Abaxumi bamayeza Iselulosi Etere

Natural cellulose ether ligama jikelele kuthothoi-cellulose derivativesiveliswe ngokusabela kwe-alkali cellulose kunye nearhente etherifying phantsi kweemeko ezithile. Yimveliso apho amaqela e-hydroxyl kwi-cellulose macromolecules athathwe ngokuyinxenye okanye atshintshwe ngokupheleleyo ngamaqela e-ether. I-cellulose ethers isetyenziswa ngokubanzi kwimimandla yepetroleum, izinto zokwakha, iingubo, ukutya, amayeza kunye neekhemikhali zemihla ngemihla. Kwiinkalo ezahlukeneyo, iimveliso zodidi lwamayeza ziyisiseko esiphakathi kunye nesiphelo esiphezulu soshishino, kunye nexabiso eliphezulu elongezelelweyo. Ngenxa yeemfuno ezingqongqo zomgangatho, ukuveliswa kwe-ether ye-cellulose ether ye-pharmaceutical-grade nako kunzima. Kunokuthiwa umgangatho weemveliso zebakala lonyango unokumela ngokusisiseko amandla obugcisa amashishini e-cellulose ether. I-ether ye-cellulose idla ngokudibaniswa njenge-blocker, i-matrix material kunye ne-thickener ukwenza iipilisi ze-matrix ezikhutshwa ngokuqhubekayo, izinto zokugquma ze-gastric-soluble, i-microcapsule-release-release-release-release-release coating materials, i-release-release-release drug film materials, njl.

I-sodium carboxymethyl cellulose:

ICarboxymethyl cellulose sodium (CMC-Na) luhlobo lwe-cellulose ether enemveliso enkulu kunye nokusetyenziswa ekhaya nakwamanye amazwe. Yi-ionic cellulose ether eyenziwe kwikotoni kunye nemithi ngokusebenzisa i-alkalization kunye ne-etherification nge-chloroacetic acid. I-CMC-Na sisixhobo esixhaphakileyo sokwenza amayeza. Ihlala isetyenziswa njengesibophelelo kumalungiselelo aqinileyo, i-agent ejiyayo, i-ajenti ejiyayo, kunye ne-agent exhomayo ukulungiselela ulwelo. Inokusetyenziswa kwakhona njenge-matrix enyibilikayo yamanzi kunye nefilimu yokwenza ifilimu. Ihlala isetyenziswa njengesixhobo sefilimu yeziyobisi esizinzileyo kunye nethebhulethi ye-matrix ekhutshwa ngokuzinzileyo kumalungiselelo okukhululwa azinzileyo (alawulwayo).

Ukongeza kwi-sodium carboxymethylcellulose njenge-excipient yamayeza, i-croscarmellose sodium inokusetyenziswa njenge-excipient yamayeza. I-Croscarmellose sodium (i-CCMC-Na) yimveliso engenamanzi ye-carboxymethylcellulose ephendula kunye ne-agent edibeneyo kwiqondo lokushisa elithile (40-80 ° C) phantsi kwesenzo se-inorganic acid catalyst kwaye ihlanjululwe. Njenge-agent ye-crosslinking, i-propylene glycol, i-succinic anhydride, i-anhydride ye-maleic kunye ne-adipic anhydride ingasetyenziswa. I-Croscarmellose sodium isetyenziswe njenge-disintegrant kwiipilisi, ii-capsules kunye ne-granules kumalungiselelo omlomo. Ixhomekeke kwi-capillary kunye nemiphumo yokudumba ukuze ihlakazeke. Inokunyanzeliswa okulungileyo kunye namandla anamandla okuqhekeka. Uphononongo lubonise ukuba idigri yokudumba ye-croscarmellose sodium emanzini inkulu kuneyo ye-disintegrants eqhelekileyo efana ne-low-substituted carmellose sodium kunye ne-hydrated microcrystalline cellulose.

