IHydroxypropyl methyl cellulose (HPMC) isetyenziswa ngokubanzi kwaye isetyenziswa ngokubanzi i-non-ionic cellulose ether, ehlala isetyenziswa kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa. Iimpawu eziphambili zobugcisa ze-HPMC zinokuhlelwa ngokubanzi zibe ziipropati zomzimba, iikhemikhali, kunye nokusebenza, nganye inegalelo ekulungelweni kwayo kwizicelo ezithile.
1. IiPropati zoMzimba
a. Imbonakalo
I-HPMC idla ngokuba ngumgubo omhlophe ukuya komhlophe, ongenavumba kwaye awunancasa, nto leyo ebonisa ubunyulu kunye nokufaneleka kwayo ukusetyenziswa kwizicelo ezinovakalelo ezifana namayeza kunye nokutya.
b. Ubungakanani beNcam
Ubungakanani bamasuntswana e-HPMC bunokuchaphazela ukunyibilika kwayo kunye ne-dispersibility emanzini okanye kwezinye izinyibilikisi. Ifumaneka ngokwesiqhelo kumabakala ahlukeneyo, apho ubungakanani bokuhanjiswa kobungakanani bamasuntswana busuka kwicolekileyo ukuya kumgubo orhabaxa. Ubungakanani bamasuntswana acolekileyo bukholisa ukukhokelela kumazinga okupheliswa okukhawulezayo.
c. Unizi lolwapho kuyiwa khona
Ukuxinana ngobuninzi sisalathisi esibalulekileyo, ingakumbi kwiinjongo zokuphatha kunye nokucubungula. Ngokuqhelekileyo iqala ukusuka kwi-0.25 ukuya kwi-0.70 g/cm³, echaphazela iimpawu zokuhamba kwezinto kunye neemfuno zokupakisha.
d. Umxholo wokufuma
Isiqulatho sokufuma kwi-HPMC kufuneka sibencinci ukuqinisekisa uzinzo kunye nokuthintela ukufumba ngexesha lokugcinwa. Isiqulatho sokufuma esisemgangathweni sikholisa ukuba ngaphantsi kwe-5%, amaxesha amaninzi malunga ne-2-3%.
2. Iipropati zeMichiza
a. IMethoxy kunye neHydroxypropyl Content
Amanqanaba okutshintshwa kwe-methoxy (-OCH₃) kunye ne-hydroxypropyl (-OCH₂CH₂OH) amaqela zizibonakaliso zemichiza ebalulekileyo, ezichaphazela ukunyibilika, ukushisa kwe-gelation, kunye ne-viscosity ye-HPMC. Umxholo we-methoxy oqhelekileyo uvela kwi-19-30%, kunye nomxholo we-hydroxypropyl ukusuka kwi-4-12%.
b. Viscosity
I-Viscosity yenye yezona zinto zibalulekileyo, ezichaza ukusebenza kwe-HPMC kwizicelo. Ilinganiswa kwizisombululo ezinamanzi, ngokuqhelekileyo kusetyenziswa i-viscometer ejikelezayo. I-Viscosity inokuqala ukusuka kwi-centipoises (cP) ukuya kwi-100,000 cP. Olu luhlu olubanzi luvumela ukulungelelaniswa kweenkqubo ezahlukeneyo zoshishino.
c. Ixabiso le-pH
I-pH yesisombululo se-2% se-HPMC ngokuqhelekileyo iwela phakathi kwe-5.0 kunye ne-8.0. Oku kungathathi hlangothi kubalulekile ekusebenzisaneni kwimixube, ngakumbi kumayeza kunye neemveliso zokutya.
d. Ubunyulu noKungacoceki
Ucoceko oluphezulu luyimfuneko, ngakumbi ekutyeni nakumabanga amayeza. Ukungcola okufana neentsimbi ezinzima (umzekelo, ilothe, iarsenic) kufuneka kuncinci. Iinkcukacha zihlala zifuna iintsimbi ezinzima ukuba zibe ngaphantsi kwe-20 ppm.
3. IiPropati eziSebenzayo
a. Ukunyibilika
I-HPMC iyanyibilika kumanzi abandayo kunye nashushu, yenza izisombululo ezicacileyo okanye ezinobumdaka obuncinci. Oku kunyibilika kabini kunenzuzo kwimixube eyahlukeneyo, ukuvumela ukuguquguquka kwiimeko zokucubungula.
b. I-Thermal Gelation
Ipropathi eyodwa ye-HPMC kukukwazi ukwenza iijeli xa kufudumeza. Ukushisa kwe-gelation kuxhomekeke kwinqanaba lokutshintshwa kunye nokugxininiswa. Amaqondo obushushu aqhelekileyo asuka kuma-50°C ukuya kuma-90°C. Le propati isetyenziswa kwizicelo ezifana nemixube ekhutshiweyo elawulwayo kumayeza.
c. Ukukwazi ukwenza ifilimu
I-HPMC inokwenza iifilimu ezomeleleyo, eziguquguqukayo, neziselubala. Le propathi isetyenziswa ngokubanzi kwi-coatings, i-encapsulation yamayeza, kunye ne-glazing yokutya.
d. Umsebenzi womphezulu
I-HPMC ibonisa iipropati ezisebenza phezulu, ibonelela nge-emulsification kunye nemiphumo yokuzinzisa. Oku kuluncedo ngakumbi kwizinto zokuthambisa, amayeza, kunye namashishini okutya apho kufuneka i-emulsions ezinzileyo.
e. Ukugcinwa kwamanzi
Enye yeempawu ze-HPMC kukwazi ukugcina amanzi. Isebenza kakhulu ekugcineni ukufuma, okubalulekileyo kwizicelo ezinje ngodaka, iiplaster, kunye nezithambiso.
