IHydroxypropyl methylcellulose HPMC luhlobo lwe-non-ionic cellulose exutywe ne-ether. Yahlukile kwi-ionic methyl carboxymethyl cellulose exutywe ne-ether, ayisebenzi ngesinyithi esinzima. Ngenxa yemilinganiselo eyahlukeneyo yomxholo we-methoxyl kunye nomxholo we-hydroxypropyl kwi-hydroxypropyl methylcellulose kunye ne-viscosities eyahlukeneyo, kukho iindidi ezininzi ezineempawu ezahlukeneyo, umzekelo, umxholo ophezulu we-methoxyl kunye nomxholo ophantsi we-hydroxypropyl Ukusebenza kwayo kusondele kuleyo ye-methyl cellulose, ngelixa ukusebenza Umxholo ophantsi we-methoxy kunye nomxholo ophezulu we-hydroxypropyl usondele kulowo we-hydroxypropyl methyl cellulose. Nangona kunjalo, kuluhlu ngalunye, nangona kuphela inani elincinci leqela le-hydroxypropyl okanye inani elincinci leqela le-methoxyl liqulethwe, ukunyibilika kwi-solvents yezinto eziphilayo okanye ubushushu be-flocculation kwisisombululo samanzi sahluke kakhulu.
1. Ukunyibilika kwe-hydroxypropyl methylcellulose
①Ukunyibilika kwe-hydroxypropyl methylcellulose emanzini I-Hydroxypropyl methylcellulose eneneni luhlobo lwe-methylcellulose elungiswe yi-propylene oxide (methoxypropylene), ngoko ke iseneempawu ezifanayo njenge-methyl cellulose I-Cellulose ineempawu ezifanayo zokunyibilika kwamanzi abandayo kunye nokunganyibiliki kwamanzi ashushu. Nangona kunjalo, ngenxa yeqela le-hydroxypropyl elungisiweyo, ubushushu bayo be-gelation emanzini ashushu buphezulu kakhulu kune-methyl cellulose. Umzekelo, i-viscosity ye-hydroxypropyl methylcellulose isisombululo se-aqueous kunye ne-2% ye-methoxy content substitution degree DS=0.73 kunye nomxholo we-hydroxypropyl MS=0.46 yimveliso ye-500 mpa? C, ngelixa i-methyl cellulose kubushushu obufanayo bumalunga nama-55°C kuphela. Ngokuphathelele ukuchithwa kwayo emanzini, kuye kwaphuculwa kakhulu. Umzekelo, i-pulverized hydroxypropyl methylcellulose (imveliso enobungakanani besuntswana le-0.2 ~ 0.5mm kunye ne-4% ye-aqueous viscosity ye-2pa?s kwi-20 ° C inokuthengwa Kwiqondo lokushisa, i-soluble lula emanzini ngaphandle kokupholisa. .
②Ukunyibilika kwe-hydroxypropyl methylcellulose kwizinyibilikisi ze-organic Ukunyibilika kwe-hydroxypropyl methylcellulose kwizinyibilikisi ze-organic nakho kungcono kune-methylcellulose. Kwiimveliso ezingaphezulu kwe-2.1,i-high-viscosity hydroxypropyl methylcelluloseequlethe i-hydroxypropyl MS = 1.5 ~ 1.8 kunye ne-methoxy DS = 0.2 ~ 1.0, kunye neqondo elipheleleyo lokutshintshwa ngaphezu kwe-1.8, i-soluble kwi-anhydrous methanol kunye ne-ethanol solutions Medium, kunye ne-thermoplastic kunye ne-soluble yamanzi. Ikwanyibilika kwiihydrocarbon eziklorini ezifana ne-methylene chloride kunye ne-chloroform, kunye ne-solvents eziphilayo ezifana ne-acetone, isopropanol kunye ne-diacetone alcohol. Ukunyibilika kwayo kwizinyibilikisi zendalo kubhetele kunonyibiliko lwamanzi.
2. Izinto ezichaphazela i-viscosity ye-hydroxypropyl methylcellulose
Izinto Eziphembelela i-Viscosity ye-Hydroxypropyl Methyl Cellulose Ukumiselwa kwe-viscosity esemgangathweni ye-hydroxypropyl methyl cellulose iyafana neyezinye ii-cellulose ethers. Ilinganiswa kwi-20 ° C kunye ne-2% yesisombululo esimanzi njengomgangatho. I-viscosity yemveliso efanayo iyanda ngokunyuka koxinzelelo. Kwiimveliso ezinobunzima obuhlukeneyo beemolekyuli kwinqanaba elifanayo, imveliso enobunzima obukhulu be-molecular ine-viscosity ephezulu. Ubudlelwane bayo kunye nobushushu bufana ne-methyl cellulose. Xa iqondo lokushisa liphakama, i-viscosity iqala ukuhla, kodwa xa ifikelela kwiqondo lokushisa elithile, i-viscosity iphakama ngokukhawuleza kwaye i-gelation iyenzeka. Ubushushu be-gel yeemveliso ezisezantsi ze-viscosity ziphezulu. iphezulu. I-gel point yayo ayihambelani kuphela ne-viscosity ye-ether, kodwa ihambelana nomlinganiselo wokubunjwa kweqela le-methoxyl kunye neqela le-hydroxypropyl kwi-ether kunye nobukhulu be-degree substitution degree. Kufuneka kuqatshelwe ukuba i-hydroxypropyl methylcellulose nayo i-pseudoplastic, kwaye isisombululo sayo sizinzile kwiqondo lokushisa ngaphandle kokuthotywa kwe-viscosity ngaphandle kokuba kunokwenzeka ukuchithwa kwe-enzymatic.
