Gxininisa kwiCellulose ethers

Hpmc Chemical | HPMC Excipients amayeza

Hpmc Chemical | HPMC Excipients amayeza

Hydroxypropyl Methylcellulose(HPMC) yi-ether ye-cellulose efumana ukusetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanywa namayeza, njenge-excipient yamayeza. Nalu ujongo olusondeleyo kwi-HPMC njengekhemikhali kunye nendima yayo njengoncedo lwamayeza:

HPMC Chemical:

1. Ulwakhiwo lweMichiza:

  • I-HPMC ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo.
  • Idityaniswa ngokwazisa amaqela e-hydroxypropyl kunye ne-methyl kwi-cellulose backbone ngokusebenzisa inkqubo yekhemikhali eyaziwa ngokuba yi-etherification.
  • Iqondo lokuthatha indawo (DS) libonisa umndilili wenani le-hydroxypropyl kunye namaqela e-methyl ancanyathiselwe kwiyunithi nganye ye-anhydroglucose kwikhonkco leselulosi.

2. Ukunyibilika kunye neViscosity:

  • I-HPMC iyanyibilika emanzini kwaye yenza ijeli ecacileyo xa inyibilikiswa.
  • Iimpawu zayo ze-viscosity zinokulawulwa, okwenza ukuba zilungele uluhlu olubanzi lwezicelo.

3. IiPropati zokwenziwa kwefilimu kunye nokutyebisa:

  • I-HPMC ibonakalisa iipropati zokwenza ifilim, iyenza ixabiseke kwizinto zokwaleka kumayeza nakwamanye amashishini.
  • Isebenza njenge-ejenti yokuqina kwiindlela ezahlukeneyo.

I-HPMC njengoMxumi wamayeza:

1. Ukwenziwa kweThebhulethi:

  • Isibophelelo: I-HPMC isetyenziswa njengesibophelelo kuqulunqo lwethebhulethi, inceda ukubamba izithako zethebhulethi kunye.
  • I-Disintegrant: Inokuthi isebenze njenge-disintegrant, iququzelele ukuchithwa kwamacwecwe kwindlela yokugaya.

2. Ukugqunywa kwefilimu:

  • I-HPMC iqhele ukusetyenziselwa iipilisi zokugquma ifilimu kunye neepilisi kumayeza. Inika ukutyabeka okugudileyo kunye nokukhusela iyeza.

3. Iifomyula eziLawulwayo-zoKhupho:

  • I-viscosity yayo kunye ne-film-forming properties yenza i-HPMC ilungele ukuqulunqwa kweziyobisi ezilawulwayo. Inceda ekulawuleni ukukhutshwa kwesithako esisebenzayo ngokuhamba kwexesha.

4. Ulwakhiwo lwamehlo:

  • Kwizisombululo ze-ophthalmic, i-HPMC isetyenziselwa ukuphucula i-viscosity kunye nexesha lokugcinwa kwi-ocular surface.

5. Iinkqubo zokuhanjiswa kweziyobisi:

  • I-HPMC iqeshwe kwiinkqubo ezahlukeneyo zokuhanjiswa kweziyobisi, inegalelo kuzinzo nokulawulwa kokukhululwa kwamachiza.

6. Ukhuseleko nokuThotyelwa kweMigaqo:

  • I-HPMC esetyenziswa kumachiza ngokubanzi ithathwa njengekhuselekile (GRAS) kwaye ithobela imigangatho yolawulo yokusetyenziswa kwiimveliso zonyango.

7. Ukuhambelana:

  • I-HPMC iyahambelana noluhlu olubanzi lwezithako ezisebenzayo zamachiza (APIs), okwenza kube yinto enokukhetha kuyo njenge-excipient yamayeza.

8. Ukonakala kwezinto eziphilayo:

  • Njengezinye ii-ethers zeselulosi, i-HPMC ithathwa njenge-biodegradable kwaye inobuhlobo nokusingqongileyo.

Isishwankathelo, i-HPMC yikhemikhali eguquguqukayo eneempawu ezigqwesileyo kwizicelo zamayeza. Ukusetyenziswa kwayo njengoncedo lwamayeza kunegalelo ekwenziweni, ukuzinza, kunye nokusebenza kweemveliso ezahlukeneyo zamayeza, oko kuyenza ibe yinxalenye ebalulekileyo kwishishini loxubo-mayeza. Xa kuqwalaselwa i-HPMC kwizicelo zoxubo mayeza, kubalulekile ukukhetha ibakala elifanelekileyo ngokusekwe kwiimfuno ezithile zoqulunqo.


Ixesha lokuposa: Jan-14-2024
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