Methylcellulose:

I-Methyl cellulose (MC) yi-ether engeyiyo ionic cellulose eyenziwe ngekotoni kunye nemithi ngokusebenzisa i-alkalization kunye ne-methyl chloride etherification. I-Methylcellulose ine-solubility egqwesileyo yamanzi kwaye izinzile kuluhlu lwe-pH2.0 ~ 13.0. Isetyenziswa ngokubanzi kwii-excipients zamachiza, kwaye isetyenziswe kwiipilisi ezingaphantsi kweelwimi, ii-injection ze-intramuscular, amalungiselelo ophthalmic, ii-capsules zomlomo, ukumiswa komlomo, iipilisi zomlomo kunye namalungiselelo e-topical. Ukongeza, kumalungiselelo okukhutshwa okuzinzileyo, i-MC ingasetyenziswa njenge-hydrophilic gel matrix amalungiselelo okukhutshwa okuzinzileyo, izinto zokugquma i-gastric-soluble, izixhobo zokugquma i-microcapsule ezizinzileyo, izixhobo zefilimu zokukhutshwa kweziyobisi, njl.

I-Hydroxypropyl methyl cellulose:

IHydroxypropyl methylcellulose (HPMC) yi-cellulose engeyiyo-ionic exutywe ne-ether eyenziwe kumqhaphu kunye nemithi ngokusebenzisa i-alkalization, i-propylene oxide kunye ne-methyl chloride etherification. Ayinavumba, ayinancasa, ayinatyhefu, iyanyibilika emanzini abandayo kwaye ifakwe ijeli emanzini ashushu. IHydroxypropyl methylcellulose luhlobo oluxutyiweyo lweselulosi ethe imveliso yayo, idosi kunye nomgangatho wayo wenyuka ngokukhawuleza eTshayina kule minyaka ili-15 idlulileyo. Ikwayenye yezona zinto zisetyenziswa kakhulu kumayeza asetyenziswa ekhaya nakwamanye amazwe. iminyaka yembali. Okwangoku, ukusetyenziswa kwe-HPMC kubonakaliswa ikakhulu kule miba mihlanu ilandelayo:

Enye ifana nesibophelelo kunye ne-disintegrant. Njengesibophelelo, i-HPMC inokwenza ichiza libe lula ukumanzisa, kwaye inokwandisa amaxesha amakhulu emva kokufunxa amanzi, ngoko inokuphucula kakhulu izinga lokuchithwa okanye izinga lokukhululwa kwethebhulethi. I-HPMC ine-viscosity eyomeleleyo, enokuphucula i-viscosity yamasuntswana kwaye iphucule ukunyanzeliswa kwezinto eziluhlaza kunye nokuthungwa okucocekileyo okanye okunqabileyo. I-HPMC ene-viscosity ephantsi ingasetyenziswa njenge-binder kunye ne-disintegrant, kwaye abo bane-viscosity ephezulu ingasetyenziswa kuphela njenge-binder.

Okwesibini njengento eqhubekayo kunye nelawulwayo yokukhululwa kumalungiselelo omlomo. I-HPMC sisixhobo esisetyenziswa ngokuqhelekileyo se-hydrogel ye-matrix kumalungiselelo okukhululwa okuqhubekayo. Umgangatho we-viscosity ephantsi (5-50mPa · s) I-HPMC ingasetyenziswa njengesibophelelo, i-viscosifier kunye ne-arhente exhomayo, kunye nebakala le-viscosity ephezulu (4000-100000mPa · s) I-HPMC ingasetyenziselwa ukulungisa imathiriyeli exubeneyo yoThintelo lwe-capsules, i-hydrogel matrix. iipilisi zokukhululwa okwandisiweyo. I-HPMC iyanyibilika kulwelo lwesisu, ineengenelo zokucinezeleka okulungileyo, ulwelo olulungileyo, umthamo oqinileyo wokulayisha ichiza, kunye neempawu zokukhupha ichiza ezingachatshazelwa yi-PH. Yimathiriyeli ethwala i-hydrophilic ebaluleke kakhulu kwiinkqubo zokulungiselela ukukhutshwa okuzinzileyo kwaye ihlala isetyenziswa njenge-Hydrophilic gel matrix kunye nezixhobo zokugquma ukulungiselela ukukhutshwa okuzinzileyo, kunye nezixhobo ezincedisayo kumalungiselelo okudada kwesisu kunye namalungiselelo efilimu yokukhululwa okuqhubekayo.

