I-Hydroxypropyl methylcellulose (i-Hypromellose), eyaziwa ngokuba yi-hypromellose, i-white to white cellulose powder okanye i-granule, eneempawu zokunyibilika kumanzi abandayo kwaye ayinyibiliki emanzini ashushu afana ne-methyl cellulose. Iqela le-hydroxypropyl kunye neqela le-methyl lidibaniswe ne-glucose ye-anhydrous ring ye-cellulose nge-ether bond, eluhlobo lwe-non-ionic cellulose exutywe i-ether. Yi-semisynthetic, engasebenzi, i-viscoelastic polymer edla ngokusetyenziswa njenge-lubricant kwi-ophthalmology, okanye njenge-excipient okanye isithuthi kumayeza omlomo.
ukulungiselela
I-pulp yephepha le-kraft paper pulp efunyenwe kwi-pine wood kunye nomxholo we-alpha cellulose we-97%, i-viscosity yangaphakathi ye-720 ml / g, kunye ne-avareji yefiber ubude be-2.6 mm yantywiliselwa kwi-49% yesisombululo samanzi se-NaOH kwi-40 ° C. imizuzwana engama-50; I-pulp efunyenweyo emva koko yacudiswa ukususa i-49% engaphezulu ye-NaOH enamanzi ukufumana i-alkali cellulose. Umlinganiselo wobunzima (i-49% ye-NaOH isisombululo se-aqueous) ukuya (umxholo oqinileyo kwi-pulp) kwisinyathelo sokukhulelwa kwaba ngu-200. Umlinganiselo wobunzima (umxholo we-NaOH kwi-cellulose ye-alkali efunyenwe ngaloo ndlela) kunye (umxholo oqinileyo kwi-pulp) 1.49. I-alkali cellulose efunyenwe ngaloo ndlela (i-20 kg) yafakwa kwi-reactor yoxinzelelo lwejacket kunye nokuvuselela kwangaphakathi, emva koko ikhutshwe kwaye ihlanjululwe nge-nitrogen ukususa ngokwaneleyo i-oksijini kwi-reactor. Emva koko, ukuvuselela kwangaphakathi kwenziwa ngelixa kulawulwa ubushushu kwi-reactor ukuya kuma-60 ° C. Emva koko, i-2.4 kg ye-dimethyl ether yongezwa, kwaye iqondo lokushisa kwi-reactor lilawulwa ukuba ligcinwe kwi-60 ° C. Emva kokufaka i-dimethyl ether, yongeza i-dichloromethane ukwenzela ukuba i-molar ratio ye (dichloromethane) ukuya (icandelo le-NaOH kwi-alkaline cellulose) yi-1.3, kwaye ungeze i-propylene oxide ukwenza (i-propylene oxide) kunye (kwi-pulp) Umlinganiselo wobunzima bomxholo oqinileyo) yatshintshwa yaba yi-1.97, ngelixa iqondo lokushisa kwi-reactor lilawulwa ukusuka kwi-60 ° C ukuya kwi-80 ° C. Emva kokongezwa kwe-methyl chloride kunye nepropylene oxide, iqondo lokushisa kwi-reactor lilawulwa ukusuka kwi-80 ° C ukuya kuma-90 ° C. Ngaphezu koko, ukusabela kwaqhubeka kwi-90 ° C imizuzu engama-20. Emva koko, irhasi yaphuma umoya kwi-reactor, kwaye emva koko i-hydroxypropyl methylcellulose ekrwada yakhutshwa kwireactor. Ubushushu be-hydroxypropyl methylcellulose ekrwada ngexesha lokukhutshwa yayingama-62 degreesC. I-50% yobungakanani bamasuntswana obungakanani obusekwe kubunzima obongezelekayo obumiselwe ngokusekwe kumlinganiselo we-hydroxypropyl methylcellulose ekrwada edlula kwiindawo zokuvuleka kwezisefu ezintlanu, isisefu