I-HPMC isebenzisa kwiipilisi zokwaleka

iipilisi zokwaleka isetyenziswa ngokubanzi kulungiselelo lwefomu eqinileyo, ngokutshoiipilisi zokwaleka izixhobo zingahlulwa zibe ngumguboiipilisi zokwaleka, ipelethiiipilisi zokwaleka, isuntswanaiipilisi zokwaleka, ithebhulethiiipilisi zokwaleka, i-capsuleiipilisi zokwaleka; Ngoku kaiipilisi zokwaleka izixhobo zohlulwe zibe iswekileiipilisi zokwaleka, ifilimu enesiqingathaiipilisi zokwaleka, ifilimuiipilisi zokwaleka (ngokusekwe kwiintlobo ngeentlobo zezixhobo zepolymer, kubandakanya i-entericiipilisi zokwaleka), izinto ezikhethekileyoiipilisi zokwaleka (ezifana ne-stearic acid, iparafini, i-polysaccharide); Ngoku kaiipilisi zokwaleka iteknoloji, inokwahlulwa ibe sisitshiziiipilisi zokwaleka, diphaiipilisi zokwaleka, uxinzelelo olomileyoiipilisi zokwaleka, i-electrostaticiipilisi zokwaleka kunye ne-laminatingiipilisi zokwaleka. Phakathi kwabo, fafazaiipilisi zokwaleka yeyona isetyenziswa kakhulu. Umgaqo wayo kukutshizaiipilisi zokwaleka ulwelo lube ngamathontsi enkungu agqume umphezulu wemathiriyeli (umgubo, amasuntswana, amacwecwe). Kwaye wome ngokukhawuleza ukwenza iiipilisi zokwaleka umaleko: ngokweiipilisi zokwaleka injongo yohlulwe ibe yi-soluble yamanziiipilisi zokwaleka, isisu siyanyibilikaiipilisi zokwaleka, ayinyibilikiyoiipilisi zokwaleka, ukukhululwa kancinciiipilisi zokwaleka, entericiipilisi zokwaleka.

Indima yeiipilisi zokwaleka iquka: (1) ukunganyameki, ukukhanya, ukwahlukaniswa komoya ukuze kwandiswe uzinzo lweziyobisi; (2) Gquma ivumba elibi, ukunciphisa ukuvuselela; (3) Phucula inkangeleko, kulula ukuyichonga; (4) Lawula indawo yokukhulula ichiza, njengakwijusi yesisu lula ukutshatyalaliswa ukuze ikhutshwe emathunjini: (5) lawula ukusasazeka kweziyobisi, isantya sokukhulula: (6) ukoyisa ukungahambelani, njl.iipilisi zokwaleka Isixhobo kufuneka sibe nezi mfuno zilandelayo: i-non-toxic, akukho inertia yekhemikhali, izinzile kubushushu, ukukhanya, amanzi, umoya, kwaye ayisebenziiipilisi zokwaleka iziyobisi; (2) inokunyibilikiswa ngokulinganayo kwindawo yokusasazwa okufanelekileyoiipilisi zokwaleka: (3) unokwenza umaleko oqhubekayo, oqinileyo, ogudileyo, uxhathise ukuqhekeka kwaye unokwahlula okulungileyo kwamanzi, ukwahlula ukufuma, ukuthuthumela, ukunyanzeliswa komoya;④I-solubility yayo kufuneka ihlangabezane neemfuno ze-fixed, ngamanye amaxesha akufuneki ukuba ichaphazeleke yi-PH, ngamanye amaxesha inokunyibilika kuphela kuluhlu oluthile lwe-PH. Uhlobo lwezinto eziphathekayo ezinophawu olungasentla ngexesha elifanayo alubonakali kakhulu, isizathu sivame ukusebenzisa umxubeiipilisi zokwaleka izinto ezininzi, ukuze sifunde omnye komnye.