Eyesithathu ifana ne-ejenti yokufaka ifilimu. I-HPMC ineempawu ezilungileyo zokwenza ifilim. Ifilimu eyenziwe yiyo ifanayo, icacile kwaye inzima, kwaye akulula ukunamathela ngexesha lemveliso. Ngokukodwa kumachiza alula ukufunxa umswakama kwaye angazinzanga, ukuwusebenzisa njengomaleko wokuzihlukanisa unokuphucula kakhulu ukuzinza kweyeza kunye nokuthintela Ifilimu iguqula umbala. I-HPMC ineentlobo ngeentlobo zenkcazo ye-viscosity. Ukuba ikhethwe ngokufanelekileyo, umgangatho kunye nokubonakala kweepilisi ezifakwe kwiipilisi ziphezulu kunezinye izinto. Ukugxininiswa okuqhelekileyo yi-2% ukuya kwi-10%.

Eyesine injengempahla ye-capsule. Kwiminyaka yakutshanje, ngokuqhambuka rhoqo kwezifo zezilwanyana zehlabathi, xa kuthelekiswa neecapsules zegelatin, iicapsules zemifuno ziye zaba yintshatsheli kumashishini amayeza kunye nokutya. I-Pfizer yase-United States ikhuphe ngempumelelo i-HPMC kwizityalo zendalo kwaye ilungiselele ii-capsules zemifuno ye-Vcap TM. Xa kuthelekiswa nee-capsules ze-gelatin zendabuko, ii-capsules zezityalo zineenzuzo zokuguquguquka okubanzi, akukho mngcipheko we-cross-linking reactions kunye nokuzinza okuphezulu. Izinga lokukhutshwa kwechiza lizinzile, kwaye ukungafani komntu ngamnye kuncinci. Emva kokuqhekeka emzimbeni womntu, awufuntshwa kwaye unokukhutshwa. Ngokwemiqathango yokugcinwa, emva kwenani elikhulu leemvavanyo, iphantse ingabikho phantsi kweemeko zokufuma okuphantsi, kwaye iipropati zegobolondo le-capsule zisazinzile phantsi kweemeko zokufuma okuphezulu, kwaye izibonakaliso ze-capsules zezityalo azichaphazeleki phantsi kokugcinwa ngokugqithiseleyo. iimeko. Ngokuqondwa kwabantu ngee-capsules zezityalo kunye nokuguqulwa kweengqikelelo zamayeza oluntu ekhaya nakwamanye amazwe, imfuno yentengiso yee-capsules zezityalo iya kukhula ngokukhawuleza.

Eyesihlanu injenge-arhente exhomayo. Ukulungiswa kolwelo lodidi olumisiweyo luhlobo lwedosi yekliniki esetyenziswa ngokuqhelekileyo, eyinkqubo yokusasazwa okungafaniyo apho amachiza aqinileyo anganyibilikiyo asasazwa kulwelo olusasazwa phakathi. Ukuzinza kwenkqubo kumisela umgangatho wokulungiswa kolwelo lokumiswa. Isisombululo se-HPMC se-colloidal sinokunciphisa ukuxinana kwe-slid-liquid interfacial, ukunciphisa umphezulu wamandla wamahhala wamasuntswana aqinileyo, kunye nokuzinzisa inkqubo yokusasazwa kwe-heterogeneous. Yeyona arhente ibalaseleyo yokuxhoma. I-HPMC isetyenziswa njenge-thickener ye-eye drops, kunye nomxholo we-0.45% ukuya kwi-1.0%.

Iselulosi yeHydroxypropyl:

I-Hydroxypropyl cellulose (HPC) yi-cellulose enye ye-ether engeyiyo-ionic eyenziwe ngekotoni kunye nemithi ngokusebenzisa i-alkalization kunye ne-propylene oxide etherification. I-HPC idla ngokunyibilika emanzini angaphantsi kwe-40 ° C kunye nenani elikhulu le-solvents ye-polar, kwaye ukusebenza kwayo kuhambelana nomxholo weqela le-hydroxypropyl kunye neqondo le-polymerization. I-HPC inokuhambelana namachiza ahlukeneyo kwaye ine-inetia elungileyo.

I-cellulose ye-hydroxypropyl ephantsi endaweni (L-HPC) isetyenziswa kakhulu njenge-tablet disintegrant kunye ne-binder. -I-HPC inokuphucula ubunzima kunye nokukhanya kwethebhulethi, kwaye inokwenza ukuba ithebhulethi idibanise ngokukhawuleza, iphucule umgangatho wangaphakathi wethebhulethi, kwaye iphucule umphumo wonyango.

