I-HPMC yokunqunyanyiswa kwebakala leyeza

IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa kakhulu kwishishini lamayeza, ngakumbi kwiipropathi zayo ekulungiseleleni ukumiswa. I-HPMC yi-ether eselulosi enyibilikayo emanzini, engeyoyo-ionic ephuma kwiselulosi yendalo. Yipolymer ekhuselekileyo, ehambelana ne-biocompatible, kunye ne-biodegradable esetyenziselwa ukuphucula uzinzo, iimpawu ze-rheological, kunye ne-bioavailability yokunqunyanyiswa kweyeza. Kweli nqaku, siza kuxoxa ngeepropathi kunye nokusetyenziswa kwe-HPMC ekumisweni kwebakala leyeza.

Iipropati ze-HPMC

I-HPMC yi-semi-synthetic polymer ephuma kwi-cellulose. Inenani leempawu ezenza ukuba zilungele ukusetyenziswa ekumisweni kwamayeza. Ezi propati ziquka:

Ukunyibilika kwamanzi: HPMC kakhulu ukunyibilika emanzini, nto leyo ethetha ukuba lula ukunyibilika emanzini kunye nezinye izisombululo aqueous. Oku kwenza kube lula ukubandakanya ukunqunyanyiswa kwamayeza.

Ukuziphatha kwePseudo-plastiki: I-HPMC ibonisa ukuziphatha kwe-pseudo-plastiki, oku kuthetha ukuba i-thixotropic kunye ne-shear-thinning. Le propati ivumela ukuba inciphise i-viscosity yokumiswa xa iphantsi koxinzelelo lwe-shear, okwenza kube lula ukulawula ukumiswa.

Isakhono sokwenza ifilimu: I-HPMC inamandla okwenza ifilimu, oku kuthetha ukuba inokwenza umaleko okhuselayo kumphezulu wamasuntswana okunqunyanyiswa, okunceda ukukhusela ekuthotyweni nasekuhlanganiseni.

Iimpawu ze-Mucoadhesive: I-HPMC ineempawu ze-mucoadhesive, nto leyo ethetha ukuba inokubambelela kwiindawo ze-mucosal emzimbeni. Le propati iluncedo kakhulu kwiinkqubo zokunikezelwa kweziyobisi ngomlomo nangeempumlo, njengoko ivumela ixesha elide loqhagamshelwano kunye nomphezulu we-mucosal kunye nokuphuculwa kokufunxa ichiza.

Usetyenziso lwe-HPMC kuNxingo lweBanga loShishino

I-HPMC isetyenziswa kwiintlobo ngeentlobo zokunqunyanyiswa kwebakala loxubo-mayeza. Olunye lolona setyenziso luxhaphakileyo lwe-HPMC ekunqunyanyisweni konyango lubandakanya:

Uzinziso: I-HPMC isetyenziselwa ukuphucula uzinzo lokunqunyanyiswa kwamayeza. Inokukunceda ukukhusela i-particle aggregation, i-flocculation, kunye ne-sedimentation, enokuphucula ubomi beshelufu yokumiswa.

Ukuguqulwa kweRheological: I-HPMC ingasetyenziselwa ukuguqula iimpawu ze-rheological zokunqunyanyiswa kweyeza. Inokukunceda ukunciphisa i-viscosity yokumiswa, oku kunokwenza kube lula ukulawula ukumiswa.

Ukukhululwa okulawulwayo: I-HPMC ingasetyenziselwa ukuphumeza ukukhululwa okulawulwayo kwamachiza ukusuka ekumisweni kweyeza. Isakhono sokwenza ifilimu ye-HPMC siyivumela ukuba yenze umaleko okhuselayo kumphezulu wamasuntswana echiza, ezinokucothisa ukukhutshwa kwechiza emzimbeni.

Ukomelezwa kwe-Bioavailability: I-HPMC inokuphucula ukufumaneka kwe-bioavailability yamachiza ekunqunyanyisweni kweyeza. Iimpawu ze-mucoadhesive ze-HPMC zivumela ukuba zihambelane ne-mucosal surfaces emzimbeni, ezinokuthi ziphucule ukufunxwa kweziyobisi kunye ne-bioavailability.

Ukufihla incasa: I-HPMC ingasetyenziselwa ukufihla incasa engathandekiyo yamachiza ekunqunyanyisweni kwamayeza. Ifilimu yokwenza ifilimu ye-HPMC ivumela ukuba yenze umaleko okhuselayo ojikeleze amasuntswana echiza, anokuthintela ukukhutshwa kwechiza emlonyeni kunye nokufihla incasa yalo.

Ukuphuculwa kokuhambelana: I-HPMC inokuphucula ukuhambelana kwamachiza ekumisweni kwamachiza. Ubume bokunyibilika kwamanzi be-HPMC buvumela ukuba inyibilike emanzini kunye nezinye izisombululo ezinamanzi, ezinokuphucula ukuhambelana kwechiza kunye nezinye izinto ezincedisayo ekumisweni.

Ukuqukumbela

I-HPMC yipolymer esebenza ngeendlela ezininzi esetyenziswa ngokubanzi kushishino lwamayeza kwiipropati zayo ekulungiseleleni ukumiswa. Ukunyibilika kwayo emanzini, i-pseudo-plastiki indlela yokuziphatha, ifilimu yokwenza ifilimu, i-mucoadhesive properties, kunye ne-biocompatibility iyenza ibe yipolymer eluncedo ekuzinziseni ukumiswa kweyeza.