Ukulungiselela i-hydroxypropyl methylcellulose (HPMC) izisombululo zokugquma kubandakanya amanyathelo amaninzi kwaye kufuna ingqalelo enonophelo kwiinkcukacha. I-HPMC iqhele ukusetyenziswa njengesixhobo sokugquma ifilimu kumashishini oxubo mayeza kunye nokutya. Izisombululo zokugqoka zisetyenziselwa iipilisi okanye iigranules ukubonelela ngoluhlu olukhuselayo, ukuphucula ukubonakala, kunye nokuququzelela ukugwinya.
1. Intshayelelo yokwaleka kweHPMC:
IHydroxypropylmethylcellulose (HPMC) yi-cellulose-based polymer ephuma kwimicu yezityalo. Ngenxa yeempawu zayo zokwenza ifilimu kunye nokuqina, isetyenziswa ngokubanzi kwiingubo zefilimu kumashishini amayeza kunye nokutya.
2. Imathiriyeli efunekayo:
I-Hydroxypropyl methylcellulose powder
Hlambulula amanzi
Izikhongozeli zePlastiki okanye zensimbi engenasici
Izixhobo ezishukumisayo (umz. imagnethi yokushukuma)
Izixhobo zokulinganisa (izikali, iisilinda zokulinganisa)
imitha ye-pH
Iplastiki okanye i-pan yokugquma intsimbi
I-oveni yomoya oshushu
3.inkqubo:
Yenza umlinganiselo weHPMC:
Ukulinganisa ngokuchanekileyo inani elifunekayo lepowder ye-HPMC esekelwe kuyilo olufunwayo lwengubo. Ugxininiso ludla ngokuba phakathi kwe-2% kunye ne-10%.
Lungisa amanzi acocekileyo:
Sebenzisa amanzi ahlanjululweyo ukuqinisekisa ukuba ayinakungcoliswa okunokuchaphazela umgangatho wengubo. Amanzi kufuneka abe kwiqondo lobushushu begumbi.
Ukusasazwa kwe-HPMC:
Yongeza kancinane umgubo we-HPMC olinganisiweyo kumanzi ahlambulukileyo ngelixa uvuselela ngokuqhubekayo. Oku kuthintela ukuba i-clumps yenze.
Gxuma:
Gxuma umxube usebenzisa i-stirrer magnetic okanye esinye isixhobo esifanelekileyo esishukumisayo de umgubo we-HPMC uhlakazwe ngokupheleleyo emanzini.
Uhlengahlengiso lwe-pH:
Ukulinganisa i-pH yesisombululo se-HPMC usebenzisa imitha ye-pH. Ukuba kuyimfuneko, i-pH inokulungelelaniswa ngokongeza inani elincinci le-asidi okanye isiseko ngokufanelekileyo. I-pH efanelekileyo yokugquma ifilimu idla ngokuba kuluhlu lwe-5.0 ukuya kwi-7.0.
Ukufuma kunye nokuguga:
Isisombululo se-HPMC sivumelekile ukuba sifakwe emanzini kunye nobudala bexesha elithile. Oku kwandisa iipropati zokwenza ifilimu. Ixesha lokuguga linokwahluka kodwa ngokuqhelekileyo likuluhlu lweeyure ezi-2 ukuya kwezingama-24.
isihluzi:
Hlunga isisombululo se-HPMC sokususa nawaphi na amasuntswana anganyibilikiyo okanye ukungcola. Eli nyathelo liyimfuneko ukuze ufumane isisombululo esigudileyo, esicacileyo sokugquma.
Uhlengahlengiso lweViscosity:
Ukulinganisa i-viscosity yesisombululo kwaye uyilungelelanise kwinqanaba elifunekayo. I-Viscosity ichaphazela ukufana kunye nobukhulu bengubo.
Ukuhambelana kovavanyo:
Ukuvavanya ukuhambelana kwesisombululo sokugubungela kunye ne-substrate (iipilisi okanye i-granules) ukuqinisekisa ukunamathela ngokufanelekileyo kunye nokwakheka kwefilimu.
Inkqubo yokwaleka:
Sebenzisa i-pan yokugqoka efanelekileyo kwaye usebenzise umatshini wokugquma ukusebenzisa isisombululo se-HPMC sokugubungela kwiipilisi okanye iigranules. Lungisa isantya sembiza kunye neqondo lobushushu lomoya ukuze ufumane ukutyabeka kakuhle.
ukomisa:
Iipilisi okanye i-granules ezigqunyiweyo zomiswa kwi-oven yomoya oshushu olawulwa ngubushushu kuze kube yilapho ubukhulu obufunwayo bufezekiswa.
QC:
Ukuqhuba uvavanyo lokulawula umgangatho weemveliso ezigqunyiweyo kubandakanywa inkangeleko, ubukhulu kunye neempawu zokutshatyalaliswa.
4. Ekuqukumbeleni:
Ukulungiswa kwezisombululo zokugquma kwe-HPMC kubandakanya uthotho lwamanyathelo achanekileyo okuqinisekisa umgangatho kunye nokusebenza kakuhle kwengubo. Ukuthotyelwa kweenkqubo ezimiselweyo kunye namanyathelo okulawula umgangatho kubalulekile ekufumaneni iziphumo ezihambelanayo nezithembekileyo kumashishini amayeza kunye nokutya. Ngalo lonke ixesha ulandela i-Good Manufacturing Practices (GMP) kunye nezikhokelo ezihambelanayo ngexesha lenkqubo yokugubungela.
Ixesha lokuposa: Jan-18-2024