3. I-Hydroxypropyl methylcellulose ixhathisa i-asidi kunye ne-alkali
I-Hydroxypropyl methylcellulose acid kunye nokumelana ne-alkali I-Hydroxypropyl methylcellulose ngokuqhelekileyo izinzile kwi-acids kunye ne-alkali, kwaye ayichaphazeleki kuluhlu lwe-pH 2 ~ 12. Iyakwazi ukumelana nomlinganiselo othile we-asidi yokukhanya, Njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njl. I-alkalis ezifana ne-caustic soda, i-caustic potash kunye namanzi ekalika ayinamphumo kuyo, kodwa inokunyusa kancinane i-viscosity yesisombululo, kwaye iyancipha ngokukhawuleza.
4. Ukungahambi kakuhle kwe-hydroxypropyl methylcellulose
I-Miscibility ye-hydroxypropyl methylcellulose isisombululo se-Hydroxypropyl methylcellulose sinokuxutywa kunye neekhompawundi ze-polymer ezinyibilikayo emanzini ukuze zibe yinto efanayo kunye nesisombululo esicacileyo kunye ne-viscosity ephezulu. Ezi zixhobo ze-polymer ziquka i-polyethylene glycol, i-polyvinyl acetate, i-polysilicone, i-polymethylvinylsiloxane, i-hydroxyethyl cellulose, kunye ne-methyl cellulose. Iikhompawundi zendalo eziphezulu zemolekyuli ezifana nentlaka ye-arabic, itshungama yembotyi yeenkumbi, i-karaya gum, njl. IHydroxypropyl methylcellulose ingaxutywa nemannitol ester okanye isorbitol ester ye stearic acid okanye palmitic acid, kwaye ingaxutywa ne glycerin, sorbitol kunye ne mannitol, kwaye ezi khompawundi zingasetyenziswa njenge hydroxypropyl methylcellulose Plasticizer ye cellulose.
5. I-Insolubilization kunye ne-solubility yamanzi ye-hydroxypropyl methylcellulose
I-ethers ye-cellulose e-soluble yamanzi e-soluble ethers ye-hydroxypropyl methylcellulose inokudibaniswa kunye ne-aldehydes phezu komhlaba, ukwenzela ukuba ezi zi-ethers ze-soluble zamanzi zixutywe kwisisombululo kwaye zingabi namanzi. I-aldehydes eyenza i-hydroxypropyl methylcellulose i-insoluble iquka i-formaldehyde, i-glyoxal, i-succinic aldehyde, i-adipaldehyde, njl njl. Xa usebenzisa i-formaldehyde, ingqalelo ekhethekileyo kufuneka ihlawulwe kwixabiso le-pH yesisombululo, phakathi kwayo i-glyoxal isabela ngokukhawuleza, ngoko i-glyoxal isetyenziswa ngokuqhelekileyo njenge-crosslink. arhente kwimveliso yoshishino. Isixa solu hlobo lwe-agent edibeneyo kwisisombululo ngu-0.2% ~ 10% yobunzima be-ether, ngokukhethekileyo i-7% ~ 10%, umzekelo, i-3.3% ~ 6% ye-glyoxal iyona ifanelekileyo. Ubushushu bonyango jikelele ngu-0 ~ 30℃, kwaye ixesha yi-1 ~ 120min. Ukusabela kwe-cross-linking kufuneka kuqhutywe phantsi kweemeko ze-acidic. Ngokubanzi, isisombululo songezwa kuqala nge-asidi eyomeleleyo ye-inorganic okanye i-organic carboxylic acid ukunyenyisa i-pH yesisombululo malunga ne-2 ~ 6, ngokukodwa phakathi kwe-4 ~ 6, kwaye emva koko wongeze i-aldehydes ukwenza i-cross-linking reaction. I-asidi esetyenzisiweyo ine-asidi ye-hydrochloric, i-asidi ye-sulfuric, i-asidi ye-phosphoric, i-asidi ye-fomic, i-acetic acid, i-hydroxyacetic acid, i-succinic acid okanye i-citric acid njl., apho i-formic acid okanye i-acetic acid iyacetyiswa, kwaye i-asidi ye-formic ilungile. I-asidi kunye ne-aldehyde nazo zinokongezwa ngaxeshanye ukuvumela isisombululo ukuba singene kwi-reaction cross-linking reaction ngaphakathi koluhlu olufunwayo lwe-pH. Le mpendulo idla ngokusetyenziswa kwinkqubo yokugqibela yokonyango kwinkqubo yokulungiselela i-cellulose ethers. Emva kokuba i-cellulose ether inganyibiliki, kukulungele ukuhlamba kunye nokucoca ngamanzi kwi-20 ~ 25 ° C. Xa imveliso isetyenziswa, izinto ze-alkali zingongezwa kwisisombululo semveliso ukulungisa i-pH yesisombululo ukuba ibe yi-alkaline, kwaye imveliso iya kuchithwa kwisisombululo ngokukhawuleza. Le ndlela iphinda isetyenziswe kunyango lwefilimu emva kokuba isisombululo se-cellulose ether senziwe kwifilimu ukuze senze ifilimu engenakunyibilika.
