IBanga le-Pharmaceutical Hydroxypropyl Methylcellulose (HPMC) sisixhobo esisetyenziswa ngokuqhelekileyo soxubo mayeza, sisetyenziswa kakhulu kwishishini loxubo mayeza. Yi-semi-synthetic, inert, i-ether ye-cellulose e-soluble yamanzi, eguqulwa ngokwekhemikhali kwi-cellulose yendalo. I-HPMC ine-filimi-forming, i-thickening, i-adhesion, i-suspension kunye ne-anti-caking properties, ngoko inexabiso elibalulekileyo lesicelo kumalungiselelo amayeza.
1. Iimpawu ezisisiseko ze-HPMC
I-HPMC yenziwe ngokutshintsha indawo ye-hydroxyl ye-cellulose kunye ne-hydroxypropyl kunye namaqela e-methoxy. Ubume bayo bemolekyuli buneendawo ezimbini, i-hydroxypropyl kunye ne-methyl, ke ibizwa ngokuba yi-hydroxypropyl methylcellulose. I-HPMC ine-solubility efanelekileyo emanzini, kwaye emva kokuchithwa, yenza isisombululo se-viscous esicacileyo. Njengoko ugxininiso lukhula, i-viscosity nayo iyanda. Ukongeza, i-HPMC inozinzo oluhle lwe-thermal kunye nokuzinza kweekhemikhali, kwaye inokunyamezela okulungileyo kwi-asidi, i-alkali kunye nezisombululo zetyuwa.
2. Ukusetyenziswa kweHPMC kumayeza
I-HPMC isetyenziswa kakhulu kwishishini loxubo-mayeza, ikakhulu kule miba ilandelayo:
a. Itheyibhile yokwaleka
I-HPMC, njengento yokugquma iipilisi, inokugubungela ngokufanelekileyo incasa embi yamachiza, iphucule inkangeleko yamachiza, kwaye inobungqina bokufuma kunye nemiphumo yokuchasana ne-oxidation. Ukongeza, inokwandisa ixesha lokukhululwa kweziyobisi kwi-gastrointestinal tract, ngaloo ndlela ifezekisa iziphumo ezizinzileyo okanye ezilawulwayo zokukhululwa.
b. Izityebi kunye nezibophelelo
Xa ulungiselela ukumiswa, i-emulsions, i-capsules kunye namanye amalungiselelo, i-HPMC, njenge-thickener kunye ne-binder, inokuphucula ukuzinza kunye nokufana kwamalungiselelo. Ngaxeshanye, i-HPMC inokomeleza ubulukhuni kunye nokomelela koomatshini beetafile ukuqinisekisa ukuba amachiza awophuka lula ngexesha lemveliso kunye nokuthuthwa.
c. Amalungiselelo okukhululwa alawulwayo nazinzileyo
I-HPMC isoloko isetyenziswa kumalungiselelo okukhutshwa okulawulwayo kunye nokukhululwa okuqhubekayo ngenxa yokuba ijeli yejeli eyenzayo inokuthintela ukungena kwamanzi kwithebhulethi, ukwenzela ukuba ukuchithwa kunye nokukhululwa kweyeza kulawulwa ngokufanelekileyo. Ngokulungelelanisa i-viscosity kunye ne-dosage ye-HPMC, izinga lokukhululwa kweyeza linokulawulwa ngokuchanekileyo, ixesha lesenzo sechiza linokwandiswa, kwaye ukuphindaphinda kwamayeza kunokuncipha.
d. Njengomhluzi
Kumalungiselelo e-capsule, i-HPMC ingasetyenziswa njenge-filler yokugcwalisa ii-capsules ezingenanto. Xa kuthelekiswa nee-capsules zegelatin zemveli, ii-capsules ze-HPMC zinenzuzo yokuba zithathwe kwisityalo kwaye zingenazo izithako zezilwanyana, ngoko zifanelekile kwimifuno kunye nezigulane ezineenkolelo zonqulo.
3. Ukhuseleko lwe-HPMC
Njengomxhasi woxubo mayeza, i-HPMC ine-biocompatibility elungileyo kunye nokhuseleko. Ayichithwanga yi-enzymes yokugaya kumzimba womntu kwaye ikhutshwe ngokuyinhloko emzimbeni ngokusebenzisa amathumbu, ngoko ayithathi nxaxheba kwinkqubo ye-metabolism yeziyobisi kwaye ayivelisi iziphumo zecala ezinobuthi. I-HPMC isetyenziswe ngokubanzi kumalungiselelo ahlukeneyo omlomo, asematheni kunye natofwayo kwaye yamkelwa yi-pharmacopoeias kwihlabathi jikelele.
4. Amathemba emarike
Ngophuhliso oluqhubekayo lweshishini loxubo-mayeza, iimfuno zomgangatho wamachiza kunye nokhuseleko nazo ziyanda. Ngenxa yeepropati zayo ezizodwa kunye neekhemikhali kunye nokhuseleko olulungileyo, i-HPMC inethemba elibanzi lokusetyenziswa kumalungiselelo amatsha amachiza. Ngokukodwa kwiinkalo zamalungiselelo okukhutshwa okulawulwayo kunye nokukhululwa okuqhubekayo, amachiza e-biological kunye namayeza abantu abakhethekileyo (njengabatya imifuno), imfuno ye-HPMC iya kuqhubeka ikhula.
Njengomxhasi wamachiza amaninzi, ibakala leyeza le-hydroxypropyl methylcellulose lidlale indima ebalulekileyo kwishishini lamachiza kwaye liya kuqhubeka lisetyenziswa ngokubanzi kwaye liphuhliswe kwixesha elizayo.
Ixesha lokuposa: Aug-06-2024