Izakhiwo ezongeziweyo IHydroxypropyl Methylcellulose Amanzi Abandayo Anyityilisiweyo

IHydroxypropyl methylcellulose (HPMC) yi-semi-synthetic, ipholima enyibilikayo emanzini eyenziwe ngeselulosi. Isetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, ukutya, izinto zokuthambisa, kunye nokwakha ngenxa yeempawu zayo ezibalaseleyo, kubandakanya isakhono esihle sokwenza ifilim, ukujiya, ukubopha, kunye nokugcinwa kwamanzi.

Enye yezona mpawu zibalulekileyo ze-HPMC kukukwazi kwayo ukunyibilika emanzini abandayo, nto leyo eyenza kube ukhetho oludumileyo kwizicelo ezifuna inkqubo yokupheliswa ekhawulezayo nelula. Kweli nqaku, siza kuphonononga iimpawu ze-HPMC, iindlela zokunyibilika kwamanzi abandayo, kunye nokusetyenziswa kwayo.

Iipropati zeHydroxypropyl Methylcellulose

I-HPMC ngumgubo omhlophe ukuya kumhlophe ongenavumba, ongenancasa, kwaye awunayo ityhefu. Inozinzo oluhle lwe-thermal kwaye inokumelana noluhlu olubanzi lwamaxabiso e-pH. I-HPMC iyanyibilika emanzini kwaye yenza izisombululo ezicacileyo, ezine-viscous ezine-acidic kancinane pH.

Iimpawu zomzimba kunye neekhemikhali ze-HPMC zinokutshintshwa ngokutshintsha iqondo layo lokuthatha indawo (DS) kunye nobunzima bayo bemolekyuli. I-DS ibhekisa kwinani lamaqela e-hydroxyl kwimolekyuli ye-cellulose athi afakwe endaweni yeqela le-methyl okanye le-hydroxypropyl. Xa iphezulu i-DS, inani elikhulu lamaqela atshintshiweyo, okukhokelela kubunzima obuphantsi bemolekyuli kunye nokunyibilika okuphezulu kwamanzi.

Ubunzima bemolekyuli ye-HPMC inokuchaphazela ukunyibilika kwayo, i-viscosity, kunye neempawu ze-gelation. Ubunzima bemolekyuli ephezulu HPMC ithande ukuba ne-viscosity ephezulu kunye namandla ejeli, ngelixa ubunzima obuphantsi bemolekyuli HPMC inonyibiliko olungcono kumanzi abandayo.

Iinkqubo zokunyibilika kwamanzi abandayo

Ukunyibilika kwamanzi abandayo kwe-HPMC kubalelwa ikakhulu kwiindlela ezimbini: i-hydrogen bonding kunye ne-steric hindrance.

Ukudityaniswa kweHydrojeni kwenzeka xa amaqela e-hydroxyl kwimolekyuli ye-HPMC edibana neemolekyuli zamanzi ngeebhondi ze-hydrogen. Amaqela e-hydroxypropyl kunye ne-methyl kwi-HPMC nawo angathatha inxaxheba kwi-hydrogen bonding kunye neemolekyuli zamanzi, ephucula ngakumbi ukunyibilika.

Uthintelo lwesteric lubhekisa ekuthinteleni ngokwasemzimbeni amatyathanga ecellulose ngamaqela amakhulu e-hydroxypropyl kunye ne-methyl. Isithintelo se-steric sithintela ii-molecule ze-HPMC ekubeni zenze intsebenziswano eqinile ye-intermolecular, okukhokelela ekuphuculeni ukunyibilika kwamanzi.

Ukusetyenziswa kweHydroxypropyl Methylcellulose

I-HPMC isetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeepropati zayo ezibalaseleyo. Nazi ezinye zezicelo zayo:

Amachiza: I-HPMC iqhele ukusetyenziswa njenge-binder, i-disintegrant, kunye ne-ejenti yokwenza ifilimu kwiipilisi kunye nee-capsules zamachiza. Ikwasetyenziswa njenge-thickener kunye ne-stabilizer kwi-ophthalmic formulations kunye neempumlo.

Ukutya: I-HPMC isetyenziswa njenge-thickener, emulsifier, kunye ne-stabilizer kwiimveliso zokutya ezahlukeneyo ezifana ne-ayisikrimu, iyogathi, kunye nezinxibo zesaladi. Ikwasetyenziswa njengesixhobo sokugquma iziqhamo kunye nemifuno ukuphucula inkangeleko yazo kunye nobomi beshelufu.

Izithambiso: I-HPMC isetyenziswa njenge-thickener, i-emulsifier, kunye ne-ejenti yokwenza ifilim kwizithambiso kunye neemveliso zokhathalelo lomntu ezifana neloshini, iishampu, kunye ne-conditioner.

Ulwakhiwo: I-HPMC isetyenziswa njenge-arhente yokugcina amanzi, i-thickener, kunye ne-binder kwizinto zesamente ezifana nodaka kunye nodaka. Iphucula ukusebenza kakuhle, inciphisa ukuqhekeka, kwaye yongeza ukunamathela.

Ezinye izicelo: I-HPMC ikwasetyenziswa kwezinye izinto ezahlukeneyo ezifana noshicilelo olulukiweyo, iipeyinti kunye nokwakheka kokugquma, nee-inki.