6. Ukumelana ne-enzyme ye-hydroxypropyl methylcellulose
Ukumelana ne-enzyme ye-hydroxypropyl methylcellulose yi-theoretically cellulose derivatives, njengeqela ngalinye le-anhydroglucose, ukuba kukho iqela elibambeleyo elibambene ngokuqinileyo, akukho lula ukusuleleka nge-microorganisms, kodwa ngokwenene imveliso egqityiweyo Xa ixabiso lokutshintsha lidlula i-1, kuya kuphinda kuthotywe nge-enzymes, oku kuthetha ukuba iqondo lokutshintshwa kweqela ngalinye kwikhonkco le-cellulose alifani ngokwaneleyo, kwaye i-microorganisms inokutshatyalaliswa kwiqela elingatshintshiyo le-anhydroglucose ukuze zenze iswekile , njengezondlo ze-microorganisms ukuba zifunxe. Ke ngoko, ukuba iqondo le-etherification endaweni yeselulosi liyenyuka, ukuchasana nokukhukuliseka kwe-enzymatic ye-cellulose ether kuya kwanda. Ngokweengxelo, phantsi kweemeko ezilawulwayo, iziphumo ze-hydrolysis ze-enzymes, i-viscosity eseleyo ye-hydroxypropyl methylcellulose (DS = 1.9) yi-13.2%, i-methylcellulose (DS = 1.83) yi-7.3%, i-methylcellulose (DS = 1.66) yi-3.8%. kunye ne-hydroxyethyl cellulose yi-1.7%. Ingabonwa ukuba i-hydroxypropyl methylcellulose inamandla okulwa ne-enzyme. Ngoko ke, ukuchasana kwe-enzyme egqwesileyo ye-hydroxypropyl methylcellulose, idibaniswe ne-dispersibility yayo efanelekileyo, i-thickening kunye ne-film-forming properties, isetyenziswe kwiingubo ze-emulsion yamanzi, njl., kwaye ngokuqhelekileyo ayifuni ukongeza i-preservatives. Nangona kunjalo, ukugcinwa kwexesha elide lesisombululo okanye ukungcoliseka okunokwenzeka okuvela ngaphandle, izilondolozo zinokongezwa njengento yokukhusela, kwaye ukhetho lunokumiselwa ngokweemfuno zokugqibela zesisombululo. I-Phenylmercuric acetate kunye ne-manganese fluorosilicate zizigcini ezisebenzayo, kodwa zonke zineToxicity, ingqwalasela kufuneka ihlawulwe ekusebenzeni. Ngokuqhelekileyo, i-1 ~ 5mg ye-phenylmercury acetate inokongezwa kwisisombululo kwilitha yedosi.
7. Ukusebenza kwe-hydroxypropyl methylcellulose membrane
Ukusebenza kwefilimu ye-hydroxypropyl methylcellulose i-Hydroxypropyl methylcellulose ineempawu ezintle kakhulu zokwenza ifilimu. Isisombululo saso samanzi okanye isisombululo se-solvent se-organic sifakwe kwipleyiti yeglasi, kwaye ayibabala kwaye ibonakale emva kokumisa. Kwaye ifilimu enzima. Inokumelana nokufuma okuhle kwaye ihlala yomelele kumaqondo obushushu aphezulu. Ukuba iplastiki ye-hygroscopic yongezwa, ukunyuswa kwayo kunye nokuguquguquka kwayo kunokwandiswa. Ngokumalunga nokuphucula ukuguquguquka, iiplastiki ezifana ne-glycerin kunye ne-sorbitol zizona zifanelekileyo. Ngokuqhelekileyo, i-concentration yesisombululo yi-2% ~ 3%, kwaye inani le-plasticizer yi-10% ~ 20% ye-cellulose ether. Ukuba umxholo we-plasticizer uphezulu kakhulu, i-colloidal dehydration shrinkage iya kwenzeka kumswakama ophezulu. Amandla okuqina kwefilimu eyongeziweyo nge-plasticizer inkulu kakhulu kunokuba ngaphandle kokongezwa, kwaye inyuka ngokunyuka kwexabiso elongezelelweyo, kunye ne-hygroscopicity yefilimu nayo iyanda ngokunyuka kwexabiso leplastiki.
Ixesha lokuposa: Dec-19-2022