Ukuphucula umlinganiselo wokuqulunqwa kwe-HPMC kwi-tablet yokugquma yinkqubo enzima ebandakanya ukuqonda iimpawu zomzimba kunye neekhemikhali ze-HPMC kunye nendlela yokufezekisa umsebenzi ofunekayo wokugquma ngokulungelelanisa ukuqulunqwa.
Khetha inkcazo ye-viscosity efanelekileyo ye-HPMC: I-HPMC ineentlobo ezahlukeneyo zenkcazo ye-viscosity. I-HPMC ene-viscosities eyahlukeneyo iya kuchaphazela umxholo oqinileyo kunye neepropati zokwenza ifilimu yokugqoka. I-viscosity ephantsi HPMC inceda ukunyusa umxholo wezinto eziqinileyo, kodwa kunokufuneka ukuba zidityaniswe namanye amabanga e-HPMC ukuthatha ithuba leempawu zabo ezahlukeneyo zomzimba.
Sebenzisa indibaniselwano yenkcazelo ezininzi ze-HPMC: Kwiifomula eziphuculweyo, ii-HPMC ezininzi zeenkcukacha ezahlukeneyo zidla ngokusetyenziswa ngaxeshanye ukusebenzisa ngokubanzi iipropati zazo ezahlukeneyo zomzimba. Olu kudibanisa luphucula ukusebenza kakuhle kokwambathisa kunye nomgangatho.
Ukongeza i-plasticizers: Iiplastiki ezifana ne-polyethylene glycol (PEG), i-triethyl citrate, njl.
Qwalasela ukugxininiswa kwesisombululo sokugquma: Umxholo oqinileyo wesisombululo sokugquma unempembelelo enkulu ekusebenzeni kakuhle kwengubo. Ukugquma ulwelo olunomxholo ophezulu oqinileyo kunokunciphisa ixesha lokugquma kunye nokuphucula ukusebenza kakuhle kwemveliso. Ngokomzekelo, xa usebenzisa i-Kollicoat® IR-based based materials, i-coating formulation concentrations ingaba phezulu njenge-30%.
Yandisa iiparamitha zenkqubo yokugquma: Iiparamitha zenkqubo yokugquma, ezinje ngesantya sokutshiza, ubushushu bomoya wokungena, ubushushu bembiza, uxinzelelo lwe-atomization, kunye nesantya sembiza, ziya kuchaphazela umgangatho wokugquma kunye nokufana. Ngokulungelelanisa ezi parameters, iziphumo ezifanelekileyo zokugquma zinokufumaneka.
Ukusetyenziswa kobunzima obutsha be-molecular HPMC: I-HPMC entsha ye-molecular weight (efana ne-hypromellose 2906, i-VLV hypromellose) inokuphucula inkqubo yokugubungela ithebhulethi kunye nokunciphisa iindleko. Ngokudibanisa ne-HPMC eqhelekileyo, iipropathi zokwaleka ezilungeleleneyo zinokufumaneka kwiingubo eziphakamileyo eziphezulu, akukho miba yokuncamathela phantsi kweemeko zokwaleka ezithambileyo, kunye nokuqina kwefilimu yethebhulethi.
Cinga ukuzinza kwezinto zokugquma: I-HPMCP iyipolymer ezinzile kakhulu ukuzinza kwayo kugcinwa phantsi kweemeko zomswakama ophezulu, obaluleke kakhulu ekuqinisekiseni umgangatho weepilisi ezifakwe ngexesha lokugcinwa.
Lungisa indlela yokulungiswa kwesisombululo sokugubungela: Kwimeko yokulungiswa ngokuthe ngqo kwi-solvent edibeneyo, ngokuthe ngcembe yongeza i-HPMCP powder kwi-solvent edibeneyo ukuze ugweme ukubunjwa kwe-agglomerates. Ezinye izithako kwisisombululo sokugquma ezifana ne-plasticizers, i-pigments kunye ne-talc nazo kufuneka zongezwe njengoko kufuneka.
Qwalasela iipropathi zechiza: Ukunyibilika kunye nokuzinza kwechiza kuya kuba nefuthe ekukhetheni ukwakheka kwengubo. Ngokomzekelo, kumachiza e-photosensitive, ii-opacifiers zisenokufuneka ukukhusela ichiza ekuwohlokeni.
Ukuqhuba uvavanyo lwe-in vitro kunye nezifundo zokuzinza: Ngovavanyo lwe-in vitro dissolution kunye nezifundo zokuzinza, ukusebenza kweepilisi ezifakwe kwi-coated kunokuvavanywa ukuqinisekisa ukusebenza kunye nokuzinza kwefomula yokugqoka kwizicelo eziphathekayo.
Ngokuqwalasela ngokubanzi le miba ingasentla kunye nokulungelelanisa ngokwemiqathango ethile yokuvelisa kunye neempawu zamachiza, umlinganiselo wefomyula ye-HPMC kwi-tablet coating inokuphuculwa ukuze kuphunyezwe iziphumo ezisebenzayo, ezifanayo kunye nezizinzileyo.
Ixesha lokuposa: Oct-29-2024