Pharma grade HPMC esetyenziselwa ukutyabeka tablet

I-Hydroxypropyl Methylcellulose (HPMC) yipolymer esekelwe kwi-cellulose ye-pharmaceutical esetyenziswa ngokubanzi kumashishini amayeza njenge-ejenti yokugqoka i-tablet. I-HPMC ithathwe kwiselulosi yendalo kwaye iyaziwa ngeempawu zayo ezizodwa, njengokukwazi kwayo ukuphucula uzinzo, inkangeleko, kunye nokusebenza ngokubanzi kweemveliso zamayeza.

Kushishino lwamayeza, i-HPMC isetyenziswa njenge-arhente yokugquma kwiifom zedosi yomlomo eqinileyo, njengeepilisi kunye neepilisi. I-HPMC ingasetyenziselwa ukubonelela ngeziphumo ezahlukeneyo zokugquma, ezifana neengubo zokukhutshwa ezilawulwayo, iingubo ze-enteric, kunye neengubo zefilimu.

Ukukhutshwa okulawulwayo kweengubo kunceda ukulawula izinga apho isithako seyeza esisebenzayo (API) sikhutshwa kwigazi lesigulane, siqinisekisa ukuba umthamo ochanekileyo uhanjiswa kwixesha elide. Oku kunokunceda ukuphucula ukusebenza kwe-API kunye nokunciphisa umngcipheko wemiphumo emibi.

Iingubo ze-Enteric zinceda ukukhusela i-API ekuphuhlisweni kwesisu esiswini, ukuqinisekisa ukuba ihanjiswe emathunjini amancinci ukuze ifakwe ngokufanelekileyo. Oku kunokunceda ukuphucula i-bioavailability ye-API kunye nokunciphisa umngcipheko wokucaphuka kwesisu.

Iingubo zefilimu zinceda ekuphuculeni ukubonakala kunye nokuphathwa kweemveliso zamachiza, okwenza kube lula ukugwinya kunye nokunciphisa umngcipheko wokukhubazeka komphezulu okanye ukungahambelani. Iingubo zefilimu ze-HPMC zikwasetyenziselwa ukufihla izinto ezingathandekiyo kunye namavumba, okwenza imveliso egqityiweyo ibe nencasa ngakumbi kwisigulana.

I-HPMC ineengenelo ezininzi ngaphezu kwezinye ii-agent zokugquma, ezifana neempawu zayo ezibalaseleyo zokwenza ifilim, ukungafihlisi okuphezulu, kunye nokuphuculwa kokumelana nokufuma, ubushushu, kunye nokukhanya. Ukongeza, i-HPMC ayinayo ityhefu, i-allergenicity ephantsi, kunye ne-biocompatible, iyenza ibe sithako esikhuselekileyo nesisebenzayo sokusetyenziswa kuluhlu olubanzi lweemveliso zamayeza.

Ukuqukumbela, i-HPMC sisixhobo sokugquma esibalulekileyo kushishino lwamayeza. Ikhono layo lokuphucula ukuzinza, ukubonakala, kunye nokusebenza ngokubanzi kweemveliso zamachiza kwenza kube yinto ebalulekileyo ekuphuhliseni umgangatho ophezulu kunye nokuthembeka kweemveliso zamachiza. Ukuguquguquka kwayo, ukusebenziseka lula, kunye neendleko-zokusebenza kwenza kube yinto ethandwa kakhulu kwizicelo ezininzi, ukusuka kwiimvavanyo zeklinikhi ezincinci ukuya kwimveliso yentengiso enkulu.