HPMC for Film Coating

HPMC forUkugquma ifilimu bubuchule bokwenza ifilimu ebhityileyo yepolymer ngaphezulu kolungiselelo oluqinileyo. Umzekelo, umaleko wezinto ezizinzileyo zepolymer zitshizwa ngokulinganayo kumphezulu wephepha elingenanto ngokutshiza indlela yokwenza umaleko wefilimu yeplastiki engqindilili yemicrons ezininzi, ukuze kufikelelwe kwisiphumo esifunekayo. Ukuqulunqwa kolu luhlu lwefilimu ngaphandle kwethebhulethi kukuba ithebhulethi enye ibambelela kwizinto zokugqoka i-polymer emva kokudlula kwindawo yokutshiza, kwaye emva koko ifumana inxalenye elandelayo yezinto zokugubungela emva kokumisa. Emva kokunamathela ngokuphindaphindiweyo kunye nokumisa, ukugubungela kugqitywe de kube yonke indawo yokulungiswa ihlanganiswe ngokupheleleyo. Ukugquma ifilimu yifilimu eqhubekayo, ubukhulu becala phakathi kwe-8 ukuya kwi-100 microns, iqondo elithile lokuguquguquka kunye nokuguquguquka, ukubambelela ngokuqinileyo kumphezulu we-core.

Kwi-1954, u-Abbott wavelisa i-batch yokuqala yamaphepha efilimu afumanekayo ngokurhweba, ukususela ngoko, ngokuphuculwa okuqhubekayo kunye nokugqibelela kwezixhobo zokuvelisa kunye neteknoloji, izixhobo zefilimu ze-polymer zikhutshwe, ukwenzela ukuba iteknoloji yokugqoka ifilimu iphuhliswe ngokukhawuleza. Akunjalo kuphela iintlobo ezahlukeneyo, ubuninzi kunye nomgangatho wee-agent zokugqoka umbala ziye zanda ngokukhawuleza, kodwa kunye neentlobo, iifom kunye neempawu zobuchwepheshe bokugquma, izixhobo zokugubungela kunye nefilimu yokugqoka kunye nokufakwa kweepilisi ze-TCM ziphuhliswe kakhulu. Ke ngoko, ukusetyenziswa kwetekhnoloji yokugquma ifilimu kuye kwaba yimfuno kunye nophuhliso lwamashishini amayeza ukuphucula umgangatho wemveliso.

Ukusetyenziswa kwangethuba kwizinto zokubumba ifilimu yokugquma ifilimu, kusekho inani elikhulu leemveliso ezisebenzisa i-HPMCihydroxypropyl methylcellulosenjengemathiriyeli yeMembrane. KukuhlanjululwaHPMCicellulose evela kwilaphu yomqhaphu okanye intlama yeplanga, kunye nesisombululo sesodium hydroxide ukubonisa ukudumba kweselulosi yealkali, emva koko ngekloromethane kunye nonyango lwepropylene oxide ukufumana imethyl hydroxypropyl cellulose ether.HPMC, imveliso yokususa ukungcola emva kokumisa, ukutyumza, ukupakisha. Ngokubanzi, viscosity ephantsi HPMC isetyenziswa njengeifilimuizinto zokugquma, kunye ne-2% ~ 10% isisombululo sisetyenziswa njengesisombululo sokugquma. Ukungalungi kukuba i-viscosity inkulu kakhulu kwaye ukwandiswa kunamandla kakhulu.

Isizukulwana sesibini sezinto zokwenza ifilimu yi-polyvinyl alcohol (PVA). I-Polyvinyl alcohol yenziwa yi-alcoholsis ye-polyvinyl acetate. Iiyunithi eziphindayo zotywala beVinyl azinakusetyenziswa njengee-reactants kuba azihlangabezani nobuninzi kunye nokucoceka okufunekayo kwi-polymerization. Kwi-methanol, i-ethanol okanye i-ethanol kunye ne-methyl acetate isisombululo esixutywe kunye ne-alkali yensimbi okanye i-asidi ye-inorganic njenge-catalyst, i-hydrolysis ikhawuleza.

I-PVA isetyenziswa ngokubanzi kwi-coating yefilimu. Kuba ayinyibiliki emanzini kwiqondo lobushushu begumbi, ngokuqhelekileyo igqunywe malunga ne-20% yokusasazeka kwamanzi. Umphunga wamanzi kunye ne-oxygen permeability ye-PVA ingaphantsi kune-HPMC kunye ne-EC, ngoko ke amandla okuthintela umphunga wamanzi kunye ne-oksijini yomelele, enokukhusela ngcono i-chip core.

I-Plasticizer ibhekisela kwizinto ezinokunyusa iplastiki yezinto zokwenza ifilimu. Ezinye izinto zokwenza ifilimu zitshintsha iimpawu zabo zomzimba emva kokuba ubushushu buncitshisiwe, kwaye ukuhamba kwee-macromolecules zabo kuba kuncinci, okwenza i-coating ibe nzima kwaye i-brittle, ayinakho ukuguquguquka okufunekayo, kwaye ngoko kulula ukuphuka. I-Plasticizer yongezwa ukunciphisa ubushushu beglasi (Tg) kunye nokwandisa ukuguquguquka kokugquma. Iiplastiki ezisetyenziswa ngokuqhelekileyo ziipolima ezi-amorphous ezinobunzima obukhulu bemolekyuli kunye nobudlelwane obuqinileyo kunye nezixhobo zokwenza ifilim. I-plasticizer engenakunyibilika inceda ukunciphisa ukunyanzeliswa kwengubo, ngaloo ndlela ikhulise ukuzinza kwamalungiselelo.

Ngokuqhelekileyo kukholelwa ukuba indlela yeplastiki yeplastiki kukuba iimolekyuli zeplastiki zifakwe kwikhonkco le-polymer, elithintela intsebenziswano phakathi kweemolekyuli zepolymer ukuya kumlinganiselo omkhulu. Ukusebenzisana kulula xa ukusebenzisana kwe-polymer-plasticizer kunamandla kune-polymer-plasticizer interaction. Ngaloo ndlela, amathuba okuba amacandelo e-polymer ahambe ayanda.

Isizukulwana sesithathu sezinto zokwenza ifilimu yi-plasticizer ngendlela yekhemikhali efakwe kwifilimu yokwenza i-polymer

Umzekelo, ifilimu entsha yokwenza ifilimu i-Kollicoat® IR eyaziswa yi-BASF kukuba i-PEG ifakwe ngokwekhemikhali kwikhonkco elide le-PVA polymer ngaphandle kokongeza i-plasticizer, ngoko inokuphepha ukufuduka kwechibi emva kokugquma.