I-HPMC esetyenziswa kumathontsi esweni

I-Hydroxypropyl methylcellulose (HPMC) i-polymer esetyenziswa ngokubanzi kwishishini lamachiza, ngokukodwa ekuphuhliseni ukwakhiwa kwamachiza ophthalmic njengamaconsi esweni. Amathontsi emehlo asetyenziselwa ukunyanga iimeko ezahlukeneyo ezifana neliso elomileyo, iglaucoma, kunye ne-allergies. I-HPMC ingasetyenziswa kumathontsi esweni njenge-ejenti yokuphucula i-viscosity, i-agent ye-mucoadhesive, kunye ne-agent ekhuselayo. Kweli nqaku, siza kuphonononga ukusetyenziswa kwe-HPMC kumathontsi esweni ngokweenkcukacha.

I-arhente yokuphucula i-viscosity

Enye yeendima eziphambili ze-HPMC kumathontsi eso kukuphucula i-viscosity yabo. I-Viscosity yiparameter ebalulekileyo kwi-ophthalmic formulations njengoko inceda ekuqinisekiseni ukuba ukubunjwa kuhlala ku-ocular surface ngokwaneleyo ukubonelela ngeenzuzo zonyango. I-viscosity yezisombululo ze-HPMC ixhomekeke kubunzima bemolekyuli yepolymer kunye neqondo lokutshintshwa. Izisombululo ze-HPMC ezinobunzima obuphezulu bemolekyuli kunye nenqanaba lokuthatha indawo zine-viscosity ephezulu.

I-HPMC yeyona nto ibalaseleyo yokuphucula i-viscosity yamathontsi esweni njengoko ibonelela ngesiphumo esizinzileyo sokukhululwa ngenxa yeempawu zayo zokwenza ijeli. Ijeli eyenziwe yi-HPMC kumathontsi esweni yandisa ixesha lokudibana phakathi kwechiza kunye neliso, ngaloo ndlela iphucula ukusebenza kwechiza. Ngaphaya koko, izisombululo ze-HPMC azibonakalisi mfiliba, zizenza zibe lukhetho olufanelekileyo lwamathontsi eliso.

I-agent ye-Mucoadhesive

Enye indima ebalulekileyo ye-HPMC kwi-eye drops yimpawu zayo ze-mucoadhesive. I-HPMC inobudlelwane obuphezulu benwebu ze-mucus, kwaye ukusetyenziswa kwayo kumathontsi esweni kunokunceda ukwandisa ixesha lokuhlala lokuqulunqwa kumphezulu we-ocular. Oku kunenzuzo ngakumbi kunyango lwe-syndrome yamehlo eyomileyo, apho ukubonakaliswa kwexesha elide ekuqulunqweni kunokunceda ukunciphisa iimpawu zokomisa kunye nokungahambi kakuhle.

Iimpawu ze-mucoadhesive ze-HPMC zibalelwa kunxibelelwano lwe-hydrogen bonding kunye ne-mucin glycoprotein. I-Mucin glycoproteins yizona nxalenye eziphambili ze-ocular surface mucus layer, esebenza njengesithintelo sokukhusela. I-HPMC inokubambelela kumaleko we-mucus kwaye yandise ixesha loqhagamshelwano lokuqulunqwa kwi-ocular surface.

Ummeli okhuselayo

Ukongeza kwi-viscosity-ephuculweyo kunye neempawu ze-mucoadhesive, i-HPMC iphinda isetyenziswe njenge-agent ekhuselayo kumathontsi esweni. Umphezulu we-ocular usesichengeni sokonakala kwizinto zangaphandle ezifana nemitha ye-UV, ungcoliseko, kunye nomoya owomileyo. I-HPMC inokwenza ifilimu ekhuselayo phezu kwendawo ye-ocular enokunceda ukukhusela amehlo kule miba iyingozi.

Iimpawu zokukhusela ze-HPMC zibangelwa ukubunjwa kwe-gel-like layer on the surface ocular. Olu luhlu lusebenza njengesithintelo somzimba esinokunceda ukukhusela ukungena kwee-agent ezinobungozi kwiso. I-HPMC inokunceda kwakhona ukuthomalalisa umphezulu we-ocular kunye nokunciphisa iimpawu zokucaphuka kwamehlo.

Ukuqukumbela

Ukuqukumbela, i-HPMC yipolymer eguquguqukayo efumana ukusetyenziswa okubanzi ekuphuhliseni ukwakheka kwamachiza amehlo, ngakumbi amathontsi esweni. I-HPMC inokuphucula i-viscosity ye-eye drops, enokunceda ukwandisa ixesha labo lokuqhagamshelana nomphezulu we-ocular kunye nokuphucula ukusebenza kwabo. Iimpawu ze-HPMC ze-mucoadhesive zinokunceda ukwandisa ixesha lokuhlala lokuqulunqwa kumphezulu we-ocular, okwenza kube yindlela efanelekileyo yokunyanga isifo seso esomileyo. I-HPMC inokukhusela umphezulu we-ocular kwizinto ezinobungozi zangaphandle ngokwenza umaleko okhuselayo. Ukukhetha ngokucokisekileyo ibakala elifanelekileyo le-HPMC kunye nogxininiso lunokunceda ekuqinisekiseni ukusebenza kakuhle kunye nokuhambelana kwimixube eyehlayo.