1. Intshayelelo
Kwishishini lamachiza, ukulawula ukukhutshwa kwechiza kunye nokuzinza kwechiza ngumsebenzi obalulekileyo ekwenziweni kwamachiza. I-Hydroxypropyl Methylcellulose (HPMC) i-cellulose ether yimathiriyeli ye-polymer esebenzayo esetyenziswa ngokubanzi ekuqulunqweni kweziyobisi. I-HPMC iye yaba licandelo eliphambili leefom ezininzi zedosi eqinileyo kunye ne-semisolid ngenxa yeempawu zayo ezizodwa kunye neekhemikhali, ngakumbi amandla okugcina amanzi alungileyo.
2. Ubume kunye neePropati ze-HPMC
I-HPMC yikhompawundi yepolymer enyibilikayo emanzini efunyenwe nge-methylating kunye ne-hydroxypropylating cellulose. Isakhiwo sayo se-molecular siqukethe i-cellulose skeleton kunye ne-methoxy esasazwa ngokungahleliwe (-OCH₃) kunye ne-hydroxypropoxy (-OCH₂CHOHCH₃) i-substituents ezinika i-HPMC ibhalansi ekhethekileyo ye-hydrophilicity kunye ne-hydrophobicity, eyenza ukuba yenze isisombululo se-viscous okanye i-gel emanzini. Le propati ibaluleke kakhulu ekuqulunqweni kwamachiza kuba inceda ukulawula izinga lokukhululwa kunye nokuzinza kwechiza.
3. Indlela yokugcina amanzi ye-HPMC
Ugcino lwamanzi lwe-HPMC lubangelwa ikakhulu kukukwazi ukufunxa amanzi, ukudumba nokwenza iijeli. Xa i-HPMC ikwimekobume enamanzi, i-hydroxyl kunye namaqela e-ethoxy kwiimolekyuli zayo zisebenzisana neemolekyuli zamanzi ngeebhondi ze-hydrogen, ezivumela ukuba zifunxe isixa esikhulu samanzi. Le nkqubo ibangela ukuba i-HPMC idumbe kwaye yenze ijeli ye-viscoelastic kakhulu. Le gel inokwenza i-barrier layer ekuqulunqweni kweziyobisi, ngaloo ndlela ilawula ukuchithwa kunye nokukhululwa kweyeza.
Ukufunxwa kwamanzi kunye nokudumba: Emva kokuba iimolekyuli ze-HPMC zifunxa amanzi emanzini, umthamo wazo uyanda kwaye wenze isisombululo esiphezulu se-viscosity okanye ijeli. Le nkqubo ixhomekeke ekudibaneni kwehydrogen phakathi kwamatyathanga emolekyuli kunye ne-hydrophilicity ye-cellulose skeleton. Oku kudumba kwenza i-HPMC ibambe kwaye igcine amanzi, ngaloo ndlela idlala indima ekugcineni amanzi ekuxutyweni kweziyobisi.
Ukubunjwa kweGel: I-HPMC yenza ijeli emva kokunyibilika emanzini. Ubume bejeli buxhomekeke kwizinto ezifana nobunzima bemolekyuli, iqondo lokutshintshwa kunye nobushushu besisombululo se-HPMC. Ijeli inokwenza umaleko okhuselayo kumphezulu weyeza ukuthintela ukulahleka okukhulu kwamanzi, ngakumbi xa indawo yangaphandle yomile. Olu luhlu lwejeli lunokulibazisa ukuchithwa kwechiza, ngaloo ndlela lufezekisa umphumo wokukhululwa okuqhubekayo.
4. Ukusetyenziswa kwe-HPMC ekuxutyweni kweziyobisi
I-HPMC isetyenziswa ngokubanzi kwiifom ezahlukeneyo zedosi yeziyobisi, kubandakanywa iipilisi, iijeli, iikhrimu, amalungiselelo amehlo kunye namalungiselelo okukhululwa okuqhubekayo.
