Iipropati zeHydroxyethyl Methyl Cellulose

I-Hydroxyethyl Methyl Cellulose (HEMC) iphuma kwi-cellulose yendalo ye-polymer. Yipolymer enyibilikayo emanzini eyenziwe emva kokuguqulwa kweekhemikhali kwaye inoluhlu olubanzi lwezicelo. Njenge-ether ye-cellulose e-soluble ebalulekileyo yamanzi, inezinto ezininzi ezikhethekileyo zomzimba kunye neekhemikhali kwaye isetyenziswa ngokubanzi kulwakhiwo, iingubo, izimonyo, ukutya kunye namayeza.

1. Ubume beMichiza kunye nokwakheka
I-Hydroxyethyl methyl cellulose yi-cellulose elungisiweyo eyenziwe yi-etherification reaction ye-cellulose ene-ethylene oxide (epoxy) kunye ne-methyl chloride emva konyango lwe-alkali. Ubume bayo beekhemikhali buqulethe i-cellulose skeleton kunye neendawo ezimbini, i-hydroxyethyl kunye ne-methoxy. Ukuqaliswa kwe-hydroxyethyl kunokuphucula ukunyibilika kwamanzi, ngelixa ukuqaliswa kwe-methoxy kunokuphucula i-hydrophobicity yayo, okwenza kube nesisombululo esingcono sokuzinza kunye nokusebenza kwefilimu.

2. Ukunyibilika
I-Hydroxyethyl methyl cellulose yi-ether ye-cellulose engekho i-ionic ene-solubility efanelekileyo yamanzi, enokuthi inyibilike emanzini abandayo kunye namanzi ashushu. Ayisebenzi ngee-ion emanzini xa inyibilika, ngoko ke ine-solubility egqwesileyo phantsi kweemeko ezahlukeneyo zamanzi. Inkqubo yokutshatyalaliswa idinga ukuba ihlakazeke ngokulinganayo emanzini abandayo kuqala, kwaye emva kwexesha lokuvuvukala, isisombululo esifanayo kunye nesicacileyo senziwe ngokuthe ngcembe. Kwi-solvents ye-organic, i-HEMC ibonisa ukunyibilika kwenxalenye, ngakumbi kwi-solvents ephezulu ye-polar efana ne-ethanol kunye ne-ethylene glycol, enokuthi iyinyibilikise ngokuyinxenye.

3. I-Viscosity
I-viscosity ye-HEMC yenye yezona zinto zibaluleke kakhulu kwaye isetyenziswa ngokubanzi ekuxubeni, ukumiswa kunye nokwenza ifilimu. I-viscosity yayo iyatshintsha kunye nokutshintsha koxinzelelo, ubushushu kunye nesantya sokucheba. Ngokubanzi, i-viscosity yesisombululo iyanda kakhulu ngokunyuka kwesisombululo soxinzelelo. Isisombululo esinogxininiso oluphezulu sibonisa i-viscosity ephezulu kwaye ifanelekile ukusetyenziswa njenge-thickener yezinto zokwakha, iingubo kunye ne-adhesives. Ngaphakathi kweqondo elithile lokushisa, i-viscosity yesisombululo se-HEMC iyancipha ngokunyuka kweqondo lokushisa, kwaye le propati yenza ukuba ifaneleke kwizicelo zoshishino phantsi kweemeko ezahlukeneyo zokushisa.

4. Ukuzinza kwe-thermal
IHydroxyethyl methylcellulose ibonisa ukuzinza okuhle kwe-thermal kumaqondo obushushu aphezulu kwaye inokumelana nobushushu obuthile. Ngokuqhelekileyo, phantsi kweemeko eziphezulu zokushisa (ezinje ngaphezu kwe-100 ° C), isakhiwo sayo se-molecular sizinzile kwaye akulula ukubola okanye ukuthotywa. Oku kuvumela i-HEMC ukuba igcine ukuqina kwayo, ukugcinwa kwamanzi kunye neepropati zokubambisana kwiindawo eziphezulu zokushisa kwishishini lokwakha (njengenkqubo yokomisa udaka) ngaphandle kokungasebenzi kakuhle ngenxa yokutshintsha kweqondo lokushisa.

5. Ukutyeba
I-HEMC ineempawu ezigqwesileyo zokujiya kwaye sisisityebi esisebenza kakhulu esisetyenziswa ngokubanzi kwiinkqubo ezahlukeneyo zokuyila. Inokunyusa ngokufanelekileyo i-viscosity yezisombululo ezinamanzi, i-emulsions kunye nokumiswa, kwaye ineempawu ezintle zokucheba. Kwizinga eliphantsi le-shear, i-HEMC inokunyusa kakhulu i-viscosity yenkqubo, ngelixa kumazinga aphezulu e-shear ibonisa i-viscosity ephantsi, enceda ukuphucula ukulungelelaniswa komsebenzi ngexesha lokusetyenziswa. Umphumo wayo wokuqina awuhambelani kuphela nokugxininiswa, kodwa uchaphazelekayo ngexabiso le-pH kunye nokushisa kwesisombululo.

