I-Hydroxypropyl Methylcellulose (HPMC) yi-ether ye-cellulose eguqulwayo esetyenziswa ngokubanzi kumalungiselelo amayeza, izongezo zokutya, izinto zokwakha, izimonyo kunye nezinye iinkalo. I-HPMC inokuqina, ukwenza ifilimu, ukunamathela kunye nezinye iimpawu. Ubudlelwane phakathi kwe-viscosity kunye nokugxilwa kwesisombululo saso samanzi kubaluleke kakhulu kwizicelo ezahlukeneyo.
Iimpawu zeViscosity zesisombululo se-aqueous HPMC
Iimpawu eziphambili
I-HPMC yenza isisombululo se-viscous esicacileyo okanye esiguquguqukayo emva kokunyibilika emanzini. I-viscosity yayo ayichatshazelwa kuphela kukugxininiswa kwe-HPMC, kodwa kunye nezinto ezifana nobunzima be-molecular, uhlobo olubambeleyo kunye nobushushu besisombululo.
Ubunzima bemolekyuli: Ubukhulu ubunzima bemolekyuli ye-HPMC, kokukhona isisombululo se-viscosity. Oku kungenxa yokuba ii-macromolecules zenza ulwakhiwo oluntsonkothileyo olubambeneyo kwisisombululo, oko kwandisa ukungqubana phakathi kweemolekyuli.
Uhlobo lwe-substituent: Umlinganiselo we-methoxy kunye ne-hydroxypropoxy substituents ichaphazela ukunyibilika kunye ne-viscosity ye-HPMC. Ngokuqhelekileyo, xa umxholo we-methoxy uphezulu, i-solubility ye-HPMC ingcono kwaye i-viscosity yesisombululo nayo iphezulu.
Ubudlelwane phakathi koxinzelelo kunye ne-viscosity
Inqanaba lokunciphisa isisombululo:
Xa i-concentration ye-HPMC iphantsi, intsebenziswano phakathi kweeamolekyu ibuthathaka kwaye isisombululo sibonisa iimpawu ze-Newtonian fluid, oko kukuthi, i-viscosity ixhomekeke kwizinga lokucheba.
Ngeli nqanaba, i-viscosity yesisombululo iyanda ngokuhambelana nokunyuka koxinzelelo. Obu budlelwane bomgca bunokubonakaliswa nge-equation ye-viscosity elula:
| Ugxininiso (%) | Viscosity (mPa·s) |
| 0.5 | 100 |
| 1.0 | 300 |
| 2.0 | 1000 |
| 5.0 | 5000 |
| 10.0 | 20000 |
Inokubonwa kwidatha yokuba i-viscosity ye-HPMC isisombululo samanzi sanda ngokukhawuleza ngokunyuka koxinzelelo. Oku kukhula kuya kubonakala kwigrafu njengegophe elinyukayo, ngakumbi kwiindawo zokugxila okuphezulu.
Imiba enempembelelo
Isiphumo sobushushu
Ubushushu bunempembelelo ebalulekileyo kwi-viscosity yesisombululo se-HPMC. Ngokuqhelekileyo, ukunyuka kweqondo lokushisa kunciphisa i-viscosity yesisombululo. Oku kungenxa yokuba ukunyuka kwamaqondo obushushu kubangela ukunyuka kwentshukumo yeemolekyuli kwaye kwenza buthathaka intsebenziswano phakathi kwamatyathanga eemolekyuli, ngaloo ndlela kunciphisa i-viscosity.
Isiphumo somlinganiselo wokucheba
Ukufumana izisombululo eziphezulu ze-HPMC, i-viscosity iphinda ichaphazeleke ngezinga lokucheba. Kwizinga eliphezulu lokucheba, ukuqhelaniswa kwamaketanga eemolekyuli kuya kuhambelana ngakumbi kwaye ukungqubuzana kwangaphakathi kuncitshisiwe, okubangelwa yi-viscosity ephantsi ebonakalayo yesisombululo. Le nto ibizwa ngokuba kukucheba.
Usetyenziso
Kumalungiselelo amayeza, i-HPMC iqhele ukusetyenziswa kwiingubo zeepilisi, iifom zedosi yokukhululwa okuqhubekayo, kunye ne-thickeners. Ukuqonda ukuba i-viscosity ye-HPMC izisombululo zamanzi zitshintsha njani ngoxinaniso kubalulekile ekuyileni imixube yamachiza efanelekileyo. Ngokomzekelo, kwi-tablet yokugquma, ugxininiso olufanelekileyo lwe-HPMC lunokuqinisekisa ukuba ulwelo lokugquma lune-viscosity eyaneleyo yokugubungela umphezulu wethebhulethi, ngelixa ungekho phezulu kakhulu ukuba kube nzima ukuphatha.
Kwishishini lokutya, i-HPMC isetyenziswa njenge-thickener kunye ne-stabilizer. Ukuqonda ubudlelwane phakathi koxinaniso kunye ne-viscosity kunokunceda ukumisela ugxininiso olufanelekileyo ukuqinisekisa incasa kunye nokuthungwa kokutya.
I-viscosity yesisombululo se-aqueous ye-HPMC inobudlelwane obubalulekileyo kunye noxinzelelo. Ibonisa ukunyuka komgca kwinqanaba lesisombululo se-dilute kunye nokunyuka okubonakalayo ekugxininiseni okuphezulu. Olu phawu lwe-viscosity lubalulekile kwiinkqubo ezahlukeneyo zemizi-mveliso, kwaye ukuqonda kunye nokulawula utshintsho lwe-viscosity ye-HPMC kubaluleke kakhulu ekuphuculeni inkqubo kunye nokuphuculwa komgangatho wemveliso.
Ixesha lokuposa: Jul-08-2024