Iipilisi: Kwimiqulu yethebhulethi, i-HPMC idla ngokusetyenziswa njenge-binder okanye i-disintegrant, kwaye umthamo wayo wokugcina amanzi unokuphucula ukunyibilika kunye nokufumaneka kwe-bioavailability yamacwecwe. Kwangaxeshanye, i-HPMC inokulawula izinga lokukhululwa kweziyobisi ngokwenza umaleko wejeli, ukuze ichiza likhutshwe kancinci kwindlela yesisu, ngaloo ndlela landa ixesha lesenzo sechiza.
Iigels kunye ne-creams: Kumalungiselelo asemgangathweni, ukugcinwa kwamanzi kwe-HPMC kunceda ekuphuculeni isiphumo sokuthambisa samalungiselelo, okwenza ukufunxwa kwezithako ezisebenzayo eluswini kuzinzile kwaye zihlale. HPMC nako ukwandisa ukusasazeka kunye nentuthuzelo imveliso.
Amalungiselelo e-Ophthalmic: Kumalungiselelo e-ophthalmic, ukugcinwa kwamanzi kunye neepropati zokwenza ifilimu ye-HPMC inceda ukunyusa ixesha lokuhlala kwechiza kwindawo ye-ocular, ngaloo ndlela kwandisa i-bioavailability kunye nesiphumo sonyango lwechiza.
Amalungiselelo okukhutshwa okuzinzileyo: I-HPMC isetyenziswe njengesixhobo se-matrix kumalungiselelo okukhululwa okuqhubekayo, kwaye inokulawula ukukhutshwa kwamachiza ngokulungelelanisa ukubunjwa kunye nokuziphatha kokuchithwa kwe-gel layer. Ukugcinwa kwamanzi kwe-HPMC kwenza amalungiselelo okukhululwa okuqhubekayo ukugcina izinga lokukhululwa elizinzile ixesha elide, ukuphucula ukusebenza kweyeza.
5. Izinto eziluncedo ze-HPMC
Njengearhente yokugcina amanzi kuqulunqo lwamachiza, i-HPMC inezi zibonelelo zilandelayo:
Ukugcinwa kwamanzi aphezulu: I-HPMC inokufunxa kwaye igcine isixa esikhulu samanzi, yenze umaleko wejeli ozinzileyo, kwaye ilibazise ukuchithwa nokukhululwa kweziyobisi.
Biocompatibility Good: I-HPMC ine-biocompatibility efanelekileyo, ayibangeli impendulo yomzimba okanye ityhefu, kwaye ifanelekile kwimixube eyahlukeneyo yamachiza.
Ukuzinza: I-HPMC inokugcina iipropati ezizinzileyo zomzimba kunye neekhemikhali phantsi kweemeko ezahlukeneyo ze-pH kunye nobushushu, ukuqinisekisa ukuzinza kwexesha elide lokuqulunqwa kweziyobisi.
Ukulungelelaniswa: Ngokutshintsha ubunzima bemolekyuli kunye neqondo lokutshintshwa kwe-HPMC, ukugcinwa kwamanzi kunye nokukwazi ukwenza i-gel kunokulungelelaniswa ukuhlangabezana neemfuno zemixube eyahlukeneyo yamachiza.
I-HPMC cellulose ether idlala indima ebalulekileyo njenge-arhente yokugcina amanzi ekuqulunqweni kwamachiza. Isakhiwo sayo esiyingqayizivele kunye neempawu zenza ukuba zikwazi ukufunxa ngokufanelekileyo kwaye zigcine amanzi, zenze i-gel layer, kwaye ngaloo ndlela ilawule ukukhululwa kunye nokuzinza kweziyobisi. Ukusetyenziswa kwezinto ezininzi kwe-HPMC kunye nogcino lwamanzi olugqwesileyo kukwenza ukuba ibe yinto eyimfuneko ekuxutyweni kwamachiza ale mihla, inika inkxaso eyomeleleyo kuphuhliso nokusetyenziswa kwamachiza. Kwixesha elizayo, ngophuhliso oluqhubekayo lweteknoloji yonyango, amathuba okusetyenziswa kwe-HPMC ekuqulunqweni kwamachiza aya kuba banzi.
Ixesha lokuposa: Jul-08-2024