6. Ukugcinwa kwamanzi
I-HEMC isoloko isetyenziswa njenge-arhente yokugcina amanzi kushishino lokwakha. Ukugcinwa kwayo kwamanzi okugqwesileyo kunokwandisa ixesha lokuphendula kwe-hydration yezinto ezisekelwe kwi-samente kunye nokuphucula ukusebenza komsebenzi kunye nokubambelela kwidaka lokwakha. Ngethuba lenkqubo yokwakha, i-HEMC inokunciphisa ngokufanelekileyo ukulahlekelwa kwamanzi kwaye igweme iingxaki ezifana nokuqhekeka kunye nokulahlekelwa kwamandla okubangelwa ukomisa ngokukhawuleza kodaka. Ukongezelela, kwiipeyinti ezisekelwe kumanzi kunye neenki, ukugcinwa kwamanzi kwe-HEMC kunokugcina umbane wepeyinti, ukuphucula ukusebenza kokwakhiwa kwepeyinti kunye nokuhamba kakuhle kwendawo.

7. Biocompatibility kunye nokhuseleko
Ngenxa yokuba i-HEMC ivela kwi-cellulose yendalo, ine-biocompatibility efanelekileyo kunye ne-toxicity ephantsi. Ke ngoko, sele isetyenziswa kakhulu kwiinkalo zamayeza nakwizinto zokuthambisa. Ingasetyenziselwa njenge-disintegrant okanye i-agent-release-release-release in the tablets ukunceda ukukhululwa okuzinzileyo kweziyobisi emzimbeni. Ukongezelela, njenge-thickener kunye ne-film-forming agent kwi-cosmetics, i-HEMC inokubonelela ngemiphumo yokuthambisa ulusu, kwaye ukhuseleko lwayo oluhle luyenza ilungele ukusetyenziswa kwexesha elide.

8. Iinkalo zesicelo
Ngenxa yemisebenzi emininzi ye-hydroxyethyl methylcellulose, isetyenziswe ngokubanzi kwiinkalo ezininzi zemizi-mveliso:

Ishishini lokwakha: Kwizinto zokwakha ezifana nodaka lwesamente, i-putty powder, kunye neemveliso ze-gypsum, i-HEMC ingasetyenziselwa njenge-thickener, i-agent egcina amanzi, kunye ne-adhesive ukuphucula ukusebenza kokwakhiwa kunye nomgangatho wemveliso ogqityiweyo.
Iingubo kunye neenki: I-HEMC isetyenziswa ngokubanzi kwiipeyinti ezisekelwe emanzini kunye neenki njenge-thickener kunye ne-stabilizer ukuphucula umgangatho, ukuzinza, kunye ne-gloss yepende emva kokumisa.
Intsimi yezoNyango: Njenge-disintegrant, i-adhesive kunye ne-agent-release-release-release in the carrier carriers, inokulawula izinga lokukhululwa kweziyobisi emzimbeni kunye nokuphucula i-bioavailability yamachiza.
Izithambiso kunye neemveliso zokhathalelo lomntu: Kwiimveliso zokhathalelo lomntu ezifana neloshini, iikhrimu, kunye neshampu, iHEMC ingasetyenziswa njengento etyebisayo kunye neyokuthambisa, kwaye inobudlelwane obuhle bolusu kunye neenwele.
Ishishini lokutya: Kwezinye ukutya, i-HEMC ingasetyenziswa njenge-stabilizer, emulsifier kunye ne-agent-forming agent. Nangona ukusetyenziswa kwayo ekutyeni kuxhomekeke kwimiqathango yolawulo kwamanye amazwe, ukhuseleko lwakho luye lwamkelwa ngokubanzi.

9. Uzinzo lwemo engqongileyo kunye nokonakala
Njengezinto ezisekelwe kwi-bio-based, i-HEMC inokutshatyalaliswa ngokuthe ngcembe kwindalo, kwaye inkqubo yokuthotywa kwayo iqhutyelwa ikakhulu yisenzo se-microorganisms. Ke ngoko, i-HEMC inongcoliseko oluncinci kokusingqongileyo emva kokusetyenziswa kwaye iyikhemikhali ehambelana nokusingqongileyo. Ngaphantsi kweemeko zendalo, i-HEMC inokugqiba ukubola emanzini, i-carbon dioxide kunye nezinye iimolekyuli ezincinci, kwaye ayiyi kubangela ukuqokelela kwexesha elide lokungcola emhlabeni kunye namanzi.

IHydroxyethyl methylcellulose yeyona nto ibaluleke kakhulu ephuma kwiselulosi enyibilikayo emanzini. Ngenxa yeempawu zayo ezizodwa zomzimba kunye neekhemikhali ezifana nokutyeba okugqwesileyo, ukugcinwa kwamanzi, ukuzinza kwe-thermal kunye nokuhambelana kwezinto eziphilayo, isetyenziswa ngokubanzi kumashishini amaninzi afana nokwakha, iingubo, amayeza, izithambiso, njl njl. isongezelelo esibalulekileyo esisebenzayo kwiinkqubo ezahlukeneyo zokuqulunqa. Ngokukodwa kwintsimi apho kuyimfuneko ukwandisa i-viscosity yemveliso, ukwandisa ubomi benkonzo okanye ukuphucula ukusebenza komsebenzi, i-HEMC idlala indima engenakulinganiswa. Ngexesha elifanayo, njengento ehambelana nokusingqongileyo, i-HEMC ibonise ukuzinza okulungileyo kwizicelo zoshishino kwaye inethemba elihle lokuthengisa.