwisisombululo. Ngokubeka esweni utshintsho lweekhemikhali kunye namaxesha okuphumla, i-NMR ibonelela ngolwazi oluxabisekileyo malunga notshintsho lwe-HPMC oluhambelanayo kunye nokusebenzisana kwe-polymer-solvent echaphazela i-viscosity.
Ukufunda ngokuziphatha kwe-viscosity ye-HPMC kufuna indlela ye-multidisciplinary, kubandakanywa ubuchule bokulinga, imodeli yethiyori, kunye neendlela zokuhlalutya eziphambili. Ngokusebenzisa indibaniselwano ye-viscometry, i-rheometry, uhlalutyo lwe-molecular, imodeli, kunye nobuchule obuphambili, abaphandi banokufumana ukuqonda okupheleleyo kweempawu ze-rheological ze-HPMC kunye nokwandisa ukusebenza kwayo kwiinkqubo ezahlukeneyo.
Ixesha lokuposa: Feb-29-2024