Icwecweiipilisi zokwaleka yeyona isetyenziswa kakhulu, ihlala isebenzisa imbizaiipilisi zokwaleka kunye nombhobho ongcwatyweiipilisi zokwaleka (ukusebenza okuphezuluiipilisi zokwaleka umatshiniiipilisi zokwaleka), le yokugqibela ingcono kwifilimuiipilisi zokwaleka. Ibhedi ene-fluidizediipilisi zokwaleka ifaneleke ngakumbi kwizinto ezinobungakanani besuntswana elincinci njengeepellets kunye nomgubo. Xa kuthelekiswa neswekileiipilisi zokwaleka, ifilimuiipilisi zokwaleka ineengenelo ezininzi 1)Ukucutha ixesha kunye nokunciphisa iindleko zemathiriyeli; (2) akukho kwanda kubalulekileyo kobunzima: (3) akukho mfuneko yomaleko ongezantsi: (4) ukuqina, ukutyumza nokuxhathisa kokuqhekeka: (5) kunokuprintwa, kananjalo akuchaphazeli ukubhalwa kwetshiphu;(6) Inokukhusela ngokufanelekileyo imveliso kwimpembelelo yokukhanya, umoya kunye namanzi; (7) Akukho mpembelelo imbi ngexesha lokuqhekeka 8) ubuhle bemveliso 9)inika ithuba lokusebenzisa okungasebenzisi manziiipilisi zokwaleka; Iinkqubo kunye nemathiriyeli inokumiselwa ngokusemgangathweni. Ngoku uphuhliso lwemveliso entshaiipilisi zokwaleka Ukulungiselela ngokubanzi kwamkela ifilimuiipilisi zokwaleka, ifilimuiipilisi zokwaleka Ummiselo osisiseko wokuqamba ubandakanya iarhente yokwenza ifilim (iipilisi zokwaleka impahla), i-solvent, i-plasticizer, i-colorant, inokongeza i-arhente ebangela i-pore, i-insoluble filler, njl.iipilisi zokwaleka ummiselo ngundoqo kwimpumelelo yeiipilisi zokwaleka. Okwangoku, ifilimu enyibilikayo emanziniiipilisi zokwaleka izinto ezisetyenziswa ngokuqhelekileyo ziquka i-hydroxypropyl methyl cellulose (HPMC) kunye ne-hydroxypropyl cellulose (HPC). I-Polyethylene glycol (PEG), i-polyethylene pyrrolidone (PVP), izinto ezi-enteric-soluble ezibandakanya i-enteric-soluble acrylic resin, i-hydroxypropyl methyl cellulose phthalate (HPMCP). I-Cellulose acetate phthalate ester (CAP). I-Shellac, izinto ezinganyibilikiyo ziquka i-ethyl cellulose (EC), i-zein.

Ukutyhubela iminyaka, ifilimuiipilisi zokwaleka wenze inkqubela ephawulekayo. Umgangatho wemveliiipilisi zokwaleka ukusetyenziswa kwenkquboHPMC(i-hydroxypropyl methylcellulose) njengeyona polymer, esasetyenziswa kakhulu namhlanje. HPMC-esekelweiipilisi zokwaleka Iisistim zibonelela ngokwenziwa komsebenzi okwaneleyo, kodwa kusekho indawo yokuphucula. HPMCiipilisi zokwaleka Ifilimu ayinakubambelela kakuhle kwithebhulethi, ihlala indeiipilisi zokwaleka ixesha, okukhokelela kwimveliso ecothayo. Intshayelelo elandelayo yePVA esekelwe iipilisi zokwaleka Iisistim ziphucule ngakumbi ukusebenza, okukhokelela ekubeni ngconoiipilisi zokwaleka ukusebenza kunye nokusebenza ngokukhawuleza kwemveliso, oku kuthetha ukuba iziphene zingenakwenzeka ukuba zenzeke kwiipilisi.

Njengoko i-viscosity ye-HPMC isanda, amandla efilimu eyenziwe yi-HPMC iyanda ngokuhambelanayo, kwaye ekugqibeleni ifikelela kumandla aphezulu wefilimu ayisekho ukwanda kunye nokunyuka kwe-viscosity ye-HPMC.

Kwiiipilisi zokwaleka, ukwenzela ukufezekisa eyona nto isebenzayoiipilisi zokwaleka, rhoqo ukuphucula iiipilisi zokwaleka umxholo olwelo oluqinileyo, oya kukhokelela kwiiipilisi zokwaleka i-liquid viscosity iphezulu kakhulu, khetha i-viscosity ephantsi ye-HPMC inokusombulula ngempumelelo le ngxaki, kodwa ikhokelela ekubeni amandla efilimu achaphazelekayo. Ukulungelelanisa ezi ngxaki zimbini, ukuxuba iipolymers kuye kwaba sisixhobo esiqhelekileyo.

NjengeHPMCUmxholo we-E15 uyanda ngokuthe ngcembe, i-viscosity yomxube weHPMCe5 kwayeHPMCI-E15 nayo iyanda ngokuthe ngcembe.

Kwiswekileiipilisi zokwaleka, nathi siye sasuka kwi-art ukuya kwisayensi. Iimveliso eziqatywe iswekile ziyathandeka ngenxa yokuba zigudileyo, zimenyezelayo, nesiphelo esiswiti esigquma incasa ekrakra. Kodwa eyona mingeni kwiswekileiipilisi zokwaleka lala kwimveliso kunye nokuveliswa kwakhona. Iswekileiipilisi zokwaleka yinkqubo yezandla ethatha ixesha kwaye inokwahluka ukusuka kwibhetshi ukuya kwibhetshi ngokuxhomekeke kumntu owenzaiipilisi zokwaleka.