I-HPMC kuMayeza

I-pharmaceutical excipient hydroxypropyl methyl cellulose (HPMC) i-non-ionic cellulose ether excipients, okwangoku iyona nto inkulu yokusetyenziswa kwasekhaya kunye nangaphandle kwe-excipients zonyango - a, njenge-excipient yonyango ineminyaka engaphezu kwe-30 yembali. Ayinavumba, ayinancasa, ayinatyhefu, iyanyibilika kumanzi abandayo, igelation emanzini ashushu, inqanaba elisezantsi le-viscosity HPMC ingasetyenziswa njengencamathelayo, iarhente yokuncamathela kunye nearhente yokunqunyanyiswa kwinqanaba le-viscosity ephezulu yeHPMC ingasetyenziselwa ukulungiselela isakhelo sezinto ezixubeneyo ezizinzileyo. iipilisi, ii-capsules ezikhutshwa ngokuzinzileyo, i-hydrophilic gel framework egcina i-blocker yokukhululwa kweepilisi, i-ejenti yokukhululwa elawulwayo kunye ne-agent ye-pore channel.

Izinto ezinceda amayeza zibhekiselele kwizinto ezincedisayo kunye nezincedisi ezisetyenziswa kwimveliso kunye nokukhutshwa kwamachiza. Into, ngaphandle kwesithako esisebenzayo, evavanyelwe ukhuseleko kwaye ibandakanywe kwimveliso yoxubo mayeza. Abaxhamli bamachiza banemisebenzi ebalulekileyo ye-solubilizing, ukuncedisa ukuchithwa, ukukhutshwa okucothayo kunye nokulawulwayo ngaphezu kokuqulunqa, ukuzalisa abathwali kunye nokuphucula ukuzinza, okunokuchaphazela umgangatho, ukhuseleko kunye nokusebenza kwamachiza.

IHydroxypropyl methyl cellulose HPMC yenye yezona zinto zinceda amayeza ekhaya naphesheya, esele isetyenziswe njengezinto ezincedisa amayeza iminyaka. Ayinavumba, ayinancasa kwaye ayinayo ityhefu, inyibilika emanzini abandayo kunye negelatin emanzini ashushu. I-HPMC njengendalo ye-hydrophilic polymer ye-pharmaceutical axiliary materials, ingasetyenziswa kuphela njengethebhulethi, igranule, i-adhesive yepilisi kunye ne-disintegrant, ifilimu yokugqoka ifilimu, ingasetyenziselwa njenge-agent ye-colloidal kunye ne-agent yokumiswa, ukukhululwa okucothayo kunye nokulawulwa kokukhululwa kwe-blocker, elawulwayo. i-arhente yokukhulula kunye ne-pore-making agent, kunye nomthwali we-dispersion eqinile.

I-HPMC njenge-binder kunye ne-arhente ehlukanisayo. I-HPMC njenge-binder inokunciphisa i-Angle yoqhagamshelwano yamachiza, ukuze iziyobisi zibe lula ukumanzisa, kwaye amanzi ayo anokwandisa amaxesha amaninzi, ngoko inokuphucula ngokubonakalayo ukuchithwa okanye ukukhululwa kweepilisi. I-HPMC ine-viscosity eyomeleleyo, kuba ukuthungwa kwezinto ezikrwada okanye ezilukhuni zinokuphucula i-viscosity yayo yamasuntswana, iphucule ukunyanzeliswa kwayo. HPMC viscosity ephantsi ingasetyenziswa njengesibophelelo kunye arhente disintegrating, viscosity eliphezulu kuphela njengesibophelelo, isixa iyahluka ngokomzekelo kunye neemfuno, isixa jikelele 2% -5%.

I-HPMC isetyenziswa njengesixhobo esilawulwayo sokukhululwa ukulungiselela ukulungiswa komlomo. I-HPMC sisixhobo sesakhelo se-hydrogel esiqhele ukusetyenziswa kumalungiselelo okhupho oluzinzileyo. I-HPMC enezinga eliphantsi le-viscosity (5~50mPa•s) ingasetyenziswa njenge-binder, i-adhesive-enhancing agent kunye ne-suspension aid, ngelixa i-HPMC enomgangatho ophezulu we-viscosity (4000 ~ 100000mPa • s) ingasetyenziselwa ukulungiselela isakhelo sezinto ezixubeneyo ezizinzileyo. iipilisi, i-capsules ekhutshwe ngokuqhubekayo, i-hydrophilic gel framework i-tablet ekhutshwa ngokuqhubekayo njenge-blocker. I-HPMC inokunyibilika kwi-gastric enteric fluid, ineenzuzo zokucinezeleka okulungileyo, ukuguquguquka okulungileyo, ukukwazi ukulayishwa kweziyobisi ezomeleleyo kunye neempawu zokukhutshwa kweziyobisi azichatshazelwa yi-pH, njl., yinto ebaluleke kakhulu ye-hydrophilic carrier kwi-system eqhubekayo yokulungiselela ukukhululwa, ngokuqhelekileyo. isetyenziswe njengesakhelo sejeli ye-hydrophilic kunye nemathiriyeli yokugquma yokulungiswa kokukhululwa okuzinzileyo, kwaye isetyenziswe kulungiselelo lokudada esiswini, ukukhululwa okuzinzileyo kwearhente yefilimu yeziyobisi.

I-HPMC njenge-arhente yokwenza ifilimu yokugquma. I-HPMC inokwakheka kwefilimu elungileyo, ibumba ifilimu ecacileyo, inzima, imveliso ayilula ukunamathela, ngakumbi ukufunxa ukufuma lula, iziyobisi ezingazinzanga, kunye nayo njengomaleko wokuzihlukanisa unokuphucula kakhulu uzinzo lweziyobisi, ukuthintela ukubola kwefilimu. Xa kuthelekiswa nokwakheka kwefilimu yegelatin, ifilimu ye-HPMC inokufaniswa kakuhle kunye nokuhanjiswa kokukhanya. I-HPMC ineentlobo ngeentlobo zenkcazo ye-viscosity, ukhetho olufanelekileyo, umgangatho wokugquma, inkangeleko ingcono kunokusebenzisa ezinye izinto, i-concentration yayo esetyenziswa ngokuqhelekileyo ye-2% -10%.

I-HPMC njenge-arhente yokunqunyanyiswa. Amalungiselelo olwelo olumisiweyo aqhele ukusetyenziswa kwiifomu zedosi yeklinikhi, eziziinkqubo zokusasazwa kwe-heterogeneous yamachiza aqinileyo anganyibilikiyo kumajelo osasazo olwelo. Uzinzo lwenkqubo lumisela umgangatho wokulungiswa kolwelo olumisiweyo. Isisombululo se-HPMC se-colloidal sinokunciphisa ukuxinana kwe-slid-liquid interface, ukunciphisa umphezulu wamandla okhululekileyo wamasuntswana aqinileyo, ukuze inkqubo yokusasazwa kwe-heterogeneous ithande ukuzinza, i-arhente egqwesileyo yokunqunyanyiswa. I-HPMC isetyenziswa njenge-thickener ye-eye drops, kunye nomxholo we-0.45% -1.0%.