HPMC for Medicine

HPMCyezamayezaibe yenye yezixa zikhulu zeukhathalelo lwempilo kunyeabaxumi bamayeza ekhaya nakwamanye amazwe, kuba i-HPMC yamayeza ineengenelo ezingenazo ezinye ii-excipients.

1. Ukunyibilika kwamanzi

I-HPMC yamayeza inyibilika emanzini abandayo angaphantsi kwama-40 ℃ okanye ama-70% ethanol. Ayinyibiliki kumanzi ashushu angaphezu kwama-60 ℃, kodwa iyakwazi ukuxutywa.

2. Inertia yemichiza

I-HPMC yeyeza ye-ether ye-cellulose engekho i-ionic, isisombululo sayo asinayo i-ionic intlawulo kunye neetyuwa zetsimbi okanye i-ionic organic compounds, ngoko ke ekulungiseleleni inkqubo yokuvelisa, ezinye izinto ezincedisayo aziyi kusabela ngayo.

3. Ukuzinza

Izinzile kuzo zombini i-asidi kunye nesiseko, kwaye inokugcinwa kuluhlu lwe-PH 3 ~ 11 ixesha elide ngaphandle kotshintsho olucacileyo kwi-viscosity. Isisombululo samanzi se-HPMC sinokumelana nokungunda kwaye sinokugcina uzinzo oluhle lwe-viscosity kwindawo yokugcina ixesha elide. I-excipients zamachiza ezisebenzisa i-HPMC kwiyeza, ukuzinza komgangatho wayo kunokusetyenziswa kwezinto ezincedisayo zendabuko (ezifana ne-dextrin, istatshi, njl.) kungcono.

4. I-viscosity ehlengahlengiswayo

HPMC derivatives of viscosity ezahlukeneyo zinokudityaniswa ngokungqinelana nemilinganiselo eyahlukeneyo, viscosity yayo ingatshintsha ngokungqinelana nemithetho ethile, kwaye unobudlelwane obuhle linear, ngoko ke kunokukhethwa ngokweemfuno umlinganiselo. 2. I-5 inertia ye-metabolic HPMC ayifuntshwanga emzimbeni ayinayo i-metabolized, ayinikezeli ubushushu, ngoko ke i-excipients yokulungiselela amayeza ekhuselekileyo. .

5. Ukhuseleko

HPMCyezamayezangokuqhelekileyo ithathwa njengento engeyiyo ityhefu kwaye ingathukutheli.

IHydroxypropyl methyl cellulose (HPMC) yiiselulosiI-ether eveliswa ngokusabela kwekloromethane kunye nepropylene oxide enesiseko seselulosi. Ifiber emhlophe okanye ephantse ibe mhlophe okanye umgubo wegranular, ongenavumba. Isetyenziswe kumashishini amayeza iminyaka engaphezu kwe-40, kwaye yamkelwe kwi-USP19 edition kunye ne-Chinese Pharmacopoeia 1990 edition. Iphumelele iziphumo ezilungileyo kwizinto zokugqoka ifilimu kunye nezicelo zokubambelela.

Ibakala lamachizaHPMCI-hydroxypropyl methyl cellulose ineemfuno eziphezulu kwizinto eziluhlaza, iteknoloji yokuvelisa kunye nomgangatho wemveliso. Kwiminyaka yakutshanje, phantsi kweempembelelo zemigaqo-nkqubo engqongqo yokukhuselwa kwendalo, amanye amashishini amancinci ancedisa amayeza e-East China ade arhoxa kwintengiso, kunye nebakala loxubo-mayeza.HPMCi-hydroxypropyl methyl celluloseyezamayezaIshishini nalo liye lachatshazelwa, amandla okuvelisa amancinci arhoxile, kwaye ukugxininiswa kwamandla kuye kwaphuculwa.