Pharmacokinetics Of Hydroxypropyl Methyl Cellulose

I-Hydroxypropyl Methylcellulose (HPMC) isetyenziswa ikakhulu njenge-excipient kwimixube yoxubo mayeza kunokuba ibe yinto esebenzayo yoxubo mayeza (API). Ngaloo ndlela, iimpawu zayo ze-pharmacokinetic azifundwanga ngokubanzi okanye zibhalwe phantsi xa kuthelekiswa namachiza asebenzayo. Nangona kunjalo, kubalulekile ukuqonda indlela i-HPMC eziphatha ngayo emzimbeni ukuze kuqinisekiswe ukusetyenziswa kwayo okukhuselekileyo nokusebenzayo kwiimveliso zamayeza. Nalu ushwankathelo olufutshane:

Ukufunxa:

• I-HPMC ayifuntshwanga icocekile ngephecana lesisu ngenxa yobunzima bayo obuphezulu bemolekyuli kunye nendalo ye-hydrophilic. Kunoko, ihlala kwi-lumen yesisu kwaye ikhutshwe kwi-feces.

Ukusasazwa:

• Ekubeni i-HPMC ayifakwanga kumjikelezo wenkqubo, ayisasazeki kwiithishu okanye amalungu emzimbeni.

Imetabolism:

• I-HPMC ayenziwanga ngumzimba. Ifumana ubuncinci kwi-biotransformation kwi-gastrointestinal tract.

Ukuphelisa:

• Eyona ndlela iphambili yokuphelisa i-HPMC kukulindle. I-HPMC engafunxwanga ikhutshwa ingatshintshanga kwilindle. Amanye amaqhekeza amancinci e-HPMC anokuthi athotywe ngokuyinxenye yibhaktiriya yekholoni phambi kokukhutshelwa.

Izinto ezichaphazela i-Pharmacokinetics:

• I-pharmacokinetics ye-HPMC inokuphenjelelwa zizinto ezinjengobunzima bemolekyuli, iqondo lokutshintshwa, kunye neempawu zokuqulunqa (umzekelo, i-tablet matrix, i-coating, i-release mechanism). Ezi zinto zinokuchaphazela umyinge kunye nobungakanani bokuchithwa kwe-HPMC, nto leyo inokuchaphazela ukufunxa kwayo kunye nokupheliswa okulandelayo.

Iingqwalasela zoKhuseleko:

• I-HPMC ngokuqhelekileyo ithathwa njengekhuselekile ukuba isetyenziswe kwimixube yamayeza kwaye inembali ende yokusetyenziswa kwiifom zedosi yomlomo. Kuthathwa njenge-biocompatible kunye ne-non-toxic, kwaye ayifaki inkxalabo ebalulekileyo yokhuseleko ngokwemiqathango ye-pharmacokinetics.

Ukufaneleka kwezonyango:

• Ngelixa iipropathi ze-pharmacokinetic ze-HPMC ngokwayo isenokungabi yokufaneleka ngokuthe ngqo kweklinikhi, ukuqonda ukuziphatha kwayo ekuxutyweni kwamayeza kubalulekile ekuqinisekiseni ukusebenza kwemveliso yeziyobisi, kubandakanywa ukukhutshwa kweziyobisi, i-bioavailability, kunye nokuzinza.

Isishwankathelo, i-Hydroxypropyl Methylcellulose (HPMC) ayifakwanga kwi-systemic circulation kwaye ikhutshwe ngokukodwa ingaguqukiyo kwindle. Iimpawu zayo ze-pharmacokinetic zinqunywe ngokukodwa kwiimpawu ze-physicochemical kunye neempawu zokuqulunqa. Ngelixa i-HPMC ngokwayo ingabonakalisi ukuziphatha okuqhelekileyo kwe-pharmacokinetic njengamachiza asebenzayo, indima yayo njenge-excipie ibalulekile kuqulunqo kunye nokusebenza kweemveliso zoxubo mayeza.