Ngaba i-HPMC yihydrogel?

IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa ngeendlela ezahlukeneyo kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa. Nangona ingasetyenziselwa ukwenza i-hydrogels phantsi kweemeko ezithile, ayisiyiyo i-hydrogel ngokwayo.

1. Intshayelelo kwi-HPMC:

IHydroxypropyl methylcellulose (HPMC) yi-semi-synthetic polymer ephuma kwi-cellulose, ipholima yendalo efumaneka kwiindonga zeeseli zezityalo. Yenziwa ngokuphatha i-cellulose nge-alkali kwaye emva koko iphendule ngepropylene oxide kunye ne-methyl chloride. Ipolymer enesiphumo ibonisa uluhlu lweepropathi ezenza ukuba zixabiseke kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa kunye nokwakha.

2. Iipropati ze-HPMC:

I-HPMC ineempawu ezininzi eziluncedo:

a. Ukunyibilika kwamanzi:

I-HPMC iyanyibilika emanzini, yenze izisombululo ze-viscous. Le propati iluncedo ngokukodwa kumayeza, apho ingasetyenziselwa ukudala ukumiswa, i-emulsions, kunye nokulawulwa kokukhutshwa kweyeza.

b. Isakhono sokwenza ifilim:

I-HPMC inokwenza iifilimu eziguquguqukayo nezingafihliyo xa iphoswe kwizisombululo zayo ezinamanzi. Ezi filimu zifumana usetyenziso kwiingubo zeetafile, ii-capsules, kunye neefilimu zomlomo.

c. Isilungisi seRheology:

I-HPMC isebenza njenge-thickener kunye ne-rheology modifier kwizisombululo ezinamanzi. I-viscosity yayo inokulungelelaniswa ngokulungelelanisa izinto ezifana nobunzima be-molecular kunye neqondo lokuthatha indawo.

d. Biocompatibility:

I-HPMC i-biocompatible kwaye ayinayo ityhefu, iyenza ilungele ukusetyenziswa kumayeza, izithambiso, kunye neemveliso zokutya.

3. Usetyenziso lwe-HPMC:

I-HPMC ifumana izicelo ezixhaphakileyo kuwo wonke amashishini ahlukeneyo:

a. Amachiza:

Kuqulunqo lwamayeza, i-HPMC isetyenziswa njenge-binder, i-disintegrant, i-agent-coating agent, kunye ne-matrix yokukhululwa okuqhubekayo. Iphucula ingqibelelo yethebhulethi, ilawula i-kinetics yokukhululwa kweziyobisi, kwaye iphucula ukuthotyelwa kwesigulane.

b. Ishishini lokutya:

Kushishino lokutya, i-HPMC iqeshwe njenge-thickener, emulsifier, stabilizer, kunye ne-gelling agent. Inegalelo kuthungelwano, i-viscosity, kunye nokuzinza kweemveliso zokutya ezifana neesosi, izinxibo, kunye nezimuncumuncu.

c. Izithambiso:

I-HPMC isetyenziswa kwizinto zokuthambisa kunye neemveliso zokhathalelo lobuqu njenge-thickener, i-arhente exhomayo, ifilimu yangaphambili, kunye ne-emulsifier. Inika iipropathi ezinqwenelekayo ze-rheological kwiikhrimu, izinto zokuthambisa, kunye neejeli ngelixa zikhulisa uzinzo kunye neempawu zoluvo.

d. Ulwakhiwo:

Kushishino lokwakha, i-HPMC isetyenziswa kwimathiriyeli yesamente njenge-arhente yokugcina amanzi, isixhasi sokusebenza, kunye ne-arhente yokujiya. Iphucula udaka kunye neempawu ze-plaster, ezifana nokunamathela, ukudibanisa, kunye nokuxhathisa i-sag.

4. Ukwenziwa kweHydrogel kunye ne-HPMC:

Nangona i-HPMC ngokwayo ayiyona i-hydrogel, inokuthatha inxaxheba ekubunjweni kwe-hydrogel phantsi kweemeko ezifanelekileyo. I-hydrogel yinethiwekhi yamakhonkco e-polymer ekwazi ukufunxa kunye nokugcina amanzi amaninzi. Ukwenziwa kwee-hydrogels ze-HPMC ngokuqhelekileyo kubandakanya ukunqumla amatyathanga epolymer ukwenza inethiwekhi ene-dimensional-dimensional ekwaziyo ukufunxa amanzi.

a. Iiarhente ezidibanisayo:

Ii-agent ezidibanisayo ezifana ne-glutaraldehyde, i-genipin, okanye iindlela zomzimba ezifana ne-freeze-nying cycle zingaqeshwa ukuwela amatyathanga e-HPMC. Oku kunqunyulwa kweziphumo ekwenziweni kwenethiwekhi ye-hydrogel ngaphakathi kwe-matrix ye-HPMC.

b. Ukudumba:

Iimpawu ze-hydrogel ze-HPMC zinokulungelelaniswa ngokuhlengahlengisa izinto ezifana neqondo lokutshintshela, ubunzima bemolekyuli, kunye nokuxinana kokudibanisa. Amanqanaba aphezulu okutshintsha kunye nobunzima beemolekyuli ngokubanzi bukhokelela ekwandeni kwe-hydrogel amandla okudumba.

c. Ukusetyenziswa kwe-HPMC Hydrogels:

I-HPMC hydrogels ifumana izicelo ekuhanjisweni kweziyobisi, ukuphiliswa kwenxeba, ubunjineli beethishu, kunye neelensi zoqhagamshelwano. I-biocompatibility yabo, iipropathi ezinokutshibilika, kunye nokukwazi ukugcina amanzi kubenza bafaneleke kwizicelo ezahlukeneyo ze-biomedical.

I-HPMC yipolymer eguquguqukayo enezicelo ezahlukeneyo kuwo wonke amayeza, ukutya, izinto zokuthambisa, kunye namashishini okwakha. Ngelixa ingeyiyo i-hydrogel ngokwendalo, inokuthatha inxaxheba ekwenziweni kwe-hydrogel ngokudibanisa amakhonkco ayo epolymer. Iziphumo ze-HPMC ze-hydrogels zibonisa iipropati ezifana nokufunxa kwamanzi kunye nokugcinwa, okwenza ukuba zixabiseke kwizicelo ze-biomedical. Njengoko uphando luqhubeka nokuphonononga ukusetyenziswa kwenoveli kunye noyilo lwe-HPMC, ukubaluleka kwayo kumashishini ahlukeneyo kulindeleke ukuba kwandiswe ngakumbi.