I-cellulose ye-hydroxypropyl (i-H-HPC) efakwe endaweni ephezulu kakhulu ingasetyenziswa njenge-binder yamacwecwe, iigranules, kunye ne-fine granules kwintsimi yamachiza. I-H-HPC ineempawu ezintle kakhulu zokwenza ifilimu, kwaye ifilimu efunyenweyo inzima kwaye i-elastic, enokuthelekiswa ne-plasticizers. Ukusebenza kwefilimu kunokuphuculwa ngakumbi ngokuxutywa kunye nezinye ii-agent zokunqanda ukugquma, kwaye zihlala zisetyenziselwa njengento yokugqoka ifilimu kwiipilisi. I-H-HPC inokusetyenziswa njengesixhobo se-matrix ukulungiselela iipilisi ezikhutshwa ngokuqhubekayo ze-matrix, iipellets ezikhutshwa ngokuqhubekayo kunye neepilisi zokukhululwa okuphindwe kabini.

Iselulosi yeHydroxyethyl

I-Hydroxyethyl cellulose (HEC) yi-cellulose enye ye-ether engeyo-ionic eyenziwe kwikotoni kunye nemithi ngokusebenzisa i-alkalization kunye ne-etherification ye-ethylene oxide. Kwintsimi yeyeza, i-HEC isetyenziswa kakhulu njenge-thickener, i-agent ekhuselayo ye-colloidal, i-adhesive, dispersant, stabilizer, i-agent yokumisa, i-agent-forming agent kunye ne-release-release material, kwaye ingasetyenziselwa kwi-emulsions ye-topical, i-ointments, i-eye drops. Ulwelo lomlomo, ithebhulethi eqinileyo, i-capsule kunye nezinye iifom zedosi. I-Hydroxyethyl cellulose irekhodwe kwi-US Pharmacopoeia / i-US National Formulary kunye ne-European Pharmacopoeia.

Ethyl cellulose:

I-Ethyl cellulose (EC) yenye yezona zinto zisetyenziswa kakhulu kwi-cellulose engenamanzi. I-EC ayinayo ityhefu, izinzileyo, ayinyibiliki emanzini, i-asidi okanye isisombululo se-alkali, kwaye i-soluble kwii-solvents eziphilayo ezifana ne-ethanol kunye ne-methanol. I-solvent esetyenziswa ngokuqhelekileyo yi-toluene/ethanol njenge-4/1 (ubunzima) i-solvent exutyiweyo. I-EC inosetyenziso oluninzi kumalungiselelo okukhutshwa okuzinzileyo kweziyobisi, asetyenziswa ngokubanzi njengabathwali, ii-microcapsules, kunye nokugquma izinto zokwenza ifilim ukulungiselela ukukhutshwa okuzinzileyo, okufana nezithinteli zethebhulethi, izinto zokuncamathelisa, kunye nezixhobo zokugquma ifilimu, esetyenziswa njengefilimu ye-matrix ukulungiselela. iintlobo ezahlukeneyo zeepilisi ezikhutshwa ngokuzinzileyo ze-matrix, ezisetyenziswa njengezinto ezixubeneyo ukulungiselela amalungiselelo okukhutshwa okuzinzileyo, iipellets ezizinzileyo, kwaye zisetyenziswe njengezinto ezincedisayo ze-encapsulation ukulungiselela ukukhutshwa okuzinzileyo kwe-microcapsules; inokusetyenziswa ngokubanzi njengento yokuthwala Ukulungiselela ukusabalalisa okuqinileyo; isetyenziswe ngokubanzi kwithekhnoloji yamachiza njengento yokwenza ifilimu kunye nokukhusela okukhuselekileyo, kunye ne-binder kunye ne-filler. Njengokhuselo olukhuselayo lwethebhulethi, inokunciphisa uvakalelo lwethebhulethi kumswakama kwaye ithintele iyeza ukuba lingachaphazeleki ngumswakama, ukubola kunye nokuwohloka; inokwenza ijeli ekhupha kancinci, i-microencapsulate i-polymer, kwaye ivumele ukukhululwa okuqhubekayo kwesiphumo sechiza.