4. Izicelo ezithe ngqo kunye neeMfuno zazo
a. Amachiza
Kumashishini amayeza, i-HPMC isetyenziswa njenge-binder, ifilimu-yangaphambili, kunye ne-agent-release-release agent. Iimpawu zobuchwephesha ezifana nokucoceka okuphezulu, amabakala athile e-viscosity, kunye namanqanaba achanekileyo okutshintshwa kubalulekile ukuqinisekisa ukusebenza kunye nokhuseleko kwiinkqubo zokuhanjiswa kweziyobisi.
b. Ukwakhiwa
Ekwakhiweni, ngakumbi kwiimveliso ezisekelwe kwisamente kunye ne-gypsum, i-HPMC isetyenziselwa ukuphucula ukusebenza, ukugcinwa kwamanzi kunye nokubambelela. Apha, i-viscosity, ubungakanani bamasuntswana, kunye neempawu zokugcina amanzi zibalulekile.
c. Ishishini lokutya
I-HPMC iqeshwe njenge-thickener, emulsifier, kunye ne-stabilizer kwiimveliso ezahlukeneyo zokutya. Ukusetyenziswa kokutya, izalathi zomdla ziquka ukucoceka okuphezulu, ukungabi nabutyhefu, kunye neeprofayili ezithile ze-viscosity ukuqinisekisa ukuthungwa okuhambelanayo kunye nokuzinza.
d. Ukhathalelo loBuqu kunye neZithambiso
Kwiimveliso zokhathalelo lomntu, i-HPMC ixabiswa ngenxa yokuqina kwayo, i-emulsifying, kunye neempawu zokwenza ifilimu. Iimpawu ezibalulekileyo ziquka ukunyibilika, i-viscosity, kunye nokuhlanzeka, ukuqinisekisa ukuhambelana nezinye izithako kunye nokuzinza kwemveliso yokugqibela.
5. ULawulo loMgangatho kunye neendlela zoVavanyo
Ulawulo lomgangatho we-HPMC lubandakanya uvavanyo olungqongqo lweempawu zayo zomzimba nezekhemikhali. Iindlela zovavanyo eziqhelekileyo ezisetyenziswayo ziquka:
a. Umlinganiselo weViscosity
Ukusebenzisa i-viscometers ejikelezayo ukumisela i-viscosity yezisombululo ze-HPMC.
b. Uhlalutyo lokuTshintsha
Iindlela ezifana ne-NMR spectroscopy zisetyenziselwa ukumisela i-methoxy kunye nomxholo we-hydroxypropyl.
c. Ukumiselwa koMxholo wokufuma
Karl Fischer titration okanye ilahleko ekomisweni (LOD) iindlela zisetyenziswa.
d. Uhlalutyo lobungakanani beNcam
I-Laser diffraction kunye neendlela ze-sieving zokuqinisekisa ukusabalalisa ubungakanani bamasuntswana.
e. Umlinganiselo we-pH
Imitha ye-pH isetyenziselwa ukulinganisa i-pH yezisombululo ze-HPMC ukuqinisekisa ukuba ziwela phakathi koluhlu oluchaziweyo.
f. Uvavanyo lweNtsimbi enzima
I-atomic absorption spectroscopy (AAS) okanye i-inductively coupled plasma (ICP) uhlalutyo lokukhangela ukungcola kwesinyithi.
I-Hydroxypropyl methyl cellulose (HPMC) sisongezo esisebenza ngezinto ezininzi ezinoluhlu olubanzi lwezicelo, ezifuna ukuqondwa ngokubanzi kwezalathi zayo zobugcisa. Iimpawu ezibonakalayo ezinje ngenkangeleko, ubungakanani bamasuntswana, ukuxinana kwesambuku, kunye nomxholo wokufuma ziqinisekisa ukuphathwa ngokufanelekileyo kunye nokulungiswa. Iipropati zeMichiza ezibandakanya i-methoxy kunye ne-hydroxypropyl umxholo, i-viscosity, i-pH, kunye nococeko luchaza ukufaneleka kwayo kwizicelo ezithile. Iipropati ezisebenzayo ezifana nokunyibilika, i-thermal gelation, isakhono sokwenza ifilimu, umsebenzi ongaphezulu, kunye nokugcinwa kwamanzi kugxininisa ngakumbi ukuguquguquka kwayo. Ngokubambelela kumanyathelo angqongqo olawulo lomgangatho, i-HPMC inokusetyenziswa ngempumelelo kuwo wonke amashishini ahlukeneyo, izalisekisa imisebenzi eyahlukeneyo ukusuka kumayeza ukuya kulwakhiwo.
Ixesha lokuposa: May-22-2024