HPMC kunyango lwezilwanyana

IHydroxypropyl methylcellulose (HPMC) yipolima esetyenziswa kakhulu kwishishini loxubo-mayeza, kwaye ikwasetyenziswa ekulungiseleleni amayeza ezilwanyana. I-HPMC yi-ether eselulosi enyibilikayo emanzini, engeyoyo-ionic ephuma kwiselulosi yendalo. Yipolymer ekhuselekileyo, ehambelanayo, kunye ne-biodegradable esetyenziselwa ukuphucula uzinzo, iimpawu ze-rheological, kunye ne-bioavailability yamayeza ezilwanyana. Kweli nqaku, siza kuxubusha iipropati kunye nokusetyenziswa kwe-HPMC kunyango lwezilwanyana.

Iipropati ze-HPMC

I-HPMC yi-semi-synthetic polymer ephuma kwi-cellulose. Inenani leempawu ezenza ukuba zilungele ukusetyenziswa kumayeza ezilwanyana. Ezi propati ziquka:

Ukunyibilika kwamanzi: HPMC kakhulu ukunyibilika emanzini, nto leyo ethetha ukuba lula ukunyibilika emanzini kunye nezinye izisombululo aqueous. Oku kwenza kube lula ukudibanisa kumayeza ezilwanyana.

Ukuziphatha kwePseudo-plastiki: I-HPMC ibonisa ukuziphatha kwe-pseudo-plastiki, oku kuthetha ukuba i-thixotropic kunye ne-shear-thinning. Le propati ivumela ukuba inciphise i-viscosity yokumiswa xa iphantsi koxinzelelo lwe-shear, okwenza kube lula ukulawula iyeza lezilwanyana.

Isakhono sokwenza ifilim: I-HPMC inamandla okwenza ifilim, nto leyo ethetha ukuba inokwenza umaleko okhuselayo kumphezulu wamasuntswana amayeza onyango lwezilwanyana, nto leyo enceda ukuwakhusela ekuthotyweni nasekuhlanganiseni.

Iimpawu ze-Mucoadhesive: I-HPMC ineempawu ze-mucoadhesive, nto leyo ethetha ukuba inokubambelela kwiindawo ze-mucosal emzimbeni. Le propati iluncedo kakhulu kwiinkqubo zokunikezelwa kweziyobisi ngomlomo nangeempumlo, njengoko ivumela ixesha elide loqhagamshelwano kunye nomphezulu we-mucosal kunye nokuphuculwa kokufunxa ichiza.

Ukusetyenziswa kweHPMC kwiVeterinary Medicine

I-HPMC isetyenziswa kwiindidi zamayeza ezilwanyana. Ezinye zezona zinto ziqhelekileyo zokusetyenziswa kwe-HPMC kunyango lwezilwanyana ziquka:

Uzinziso: I-HPMC isetyenziselwa ukuphucula uzinzo lwamayeza ezilwanyana. Inokunceda ukuthintela ukudityaniswa kwamasuntswana, i-flocculation, kunye ne-sedimentation, enokuphucula ubomi beshelufu yeyeza.

Ukuguqulwa kweRheological: I-HPMC ingasetyenziselwa ukuguqula iimpawu ze-rheological zamayeza ezilwanyana. Inokunceda ukunciphisa i-viscosity yeyeza, enokwenza kube lula ukulawula.

Ukukhululwa okulawulwayo: I-HPMC ingasetyenziselwa ukuphumeza ukukhululwa okulawulwayo kwamachiza kumayeza ezilwanyana. Isakhono sokwenza ifilimu ye-HPMC siyivumela ukuba yenze umaleko okhuselayo kumphezulu wamasuntswana echiza, ezinokucothisa ukukhutshwa kwechiza emzimbeni.

Ukomelezwa kweBioavailability: I-HPMC inokuphucula ukubakho kwamachiza kumayeza ezilwanyana. Iimpawu ze-mucoadhesive ze-HPMC zivumela ukuba zihambelane ne-mucosal surfaces emzimbeni, ezinokuthi ziphucule ukufunxwa kweziyobisi kunye ne-bioavailability.

Ukufihla incasa: I-HPMC ingasetyenziselwa ukugquma incasa engathandekiyo yamachiza kumayeza ezilwanyana. Oku kuluncedo kakhulu kwimixube yokwenziwa ngomlomo, njengoko kunokwenza iyeza libe nencasa ngakumbi kwaye kube lula ukulisebenzisa kwizilwanyana.

Imixube emixholweni: I-HPMC ikwasetyenziswa kwimixube esematheni kunyango lwezilwanyana. Ingasetyenziswa njenge-thickener, stabilizer, kunye ne-emulsifier kwi-creams, i-ointments, kunye nejeli. Ukuziphatha kwe-pseudo-plastiki ye-HPMC ivumela ukuba iphucule ukusasazeka kunye nokuhambelana kwe-topical formulation.

Amayeza atofwayo: I-HPMC isenokusetyenziswa kwimixube etofwayo kwiyeza lezilwanyana. Ingasetyenziselwa njenge-arhente yokumisa kunye ne-viscosity enhancer ukuphucula uzinzo kunye neempawu ze-rheological zenaliti.

Ukuqukumbela

Ukuqukumbela, i-HPMC yipolymer eguquguqukayo esetyenziswa kakhulu kwishishini lamayeza, kubandakanywa neyeza lezilwanyana. Ukunyibilika kwayo kwamanzi, ukuziphatha kwe-pseudo-plastiki, amandla okwenza ifilimu, iipropati ze-mucoadhesive, kunye nobuchule bokufihla incasa buyenza ibe yinto ebalulekileyo ekuqulunqweni kwamayeza ezilwanyana. HPMC unako ukuphucula uzinzo, iimpawu rheological, bioavailability, kunye nencasa amayeza ezilwanyana, ukwenza kube lula ukulawula kunye nokusebenza ngakumbi ekunyangeni izilwanyana.