Ngaba i-HPMC iyenziwe okanye yendalo?

IHydroxypropylmethylcellulose (HPMC) yikhompawundi eguquguqukayo neguquguqukayo enezicelo kuzo zonke iindidi zamashishini. Ukuze uqonde intsingiselo yayo, umntu kufuneka ahlolisise izithako zayo, iinkqubo zokuvelisa, kunye nemvelaphi.

Izithako zeHPMC:
I-HPMC yi-semi-synthetic polymer ephuma kwi-cellulose, i-polysaccharide yendalo efumaneka kwiindonga zeeseli zezityalo. Umthombo oyintloko we-cellulose yintlama yomthi okanye i-cotton fiber. Udibaniso lwe-HPMC lubandakanya ukuguqula i-cellulose ngothotho lweempendulo zemichiza ukuze ibe yi-derivative ye-cellulose.

Imiba yokwenziwa kwemveliso ye-HPMC:
Inkqubo ye-Etherification:

Ukuveliswa kwe-HPMC kubandakanya i-etherification ye-cellulose nge-propylene oxide kunye ne-methyl chloride.
Ngethuba le nkqubo, i-hydroxypropyl kunye namaqela e-methyl angeniswa kwi-cellulose backbone, eyenza i-HPMC.

Ukuguqulwa kweekhemikhali:

Ukuguqulwa kweekhemikhali ezivezwe ngexesha lokudibanisa kukhokelela ekubeni i-HPMC ihlelwe njengekhompawundi enesiqingatha sokwenziwa.
IDegree of substitution (DS) ibhekisa kwiavareji yenani lehydroxypropyl kunye namaqela emethyl ngeyunithi yeglucose kwikhonkco leselulosi. Eli xabiso le-DS linokulungiswa ngexesha lenkqubo yokuvelisa ukufumana i-HPMC eneempawu ezithile.

Imveliso yemizi-mveliso:

I-HPMC iveliswa kwimizi-mveliso kumlinganiselo omkhulu ziinkampani ezininzi ezisebenzisa ukusabela kweekhemikhali ezilawulwayo.
Inkqubo yokuvelisa ibandakanya iimeko ezichanekileyo zokuphumeza iipropati ezifunwayo kunye nokusebenza kwemveliso yokugqibela.

Imithombo yendalo ye-HPMC:
I-cellulose njengomthombo wendalo:

I-Cellulose yinto esisiseko ye-HPMC kwaye ininzi kwindalo.
Izityalo, ngakumbi iinkuni kunye nomqhaphu, ziyimithombo etyebileyo yeselulosi. Ukutsalwa kwe-cellulose kule mithombo yendalo kuqalisa inkqubo yokwenziwa kwe-HPMC.

Ukonakala kwezinto eziphilayo:

I-HPMC i-biodegradable, ipropathi yezinto ezininzi zendalo.
Ubukho be-cellulose yendalo kwi-HPMC inegalelo kwiipropati zayo ezinokuguquguquka, iyenze ukuba ivumelane nokusingqongileyo kwizicelo ezithile.

Usetyenziso lwe-HPMC:
iyeza:

I-HPMC isetyenziswa ngokubanzi kushishino loxubo-mayeza njengee-arhente zokugquma, izibophelelo kunye ne-imatrics ekhutshwa ngokuzinzileyo kuqulunqo lwethebhulethi. I-biocompatibility yayo kunye neempawu zokukhululwa ezilawulwayo zenza ukhetho lokuqala kwiinkqubo zokuhanjiswa kweziyobisi.

Ishishini lokwakha:

Ekwakhiweni, i-HPMC isetyenziswa njenge-arhente yokugcina amanzi, i-thickener, kunye nokumisela ixesha lokulawula kwizinto ezisekelwe kwisamente. Indima yayo ekuphuculeni ukusebenza kunye nokuncamathela kodaka kunye neeplasta ibalulekile.

ishishini lokutya:

I-HPMC isetyenziswa njengento etyebisayo kunye nejeli kushishino lokutya.
Ngokuqhelekileyo isetyenziswa kwiimveliso zokutya ezifana neesosi, iisuphu kunye neempahla ezibhakiweyo.

izithambiso:

Kwizinto zokuthambisa, i-HPMC ifumaneka kwiimveliso ezahlukeneyo eziquka iikhrimu, izinto zokuthambisa, kunye neejeli, ezisebenza njengezinto ezityebileyo, izinzisi, kunye nezixubesi.

Usetyenziso lwemizimveliso:

I-HPMC's versatility inabela kwizicelo ezahlukeneyo zemizi-mveliso, kubandakanywa ukwakhiwa kwepeyinti, izinto zokuncamathelisa kunye nokulungiswa kwamalaphu.

Ubume bolawulo:
ubume be-GRAS:

EUnited States, i-HPMC yaziwa ngokubanzi njengekhuselekile (GRAS) kwizicelo ezithile ekutyeni yi-US Food and Drug Administration (FDA).

Imigangatho yeziyobisi:

I-HPMC esetyenziswa kwiimveliso zamachiza kufuneka ihambelane nemigangatho ye-pharmacopeial efana ne-United States Pharmacopeia (USP) kunye ne-European Pharmacopoeia (Ph. Eur.).

ukuququmbela:
Isishwankathelo, i-hydroxypropyl methylcellulose (HPMC) i-polymer ye-semi-synthetic ephuma kwi-cellulose yendalo ngokusebenzisa inkqubo yokuguqulwa kwemichiza elawulwayo. Nangona iye yenzeka inguqu ebalulekileyo eyenziweyo, imvelaphi yayo ilele kwimithombo yendalo efana nentlaka yomthi kunye nomqhaphu. Iimpawu ezizodwa ze-HPMC ziyenza ibe yikhompawundi enexabiso esetyenziswa kakhulu kumayeza, ulwakhiwo, ukutya, izithambiso kunye namashishini ahlukeneyo. Ukudityaniswa kwe-cellulose yendalo kunye nokuguqulwa kokwenziwa kunegalelo ekusetyenzisweni kwayo, ukubola kwe-biodegradability kunye nokwamkelwa kokulawula kwiinkalo ezahlukeneyo.