Hpmc Chemical | HPMC Excipients amayeza
Hydroxypropyl Methylcellulose(HPMC) yi-ether ye-cellulose efumana ukusetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanywa namayeza, njenge-excipient yamayeza. Nalu ujongo olusondeleyo kwi-HPMC njengekhemikhali kunye nendima yayo njengoncedo lwamayeza:
HPMC Chemical:
1. Ulwakhiwo lweMichiza:
- I-HPMC ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo.
- Idityaniswa ngokwazisa amaqela e-hydroxypropyl kunye ne-methyl kwi-cellulose backbone ngokusebenzisa inkqubo yekhemikhali eyaziwa ngokuba yi-etherification.
- Iqondo lokuthatha indawo (DS) libonisa umndilili wenani le-hydroxypropyl kunye namaqela e-methyl ancanyathiselwe kwiyunithi nganye ye-anhydroglucose kwikhonkco leselulosi.
2. Ukunyibilika kunye neViscosity:
- I-HPMC iyanyibilika emanzini kwaye yenza ijeli ecacileyo xa inyibilikiswa.
- Iimpawu zayo ze-viscosity zinokulawulwa, okwenza ukuba zilungele uluhlu olubanzi lwezicelo.
3. IiPropati zokwenziwa kwefilimu kunye nokutyebisa:
- I-HPMC ibonakalisa iipropati zokwenza ifilim, iyenza ixabiseke kwizinto zokwaleka kumayeza nakwamanye amashishini.
- Isebenza njenge-ejenti yokuqina kwiindlela ezahlukeneyo.
I-HPMC njengoMxumi wamayeza:
1. Ukwenziwa kweThebhulethi:
- Isibophelelo: I-HPMC isetyenziswa njengesibophelelo kuqulunqo lwethebhulethi, inceda ukubamba izithako zethebhulethi kunye.
- I-Disintegrant: Inokuthi isebenze njenge-disintegrant, iququzelele ukuchithwa kwamacwecwe kwindlela yokugaya.
2. Ukugqunywa kwefilimu:
- I-HPMC iqhele ukusetyenziselwa iipilisi zokugquma ifilimu kunye neepilisi kumayeza. Inika ukutyabeka okugudileyo kunye nokukhusela iyeza.
3. Iifomyula eziLawulwayo-zoKhupho:
- I-viscosity yayo kunye ne-film-forming properties yenza i-HPMC ilungele ukuqulunqwa kweziyobisi ezilawulwayo. Inceda ekulawuleni ukukhutshwa kwesithako esisebenzayo ngokuhamba kwexesha.
4. Ulwakhiwo lwamehlo:
- Kwizisombululo ze-ophthalmic, i-HPMC isetyenziselwa ukuphucula i-viscosity kunye nexesha lokugcinwa kwi-ocular surface.
5. Iinkqubo zokuhanjiswa kweziyobisi:
- I-HPMC iqeshwe kwiinkqubo ezahlukeneyo zokuhanjiswa kweziyobisi, inegalelo kuzinzo nokulawulwa kokukhululwa kwamachiza.
6. Ukhuseleko nokuThotyelwa kweMigaqo:
- I-HPMC esetyenziswa kumachiza ngokubanzi ithathwa njengekhuselekile (GRAS) kwaye ithobela imigangatho yolawulo yokusetyenziswa kwiimveliso zonyango.
7. Ukuhambelana:
- I-HPMC iyahambelana noluhlu olubanzi lwezithako ezisebenzayo zamachiza (APIs), okwenza kube yinto enokukhetha kuyo njenge-excipient yamayeza.
8. Ukonakala kwezinto eziphilayo:
- Njengezinye ii-ethers zeselulosi, i-HPMC ithathwa njenge-biodegradable kwaye inobuhlobo nokusingqongileyo.
Isishwankathelo, i-HPMC yikhemikhali eguquguqukayo eneempawu ezigqwesileyo kwizicelo zamayeza. Ukusetyenziswa kwayo njengoncedo lwamayeza kunegalelo ekwenziweni, ukuzinza, kunye nokusebenza kweemveliso ezahlukeneyo zamayeza, oko kuyenza ibe yinxalenye ebalulekileyo kwishishini loxubo-mayeza. Xa kuqwalaselwa i-HPMC kwizicelo zoxubo mayeza, kubalulekile ukukhetha ibakala elifanelekileyo ngokusekwe kwiimfuno ezithile zoqulunqo.
Ixesha lokuposa: Jan-14-2024