IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa kakhulu kumashishini ahlukeneyo, kubandakanywa amayeza, ulwakhiwo, ukutya, kunye nezinto zokuthambisa. Iimpawu zayo ezizodwa zenza ukuba zixabiseke kwizicelo ezivela kwiinkqubo zokuhanjiswa kweziyobisi ukuya kwizinto zesamente. I-HPMC ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwizityalo, kwaye imveliso yayo ibandakanya ukuguqulwa kweekhemikhali ukuphumeza iimpawu ezithile.
I-HPMC yahlulwe yaba ngamabakala amaninzi, ngalinye lineempawu ezahlukeneyo kunye nokusetyenziswa. La mabanga ahluke kwiiparamitha ezifana nobunzima bemolekyuli, iqondo lokuthatha indawo, kunye ne-viscosity. Ukuwuqonda lo mahluko kubalulekile ekukhetheni ibakala elifanelekileyo kwisicelo esithile. Makhe sihlolisise kumabanga ahlukeneyo e-HPMC kunye nokusetyenziswa kwayo ngokwahlukeneyo.
Amabanga eViscosity:
I-HPMC ifumaneka kumabakala ahlukeneyo e-viscosity, ngokuqhelekileyo ukusuka kwi-viscosity ephantsi ukuya phezulu. I-viscosity yezisombululo ze-HPMC ixhomekeke kwizinto ezifana nobunzima bemolekyuli kunye neqondo lokuthatha indawo.
Amanqanaba asezantsi e-viscosity ahlala esetyenziswa kwizicelo ezifuna ukuchithwa ngokukhawuleza kunye namaqondo okushisa aphantsi kwe-gelation, njengakumachiza eepilisi ezikhutshwa ngokukhawuleza.
Amanqanaba aphezulu e-viscosity afanelekile kwizicelo ezifuna iijeli ezityebileyo okanye ukukhululwa ixesha elide, njengokuxutywa kokukhutshwa okuzinzileyo kumayeza.
Isidanga soTshintsho (DS):
I-DS ibhekisa kwiavareji yenani le-hydroxypropyl kunye ne-methoxy substituents ngeyunithi ye-anhydroglucose kwikhonkco leselulosi. Ichaphazela ukunyibilika, i-gelation, kunye neempawu zokwenza ifilimu ye-HPMC.
Amabanga anamaxabiso aphezulu e-DS abonisa ukunyibilika kwamanzi okuphuculweyo kunye nokwakheka kwefilim, ezenza zilungele usetyenziso olufana nokugqunywa kwefilimu kumayeza okanye njenge-arhente etyebisayo kwiimveliso zokutya.
Amabanga asezantsi e-DS anokubonelela ngozinzo olungcono lobushushu kunye nogcino lwamanzi, nto leyo ebenza ukuba bafaneleke usetyenziso kwizinto zokwakha ezifana nokunamathelisa iithayile okanye iimveliso ezisekwe kwigypsum.
Ubungakanani beNcam:
I-HPMC inokuveliswa kwiisayizi ezahlukeneyo zamasuntswana, eziphembelela iipropati ezinje ngokusasazwa, ukuqukuqela, kunye noburhabaxa ekubunjweni.
Amabakala obungakanani bamasuntswana amahle ahlala ekhethwa kwizicelo ezifuna ukuthungwa okugudileyo kunye nokusasazwa okufanayo, njengakwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu.
Amabanga aphantsi angathandwa kwizicelo apho ugcino lwamanzi oluphuculweyo okanye iimpawu zokunqunyanyiswa zifuneka, ezifana nodaka oluxubeneyo olomileyo okanye iikhompawundi ezidityanisiweyo.
Ukusulungeka nokuthotyelwa koMthetho:
Amabanga e-HPMC enzelwe izicelo zamayeza nokutya kufuneka ahlangabezane nemigangatho engqongqo yokucoceka kunye neemfuno zolawulo.
I-HPMC ye-Pharmaceutical-grade ivavanywa ngokucokisekileyo ukuqinisekisa ukuthotyelwa kwemigangatho ye-pharmacopeial malunga nokucoceka, ukungabikho kokungcola, kunye nokuhambelana nabanye abancedisi.
I-HPMC yodidi lokutya kufuneka ibambelele kwimimiselo ebekwe ngabasemagunyeni abafana ne-FDA okanye i-EFSA ukuqinisekisa ukhuseleko lokusetyenziswa kunye nokuthotyelwa kwemimiselo yokongezwa kokutya.
AmaBanga awodwa:
Amanye amabakala e-HPMC enzelwe usetyenziso oluthile, olufana neematriki ezikhutshwa ngokuzinzileyo, iinkqubo zokuhanjiswa kweziyobisi ezilawulwayo, okanye ukwakheka kwamehlo.
La mabanga akhethekileyo anokuthi aqhubeke eyongezelelweyo okanye uhlengahlengiso ukunika imisebenzi ethile, efana ne-mucoadhesion ephuculweyo, ukuphuculwa kwe-bioavailability, okanye iiprofayili zokukhululwa ezongeziweyo.
ukhetho lwebakala le-HPMC luxhomekeke kwiimfuno zesicelo esicetywayo, ngokuqwalasela izinto ezifana ne-viscosity, i-degree of substitution, ubungakanani bamasuntswana, ubunyulu, kunye nayiphi na imisebenzi ekhethekileyo efunekayo. Ukukhetha udidi olufanelekileyo kuqinisekisa ukusebenza ngokupheleleyo kunye neempawu ezinqwenelekayo kwimveliso yokugqibela, nokuba kukuqulunqwa kwamayeza, imathiriyeli yokwakha, imveliso yokutya, okanye ukwakhiwa kwezithambiso.
Ixesha lokuposa: May-24-2024