ngasinye esinobukhulu obahlukeneyo bokuvula, silinganisiwe. Ngenxa yoko, umyinge we-particle ye-particle ye-coarse particles yayingu-6.2 mm. I-hydroxypropyl methylcellulose ekrwada efunyenwe ngaloo ndlela yaziswa kwi-biaxial kneader eqhubekayo (KRC kneader S1, L/D=10.2, umthamo wangaphakathi we-0.12 ilitha, isantya sokujikeleza 150 rpm) ngesantya se-10 kg / hr, kwaye ukubola kwafunyanwa. yehydroxypropyl methylcellulose ekrwada. Umyinge wesayizi ye-particle yayiyi-1.4 mm njengoko ilinganiswe ngokufanayo kusetyenziswa iisefu ze-5 ezahlukeneyo zobukhulu bokuvula. Kwi-hydroxypropyl methylcellulose ekrwada ebolileyo kwitanki enolawulo lobushushu bebhatyi, yongeza amanzi ashushu kwi-80 ° C kwisixa esinokuthi ( Ubungakanani bobunzima besixa seselulosi) ukuya (ixabiso lilonke lodaka) latshintshwa laya ku-0.1, kwaye kwafunyanwa uludaka. I-slurry yashukunyiswa kwiqondo lokushisa elingaguqukiyo lama-80 ° C imizuzu engama-60. Emva koko, i-slurry yondliwa kwi-preheated rotary filter filter (imveliso ye-BHS-Sonthofen) kunye nesantya sokujikeleza kwe-0.5 rpm. Ubushushu boludaka lwalungama-93°C. I-slurry yanikezelwa kusetyenziswa ipompo, kwaye uxinzelelo lokukhutshwa kompompo lwaluyi-0.2 MPa. Ubungakanani bokuvula isihlunu se-rotary pressure filter yayingu-80 μm, kwaye indawo yokucoca yayiyi-0.12 m 2. I-slurry enikezelwe kwisihluzi soxinzelelo lwe-rotary iguqulelwa kwikhekhe lokucoca ngokucoca. Emva kokubonelela ngomphunga we-0.3 MPa kwikhekhe efunyenwe ngaloo ndlela, amanzi ashushu kwi-95 ° C anikezelwa ngokomlinganiselo wokuba umlinganiselo wobunzima (amanzi ashushu) ukuya (umxholo oqinileyo we-hydroxypropyl methylcellulose emva kokuhlamba) wawuyi-10.0, Emva koko, hluza ngokusebenzisa isihluzo. Amanzi ashushu anikezelwa yimpompo kuxinzelelo lokukhupha lwe-0.2 MPa. Emva kokuba kunikezelwe ngamanzi ashushu, i-steam ye-0.3 MPa yanikezelwa. Emva koko, imveliso ehlanjiweyo kwindawo yokucoca isuswe yi-scraper kwaye ikhutshwe kumatshini wokuhlamba. Amanyathelo ukusuka ekondleni i-slurry ukukhupha imveliso ehlanjiweyo iqhutyelwa ngokuqhubekayo. Njengomphumo wokulinganisa usebenzisa i-hygrometer yohlobo lokumisa ubushushu, umxholo wamanzi wemveliso ehlanjiweyo ngoko ukhutshiwe ngu-52.8%. Imveliso ehlanjiweyo ekhutshiweyo kwisihluzo soxinzelelo olujikelezayo yomiswa kusetyenziswa isomisi somoya kwi-80° C., yaza yacolwa kwisixhobo sokusila sokusila sokusila ukuze kufumaneke i-hydroxypropyl methylcellulose.
isicelo
Le mveliso isetyenziswa njenge-thickener, dispersant, binder, emulsifier kunye ne-stabilizer kushishino lwamalaphu. Ikwasetyenziswa ngokubanzi kwi-synthetic resin, i-petrochemicals, i-ceramics, iphepha, isikhumba, amayeza, ukutya, izinto zokuthambisa kunye namanye amashishini.
Ixesha lokuposa: Nov-15-2022